Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Rilei Yu"'
Autor:
Nannan Song, Xian Guan, Siqi Zhang, Yanqing Wang, Xuekai Wang, Zhongxia Lu, Daochen Chong, Jennifer Yiyang Wang, Rilei Yu, Wengong Yu, Tao Jiang, Yuchao Gu
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-14 (2023)
Abstract Pancreatic cancer is a highly aggressive cancer, and is primarily treated with gemcitabine, with increasing resistance. SIRT6 as a member of sirtuin family plays important roles in lifespan and diverse diseases, such as cancer, diabetes, inf
Externí odkaz:
https://doaj.org/article/938516f9a4984d6f9d828e81d45d9846
Autor:
Xin Jin, Tingting Qiu, Li Li, Rilei Yu, Xiguang Chen, Changgui Li, Christopher G. Proud, Tao Jiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 6, Pp 2403-2424 (2023)
The occurrence of obesity has increased across the whole world. Many epidemiological studies have indicated that obesity strongly contributes to the development of cancer, cardiovascular diseases, type 2 diabetes, liver diseases and other disorders,
Externí odkaz:
https://doaj.org/article/a1fe8e7190194c52ad76b9f2541109f8
Autor:
Tianmiao Li, Han-Shen Tae, Jiazhen Liang, Zixuan Zhang, Xiao Li, Tao Jiang, David J. Adams, Rilei Yu
Publikováno v:
Marine Drugs, Vol 22, Iss 3, p 110 (2024)
α-Conotoxins (α-CTxs) are structurally related peptides that antagonize nicotinic acetylcholine receptors (nAChRs), which may serve as new alternatives to opioid-based treatment for pain-related conditions. The non-natural amino acid analogues of
Externí odkaz:
https://doaj.org/article/fdcad9f4547f4144bbd334774b81790c
Autor:
Qin Dou, Jin Yuan, Rilei Yu, Jiahui Yang, Jiayi Wang, Yuxiang Zhu, Jing Zhong, Hongan Long, Zhiqing Liu, Xianghong Wang, Yuying Li, Yichen Xiao, Jiazhen Liang, Xiao‐Hua Zhang, Yan Wang
Publikováno v:
mLife, Vol 1, Iss 4, Pp 428-442 (2022)
Abstract Antibiotic resistance in gram‐negative pathogens has become one of the most serious global public health threats. The role of the N‐acyl homoserine lactone (AHL)‐mediated signaling pathway, which is widespread in gram‐negative bacter
Externí odkaz:
https://doaj.org/article/ff82ec9ecabe4e43864ee5e018bfe6ab
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Marine natural product (MNP) entity property information is the basis of marine drug development, and this entity property information can be obtained from the original literature. However, the traditional methods require several manual annotations,
Externí odkaz:
https://doaj.org/article/4a79f87f22264c2db64afa5e6a98977f
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114115- (2023)
Phosphoglycerate kinase 1(PGK1) is an important enzyme in the metabolic glycolysis pathway. Nowadays, PGK1 is an appealing therapeutic target for multiple cancers. However, no effective inhibitor of PGK1 has been reported. In this study, we demonstra
Externí odkaz:
https://doaj.org/article/cfa532b80a8a438ebf28e3df2f8a0d5c
Publikováno v:
Cancer Biology & Medicine, Vol 19, Iss 4, Pp 486-503 (2022)
Objective: Glycogen synthase kinase-3β (GSK3β) has been recognized as a suppressor of Wnt/β-catenin signaling, which is critical for the stemness maintenance of breast cancer stem cells. However, the regulatory mechanisms of GSK3β protein express
Externí odkaz:
https://doaj.org/article/769c1636bb7c4ee7a9aa23bcfc7d9558
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9553 (2023)
Transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel, can be directly activated by oxidants through cysteine modification. However, the patterns of cysteine modification are unclear. Structural analysis showed that the fre
Externí odkaz:
https://doaj.org/article/acb92c772d974d10a28b3f09050f3a02
Autor:
Chaoming Wang, Jinman Zhang, Xianfeng Wei, Mengke Yang, Weiping Ma, Rilei Yu, Ming Liu, Tao Jiang
Publikováno v:
Marine Drugs, Vol 21, Iss 5, p 314 (2023)
Multidrug resistance (MDR) caused by ATP-Binding Cassette Subfamily B Member 1 (ABCB1, P-glycoprotein, P-gp) is a major barrier for the success of chemotherapy in clinics. In this study, we designed and synthesized a total of 19 Lissodendrins B analo
Externí odkaz:
https://doaj.org/article/436ab0faf6174389a6f9019a783e26f8
Autor:
Shuo Wang, Peter Bartels, Cong Zhao, Arsalan Yousuf, Zhuguo Liu, Shuo Yu, Anuja R. Bony, Xiaoli Ma, Qin Dai, Ting Sun, Na Liu, Mengke Yang, Rilei Yu, Weihong Du, David J. Adams, Qiuyun Dai
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
A novel 4/8 subtype α-conotoxin, Vt1.27 (NCCMFHTCPIDYSRFNC-NH2), was identified from Conus vitulinus in the South China Sea by RACE methods. The peptide was synthesized and structurally characterized. Similar to other α-conotoxins that target neuro
Externí odkaz:
https://doaj.org/article/3b40fc49ed124c818c7fb0be3c511e37