Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rikus Botha"'
Autor:
Kathleen G. Mountjoy, Alexandre Caron, Kristina Hubbard, Avik Shome, Angus C. Grey, Bo Sun, Sarah Bould, Martin Middleditch, Beau Pontré, Ailsa McGregor, Paul W.R. Harris, Renata Kowalczyk, Margaret A. Brimble, Rikus Botha, Karen M.L. Tan, Sarah J. Piper, Christina Buchanan, Syann Lee, Anthony P. Coll, Joel K. Elmquist
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 207-216 (2018)
Objective: Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy bala
Externí odkaz:
https://doaj.org/article/97ac5cda40d14be9b1b3a08f94082f7b
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140320 (2015)
MRAP1 but not MRAP2, is essential for melanocortin receptor 2 functional expression. Human MRAP1 splice variant (hMRAPα) and human MRAP2 (hMRAP2) also interact with the other melanocortin receptor subtypes in vitro, although the physiological signif
Externí odkaz:
https://doaj.org/article/d9287c8bd7a54329acaa544ca75c0c9e
Publikováno v:
Journal of Molecular Endocrinology.
The human melanocortin-4 receptor plays a critical role regulating energy homeostasis. Studies on obesogenic hMC4R variants have not yet revealed how human melanocortin-4 receptor maintains body weight. Here, we identified a signaling profile for obe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e61bbd5a6b6163532b292ea503b7bf72
https://doi.org/10.1530/jme-23-0008
https://doi.org/10.1530/jme-23-0008
Publikováno v:
Journal of the Endocrine Society
The human melanocortin 4 receptor (hMC4R) plays a critical role in the regulation of energy balance with more than 150 distinct human obesity-associated mutations. Most exhibit defective MC4R functionality but six have been reported to associate with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13e0b9c4c972cadd5eef681ebaf4e41
http://europepmc.org/articles/PMC7207459
http://europepmc.org/articles/PMC7207459
Publikováno v:
Journal of Molecular Endocrinology. 50:217-227
Human melanocortin 2 receptor accessory protein 1(hMRAPa) is essential for human melanocortin 2 receptor (hMC2R)-regulated adrenal steroidogenesis. hMRAPa enhances hMC2R N-linked glycosylation and maturation, promotes hMC2R cell surface expression an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c4ee8106b15d592201f77d2273dcea
https://doi.org/10.1530/jme-12-0220
https://doi.org/10.1530/jme-12-0220
Publikováno v:
Journal of molecular endocrinology. 50(2)
Human melanocortin 2 receptor accessory protein (hMRAPa) is hypothesised to have functions beyond promoting human melanocortin 2 receptor (hMC2R) functional expression. To understand these potential functions, we exogenously co-expressed hMRAPa-FLAG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad411e035388d5a1de5e3e39213800d1
https://pubmed.ncbi.nlm.nih.gov/23296982
https://pubmed.ncbi.nlm.nih.gov/23296982
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140320 (2015)
PLoS ONE
PLoS ONE
MRAP1 but not MRAP2, is essential for melanocortin receptor 2 functional expression. Human MRAP1 splice variant (hMRAPα) and human MRAP2 (hMRAP2) also interact with the other melanocortin receptor subtypes in vitro, although the physiological signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c779764e5a4bd4459f9c226367fac2
https://doi.org/10.1371/journal.pone.0140320
https://doi.org/10.1371/journal.pone.0140320