Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Riku Das"'
Publikováno v:
eJHaem, Vol 4, Iss 3, Pp 738-744 (2023)
Abstract Background: DNA hypermethylation and instability due to inactivation mutations in Ten–eleven translocation 2 (TET2) is a key biomarker of hematological malignancies. This study aims at characterizing two intronic noncanonical splice‐site
Externí odkaz:
https://doaj.org/article/3e649e4777dd423db42321de4ec6726c
Publikováno v:
Cancers; Volume 14; Issue 19; Pages: 4814
Background and aims: The MET exon 14 skipping (METex14) is an oncogenic driver mutation that provides a therapeutic opportunity in non-small cell lung cancer (NSCLCs) patients. This event often results from sequence changes at the MET canonical splic
Autor:
Katarzyna Bialkowska, Mitali Das, Marvin T. Nieman, Edward F. Plow, Lahoucine Izem, Elzbieta Pluskota, Riku Das
Publikováno v:
Journal of Thrombosis and Haemostasis. 19:941-953
Objective Plasminogen/plasmin is a serine protease system primarily responsible for degrading fibrin within blood clots. Plasminogen mediates its functions by interacting with plasminogen receptors on the cell surface. H2B, one such plasminogen recep
Autor:
Ganapati H. Mahabeleshwar, Jeffrey A. Deiuliis, Sanjay Rajagopalan, Riku Das, Diana L. Ramirez-Bergeron, Gun Dong Kim, Jixin Zhong, Xiaoquan Rao
Publikováno v:
Molecular and cellular biology. 38(5)
Macrophages are strategically distributed in mammalian tissues and play an essential role in priming the immune response. However, macrophages need to constantly strike a balance between activation and inhibition states to avoid a futile inflammatory
Autor:
Patrick M. Hutchins, Edward F. Plow, Tomas Vaisar, Nathalie Pamir, Chongren Tang, Santica M. Marcovina, Graziella E. Ronsein, Godfrey S. Getz, Hao Wei, Jay W. Heinecke, Volker Schuster, Richard B. Weinberg, Riku Das, Marlys L. Koschinsky, David A. Dichek, Catherine A. Reardon
Using genetic and biochemical approaches, we investigated proteins that regulate macrophage cholesterol efflux capacity (CEC) and ABCA1-specific CEC (ABCA1 CEC), 2 functional assays that predict cardiovascular disease (CVD). Macrophage CEC and the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa081f6b8e3de4f89e9802b05a8e07b2
https://europepmc.org/articles/PMC5543924/
https://europepmc.org/articles/PMC5543924/
Autor:
Ganapati H. Mahabeleshwar, Riku Das, Goutham Narla, Dipali A. Date, Mukesh K. Jain, Daniel I. Simon
Publikováno v:
Journal of Biological Chemistry. 289:10318-10329
Accumulating evidence supports the importance of macrophage plasticity in a broad spectrum of biological processes operative in health and disease. A major locus of control regulating macrophage polarization is at the transcriptional level, and sever
Autor:
Ganapati H. Mahabeleshwar, Sharon A. McClellan, Gun-Dong Kim, Linda D. Hazlett, Lediana Goduni, Riku Das
Publikováno v:
The Journal of biological chemistry. 291(40)
Macrophages are the predominant innate immune cells recruited to tissues following injury or infection. These early-responding, pro-inflammatory macrophages play an essential role in the amplification of inflammation. However, macrophage pro-inflamma
Publikováno v:
Journal of Biomedicine and Biotechnology
Journal of Biomedicine and Biotechnology, Vol 2012 (2012)
Journal of Biomedicine and Biotechnology, Vol 2012 (2012)
Plasminogen and plasmin tether to cell surfaces through ubiquitously expressed and structurally quite dissimilar family of proteins, as well as some nonproteins, that are collectively referred to as plasminogen receptors. Of the more than one dozen p
Autor:
Edward F. Plow, Riku Das
Publikováno v:
Journal of Thrombosis and Haemostasis. 9:339-349
Summary. Background: Plasminogen (Plg) binding to cell surface Plg receptors (Plg-Rs) on the surface of macrophages facilitates Plg activation and migration of these cells. Histone H2B (H2B) acts as a Plg-R and its cell surface expression is up-regul
Publikováno v:
Circulation Research. 105:167-175
L-type Ca 2+ channel (LTCC) blockers, represented by amlodipine and verapamil, are widely used antihypertensive drugs that also have antiinflammatory activities. Plasminogen (Plg) is an important mediator of macrophage recruitment, and this role depe