Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Rikta Saha"'
Publikováno v:
RSC Advances. 5:12807-12820
Using novel hybrid molecules for the treatment of tuberculosis is one of the latest approaches. Keeping this concept in mind, thirty two hybrid compounds were synthesized, with pyrrole as one of the moieties, clubbed to coumarin, ibuprofen and isonia
Publikováno v:
Medicinal Chemistry Research. 24:879-890
3-[(2-Chloroquinolin-3-yl) methylene]-5-phenylfuran-2(3H)-one derivatives (6a–j and 7a–j) have been synthesized and evaluated for their antimalarial activity. Three compounds 7d, 7f, and 7g showed excellent activity (0.50–0.72 µg/mL). In addit
Autor:
Omprakash Tanwar, Mohammad Mumtaz Alam, Rikta Saha, Akranth Marella, Mymoona Akhter, M. S. Zaman
Publikováno v:
Medicinal Chemistry Research. 22:5153-5166
PDE-IV is one of the important targets in the treatment of asthma, COPD, and rheumatoid arthritis. In the search for novel PDE-IV inhibitors a 3D-QSAR study was performed on PDE-IV inhibitors by means of pharmacophore mapping using PHASE, Schrodinger
Publikováno v:
Medicinal Chemistry Research. 21:202-211
A 3D-QSAR study on amino-substituted pyrido[3,2b]pyrazinones as PDE-5 inhibitors was successfully performed by means of pharmacophore mapping using PHASE module of Schrodinger-9. The 3D-QSAR obtained from AADHRR-183 hypothesis was found to be statist
Publikováno v:
Journal of Physical Organic Chemistry. 21:30-33
This theoretical study attempts to find out similarity between metformin and glitazone class of antidiabetic drugs. It was found that some tautomeric forms of both metformin and thiazolidinedione ring of glitazones have similar molecular electrostati
Autor:
Mymoona Akhter, Rikta Saha, Omprakash Tanwar, Mohammad Mumtaz Alam, Shah Alam Khan, M. S. Zaman
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(3)
A planned 3D-pharmacophore mapping was carried out on the basis of chemical features associated with known Stf0 inhibitors. Four models (model 1–4) were obtained after GASP (Genetic Algorithm Similarity Program) refinement of seven models (D-1 to D
Autor:
Mohammad Mumtaz, Alam, Akranth, Marella, Mymoona, Akhtar, Asif, Husain, Mohammad Shahar, Yar, Mohammad, Shaquiquzzaman, Om Prakash, Tanwar, Rikta, Saha, Suruchi, Khanna, Syed, Shafi
Publikováno v:
Acta poloniae pharmaceutica. 70(3)
A series of pyrazolo[3,4-b]quinolines have been synthesized using one-pot water mediated synthetic route under microwave irradiation involving the condensation of 2-chloroquinoline-3-carbaldehydes with semicarbazide or 2,4-dinitrophenyl hydrazine. Th
Autor:
Mymoona Akhter, Mohammad Mumtaz Alam, Md. Shaquiquzzaman, Akranth Marella, Md. Rahmat Ali, Omprakash Tanwar, Rikta Saha, Md. Tauquir Alam
Publikováno v:
Mini reviews in medicinal chemistry. 13(6)
Pyrazoline is an important five membered nitrogen heterocycle, which has been extensively researched upon. The ring is quite stable and has inspired chemists to carry out various structural variations in the ring. This has propelled the development o
Autor:
Mohammad Ali, Mohammad Mumtaz Alam, Mymoona Akhter, Akranth Marella, Mohammad Shaquiquzzaman, Sandeep Srivastava, Omprakash Tanwar, Rikta Saha
Publikováno v:
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. 21(1)
Quinoline or 1-aza-naphthalene is a weak tertiary base. Quinoline ring has been found to possess antimalarial, anti-bacterial, antifungal, anthelmintic, cardiotonic, anticonvulsant, anti-inflammatory, and analgesic activity. Quinoline not only has a
Publikováno v:
Mini reviews in medicinal chemistry. 13(7)
Among the plethora of heterocyclic nucleus discovered, the oxadiazoles have also been explored extensively. The oxadiazole structure has been demonstrated to bear important biological activities such as anti-cancer, antiinflammatory, anti-tuberculosi