Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Rikki N. Waterhouse"'
Autor:
Thomas Lee Collier, Marc D. Normandin, Nickeisha A. Stephenson, Eli Livni, Steven H. Liang, Dustin W. Wooten, Shadi A. Esfahani, Michael G. Stabin, Umar Mahmood, Jianqing Chen, Wei Wang, Kevin Maresca, Rikki N. Waterhouse, Georges El Fakhri, Paul Richardson, Neil Vasdev
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Lorlatinib—a ROS1/ALK inhibitor—is currently undergoing clinical trials for the treatment of non-small cell lung cancers. Here the authors develop synthetic routes to11C- and 18F-labelled lorlatinib, with subsequent PET imaging showing good blood
Externí odkaz:
https://doaj.org/article/c6a81b2a14fd4e259767853846c7c586
Autor:
T. Lee Collier PhD, Kevin P. Maresca PhD, Marc D. Normandin PhD, Paul Richardson PhD, Timothy J. McCarthy PhD, Steven H. Liang PhD, Rikki N. Waterhouse PhD, Neil Vasdev PhD
Publikováno v:
Molecular Imaging, Vol 16 (2017)
The Massachusetts General Hospital Radiochemistry Program, in collaboration with Pfizer, has developed unique 11 C and 18 F-labeling strategies to synthesize isotopologs of lorlatinib (PF-06463922) which is undergoing phase III clinical trial investi
Externí odkaz:
https://doaj.org/article/27b95e925c124ac8b0c0adf8168291a3
Autor:
Nicholas DeMartinis, Sanela Tarabar, Yiyun Huang, Anindita Banerjee, David Labaree, Shu-fei Lin, Nabeel Nabulsi, Rikki N. Waterhouse, Adam Ogden, Richard E. Carson, Mika Naganawa, Jim Ropchan
Publikováno v:
Journal of Nuclear Medicine. 57:1388-1395
This was a first-in-human study of the novel phosphodiesterase-2A (PDE2A) PET ligand 18F-PF-05270430. The primary goals were to determine the appropriate tracer kinetic model to quantify brain uptake and to examine the within-subject test–retest va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4de1dc300d141360515dde6463905f1
https://doi.org/10.2967/jnumed.115.166850
https://doi.org/10.2967/jnumed.115.166850
Autor:
Chen Jianqing, David A. Griffith, Alex Zheleznyak, David A. Tess, Nilantha Bandara, Suzanne E. Lapi, Rikki N. Waterhouse, Kaavya Cherukuri, Chris Limberakis
Publikováno v:
Molecular Imaging and Biology. 18:90-98
Copper-64 (Cu-64) and Galium-68 (Ga-68) radiolabeled DO3A and NODA conjugates of exendin-4 were used for preclinical imaging of pancreatic β cells via targeting of glucagon-like peptide-1 receptor (GLP-1R).DO3A-VS- and NODA-VS-tagged Cys(40)exendin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d914516488c7a613489fea7570def9d7
https://doi.org/10.1007/s11307-015-0861-5
https://doi.org/10.1007/s11307-015-0861-5
Autor:
Marc D. Normandin, Rikki N. Waterhouse, Neil Vasdev, Paul G. Richardson, Kevin P. Maresca, Timothy J. McCarthy, Steven H. Liang, T. Lee Collier
Publikováno v:
Nature Communications
Molecular Imaging, Vol 16 (2017)
Molecular Imaging, Vol 16 (2017)
Lorlatinib (PF-06463922) is a next-generation small-molecule inhibitor of the orphan receptor tyrosine kinase c-ros oncogene 1 (ROS1), which has a kinase domain that is physiologically related to anaplastic lymphoma kinase (ALK), and is undergoing Ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594b178b4d7ee72b308c4bb37314bc12
https://pubmed.ncbi.nlm.nih.gov/28594000
https://pubmed.ncbi.nlm.nih.gov/28594000
Autor:
Wei Wang, Marc D. Normandin, Nickeisha A. Stephenson, Jianqing Chen, Paul G. Richardson, Thomas Lee Collier, Rikki N. Waterhouse, Neil Vasdev, Kevin P. Maresca, Georges El Fakhri, Eli Livni, Dustin Wooten, Michael G. Stabin, Shadi Abdar Esfahani, Steven H. Liang, Umar Mahmood
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Lorlatinib (PF-06463922) is a next-generation small-molecule inhibitor of the orphan receptor tyrosine kinase c-ros oncogene 1 (ROS1), which has a kinase domain that is physiologically related to anaplastic lymphoma kinase (ALK), and is undergoing Ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228b759c7d85b5551a9ec7b741b0f9d3
https://doi.org/10.1038/ncomms15761
https://doi.org/10.1038/ncomms15761
Autor:
Wichana Chamroonrat, Terence G. Hamill, James Robert Brašić, Michael Stabins, P. David Mozley, Rikki N. Waterhouse, Hiroto Kuwabara, Robert F. Dannals, Dean F. Wong, Daniel P. Holt, Jongho Kim
Publikováno v:
Journal of Nuclear Medicine. 54:388-396
Identification of safe and valid PET radioligands for metabotropic glutamate receptor, type 5 (mGluR5), is essential to measure changes in brain mGluR5 in neuropsychiatric disorders, to confirm central mGluR5 occupancy of drug candidates, and to guid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f257288625637892f190fbdcecf300ac
https://doi.org/10.2967/jnumed.112.107995
https://doi.org/10.2967/jnumed.112.107995
Autor:
Gad Friedman, Avi Cohen, Hagit Grimberg, Anat Shirvan, Gunnar Antoni, Galit Levin, Rikki N. Waterhouse, Luckner G. Ulysse, Ayelet Reshef, Ilan Ziv
Publikováno v:
Journal of Nuclear Medicine. 49:1520-1528
Clinical molecular imaging of apoptosis is a highly desirable yet unmet challenge. Here we provide the first report on 18 F-labeled 5-fluoropentyl-2-methyl-malonic acid (18F-ML-10), a smallmolecule, 18 F-labeled PET tracer for the imaging of apoptosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47082a2dc7b2b243fd1c8dd7d404071d
https://doi.org/10.2967/jnumed.107.043919
https://doi.org/10.2967/jnumed.107.043919
Autor:
Balagopal Lakshmi, Jun Zhao, Rikki N. Waterhouse, Mei-Ping Kung, Hank F. Kung, Brian P. Lieberman
Publikováno v:
Nuclear Medicine and Biology. 35:43-52
Alterations in serotonin and norepinephrine neuronal functions have been observed in patients with major depression. Several antidepressants bind to both serotonin transporters and norepinephrine transporters (NET). The ability to image NET in the hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59beb9ef808479ea3eecbc375c468b52
https://doi.org/10.1016/j.nucmedbio.2007.08.007
https://doi.org/10.1016/j.nucmedbio.2007.08.007
Publikováno v:
Synapse. 61:540-546
Sigma-1 receptors are widely expressed in the mammalian brain and also in organs of the immune, endocrine and reproductive systems. Based on behavioral and pharmacological assessments, sigma-1 receptors are important in memory and cognitive processes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a484894dc30c70d0231d09d881457c
https://doi.org/10.1002/syn.20369
https://doi.org/10.1002/syn.20369