Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Rikke Sindet"'
Autor:
Mogens Trolle Larsen, Venkatarathnam Reddy Nasipireddy, Martin A. Carnerup, Paola Lovato, Jimmi Gerner Seitzberg, Andreas Ritzen, Burhardt Mia Norreskov, Thomas Vifian, Anders Jerre, Tue Heesgaard Jepsen, Jens Christian Højland Larsen, Rikke Sindet, Sanjay Rai, Bettina Borreschmidt Hansen, Christina Mølck
Publikováno v:
Journal of medicinal chemistry. 63(13)
Herein, we report the discovery of a series of JAK1-selective kinase inhibitors with high potency and excellent JAK family subtype selectivity. A fragment screening hit 1 with a pyrazolopyridone core and a JAK1 bias was selected as the starting point
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886914e454d2cc366a197455d0cf4752
https://pubmed.ncbi.nlm.nih.gov/32462873
https://pubmed.ncbi.nlm.nih.gov/32462873
Autor:
Andreas Ritzen, Christoffer Bundgaard, Robbin Brodbeck, Rikke Sindet, Nannette Svendsen, Morten Hentzer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3275-3278
This Letter describes the discovery of a novel series of mGluR5 positive allosteric modulators (PAMs). The lead compound, 11c, exhibits excellent potency (EC(50)=30 nM) in vitro, and reaches high brain levels in both rats and mice after oral administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203a7eedf537646a5221f2061fac8287
https://doi.org/10.1016/j.bmcl.2009.04.095
https://doi.org/10.1016/j.bmcl.2009.04.095