Lack of Integration of Research in Clinical Practice: A Qualitative Study of Clinical Academics’ Challenges in the Workplace Environment of Danish Hospitals

Autor: Janet Froulund Jensen, Cecilie Froulund Jensen, Malene Roland Pedersen, Rikke Leth-Larsen, Marit Christensen, Ditte Høgsgaard

Publikováno v: International Medical Education, Vol 3, Iss 3, Pp 331-345 (2024)

Clinical academics experience dual workplaces, namely the clinical and the research environment. However, working in two workplaces leads to difficulties in forming an integrated identity, affecting a person’s work environment and well-being. The a

Externí odkaz: https://doaj.org/article/2f96d894c78a47118ebe433eaa9162e2

Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome

Autor: Sidse Ehmsen, Martin H. Pedersen, Guisong Wang, Mikkel G. Terp, Amina Arslanagic, Brian L. Hood, Thomas P. Conrads, Rikke Leth-Larsen, Henrik J. Ditzel

Publikováno v: Cell Reports, Vol 27, Iss 13, Pp 3927-3938.e6 (2019)

Summary: Tumor eradication may be greatly improved by targeting cancer stem cells (CSCs), as they exhibit resistance to conventional therapy. To gain insight into the unique biology of CSCs, we developed patient-derived xenograft tumors (PDXs) from E

Externí odkaz: https://doaj.org/article/8e8a496aa1f64ed4a56531ee422573a6

MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit

Autor: Christina Bjerre, Jens S. Andersen, Sanne Løkkegaard, Martin V. Bennetzen, Daniel Elias, Martin Bak, Tommy Fornander, Linda S. Lindström, Tove Kirkegaard, Carla Maria Lourenco Alves, Lene E. Johansen, Anne E. Lykkesfeldt, Anne Vibeke Lænkholm, Rikke Leth-Larsen, Laura J. Esserman, Olle Stål, Henrik J. Ditzel, Morten F. Gjerstorff, Bo Nordenskjöld, Henriette Vever

Publikováno v: NPJ breast cancer, vol 7, iss 1
Løkkegaard, S, Elias, D, Alves, C L, Bennetzen, M V, Lænkholm, A-V, Bak, M, Gjerstorff, M F, Johansen, L E, Vever, H, Bjerre, C, Kirkegaard, T, Nordenskjöld, B, Fornander, T, Stål, O, Lindström, L S, Esserman, L J, Lykkesfeldt, A E, Andersen, J S, Leth-Larsen, R & Ditzel, H J 2021, ' MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit ', npj Breast Cancer, vol. 7, no. 1, pp. 2 . https://doi.org/10.1038/s41523-020-00210-8
npj Breast Cancer, Vol 7, Iss 1, Pp 1-15 (2021)
NPJ Breast Cancer
Løkkegaard, S, Elias, D, Alves, C L, Bennetzen, M V, Lænkholm, A V, Bak, M, Gjerstorff, M F, Johansen, L E, Vever, H, Bjerre, C, Kirkegaard, T, Nordenskjöld, B, Fornander, T, Stål, O, Lindström, L S, Esserman, L J, Lykkesfeldt, A E, Andersen, J S, Leth-Larsen, R & Ditzel, H J 2021, ' MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit ', npj Breast Cancer, vol. 7, 2 . https://doi.org/10.1038/s41523-020-00210-8

Resistance to endocrine therapy in estrogen receptor-positive (ER+) breast cancer is a major clinical problem with poorly understood mechanisms. There is an unmet need for prognostic and predictive biomarkers to allow appropriate therapeutic targetin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98ea350b249a8cffb0597a2fbcc9544
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-173067

Cholesterol Biosynthesis Is a Key Feature of Cancer Stem Cells as Revealed by Proteomic Comparison of Breast Cancer Tissue, Corresponding PDXs and Mammospheres

Autor: Mikkel G. Terp, Rikke Leth-Larsen, Amina Arslanagic, Henrik J. Ditzel, Thomas P. Conrads, Brian L. Hood, Martin Haar Pedersen, Guisong Wang, Sidse Ehmsen

Publikováno v: SSRN Electronic Journal.

Cancer stem cells (CSCs) comprise a small subpopulation of undifferentiated cancer cells with the ability to self-renew and give rise to the heterogeneous cancer cell lineages that form tumorous masses. Thus, tumor eradication may be greatly improved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ed9b68644b3d90da1f802745fd22d8c
https://doi.org/10.2139/ssrn.3281654

Downregulation of antigen presentation-associated pathway proteins is linked to poor outcome in triple-negative breast cancer patient tumors

Autor: Brian L. Hood, Martin Haar Pedersen, Thomas P. Conrads, Henrik J. Ditzel, Hans Christian Beck, Rikke Leth-Larsen

Publikováno v: Pedersen, M H, Hood, B L, Beck, H C, Conrads, T P, Ditzel, H & Leth-Larsen, R 2017, ' Downregulation of antigen presentation-associated pathway proteins is linked to poor outcome in triple-negative breast cancer patient tumors ', OncoImmunology, vol. 6, no. 5, e1305531 . https://doi.org/10.1080/2162402X.2017.1305531
OncoImmunology, Vol 6, Iss 5 (2017)

Triple-negative breast cancer (TNBC) is a heterogeneous subtype with varying disease outcomes. Tumor-infiltrating lymphocytes (TILs) are frequent in TNBC and have been shown to correlate with outcome, suggesting an immunogenic component in this subty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bacfe4312d7e8c169187d765e6eccc
https://portal.findresearcher.sdu.dk/da/publications/af0c0889-c985-476b-91d5-2e7fd8da4d3b