Výsledky vyhledávání - "Rikke Hilker"

Akademický článek

Reward Processing as an Indicator of Vulnerability or Compensatory Resilience in Psychoses? Results From a Twin Study

Autor: Mette Ødegaard Nielsen, Egill Rostrup, Rikke Hilker, Christian Legind, Simon Anhøj, Trevor William Robbins, Barbara J. Sahakian, Birgitte Fagerlund, Birte Glenthøj

Publikováno v: Biological Psychiatry Global Open Science, Vol 3, Iss 1, Pp 47-55 (2023)

Background: Findings of reward disturbances in unaffected relatives of patients with schizophrenia suggest reward disturbances as an endophenotype for schizophrenia. Twin studies, where 1 twin has been diagnosed with a schizophrenia spectrum disorder

Externí odkaz: https://doaj.org/article/71af95785caf4365a5beae1b75940fea

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Akademický článek

Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin Register

Autor: Rikke Hilker, Dorte Helenius, Birgitte Fagerlund, Axel Skytthe, Kaare Christensen, Thomas M. Werge, Merete Nordentoft, Birte Glenthøj

Publikováno v: EBioMedicine, Vol 18, Iss C, Pp 320-326 (2017)

Background: Early age at illness onset has been viewed as an important liability marker for schizophrenia, which may be associated with an increased genetic vulnerability. A twin approach can be valuable, because it allows for the investigation of sp

Externí odkaz: https://doaj.org/article/13db1d8612324fb488c1e7e97378dd15

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The relative and interactive impact of multiple risk factors in schizophrenia spectrum disorders: a combined register-based and clinical twin study

Autor: Rikke Hilker, Simon Anhøj, Cecilie K Lemvigh, Rachel M. Brouwer, Birgitte Fagerlund, Christos Pantelis, L. Baandrup, B. Glenthøj

Publikováno v: Psychological Medicine. 53:1266-1276

BackgroundResearch has yielded evidence for genetic and environmental factors influencing the risk of schizophrenia. Numerous environmental factors have been identified; however, the individual effects are small. The additive and interactive effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca768f93c1a38eeb3987c5970c8bb705
https://doi.org/10.1017/s0033291721002749

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Heritability of specific cognitive functions and associations with schizophrenia spectrum disorders using CANTAB: a nation-wide twin study

Autor: Barbara J. Sahakian, Birgitte Fagerlund, Rachel M. Brouwer, Cecilie K Lemvigh, Trevor W. Robbins, Rikke Hilker, Christos Pantelis, Maria Høj Jensen, Simon Anhøj, Christian Legind, Birte Glenthøj

Publikováno v: Psychological Medicine. 52:1101-1114

BackgroundMany cognitive functions are under strong genetic control and twin studies have demonstrated genetic overlap between some aspects of cognition and schizophrenia. How the genetic relationship between specific cognitive functions and schizoph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cd2dfc19513b7a2d42f4da7a2fa715
https://doi.org/10.1017/s0033291720002858

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Heritability of Cerebral Blood Flow and the Correlation to Schizophrenia Spectrum Disorders: A Pseudo-continuous Arterial Spin Labeling Twin Study

Autor: Simon Anhøj, Rikke Hilker, Christian Legind, Rachel M. Brouwer, Maria H. Jensen, Birgitte Fagerlund, René C.W. Mandl, Hilleke E. Hulshoff Pol, Brian V. Broberg, Bjørn H Ebdrup, Birte Glenthøj, Egill Rostrup

Publikováno v: Schizophr Bull

Whether aberrant cerebral blood flow (CBF) in schizophrenia is affected by genetic influences, and consequently a potential marker for genetic susceptibility, is unknown. Our aims were to determine the heritability of CBF in thalamic, frontal, and st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c071ad48761b31267247a27b571f03
https://doi.org/10.1093/schbul/sbz007

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Heritability of Memory Functions and Related Brain Volumes: A Schizophrenia Spectrum Study of 214 Twins

Autor: Trevor W. Robbins, Birgitte Fagerlund, Louise Baruël Johansen, Barbara J. Sahakian, Christian Legind, Hilleke E. Hulshoff Pol, Cecilie K Lemvigh, Rachel M. Brouwer, Bjørn H Ebdrup, Birte Glenthøj, Simon Anhøj, Christos Pantelis, Rikke Hilker

Publikováno v: Lemvigh, C, Brouwer, R M, Sahakian, B J, Robbins, T W, Johansen, L, Legind, C, Anhøj, S, Hilker, R W, Hulshoff Pol, H E, Ebdrup, B, Pantelis, C, Glenthøj, B Y & Fagerlund, B 2020, ' Heritability of Memory Functions and Related Brain Volumes: A Schizophrenia Spectrum Study of 214 Twins ', Schizophrenia Bulletin Open, vol. 1, no. 1, sgaa066 . https://doi.org/10.1093/schizbullopen/sgaa066

BackgroundMemory performance is heritable and shares partial genetic etiology with schizophrenia. How the genetic overlap between memory and schizophrenia is related to intelligence (IQ) and brain volumes has not been formally tested using twin model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f85bf590aaf55aae670382f19790339
https://doi.org/10.1093/schizbullopen/sgaa066

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Real-world effectiveness of clozapine for intellectual disability: Results from a mirror-image and a reverse-mirror-image study

Autor: Rikke Hilker, Dan Siskind, Jimmi Nielsen, Christopher Rohde

Publikováno v: Rohde, C, Hilker, R, Siskind, D & Nielsen, J 2018, ' Real-world effectiveness of clozapine for intellectual disability : Results from a mirror-image and a reverse-mirror-image study ', Journal of Psychopharmacology, vol. 32, no. 11, pp. 1197-1203 . https://doi.org/10.1177/0269881118783322

Background: Comorbid mental illness is common in patients with intellectual disability. Antipsychotics are widely used for these conditions, but the effect of clozapine remains largely unknown. Aims: We aimed to investigate the effectiveness of cloza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11b140bba23871fef6400c0deaf79b4
https://doi.org/10.1177/0269881118783322

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Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin Register

Autor: Dorte Helenius, Rikke Hilker, Birgitte Fagerlund, Merete Nordentoft, Kaare Christensen, Thomas Werge, Birte Glenthøj, Axel Skytthe

Publikováno v: EBioMedicine, Vol 18, Iss C, Pp 320-326 (2017)
EBioMedicine
Hilker, R W, Helenius, D, Fagerlund, B, Skytthe, A, Christensen, K, Werge, T M, Nordentoft, M & Glenthøj, B 2017, ' Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin Register ', EBioMedicine, vol. 18, pp. 320-326 . https://doi.org/10.1016/j.ebiom.2017.04.002

Background Early age at illness onset has been viewed as an important liability marker for schizophrenia, which may be associated with an increased genetic vulnerability. A twin approach can be valuable, because it allows for the investigation of spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a147f91d7895abae1014b055fca445e7
http://www.sciencedirect.com/science/article/pii/S2352396417301445

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T10. BIOMARKERS IN TREATMENT-RESISTANT SCHIZOPHRENIA; THE BITS STUDY (A STUDY PROTOCOL)

Autor: Rikke Hilker, Jimmi Nielsen, Mette Ødegaard Nielsen

Publikováno v: Schizophrenia Bulletin

Background Approximately 30% of patients diagnosed with schizophrenia do not respond to conventional antipsychotic therapy, however, around 30% of these patients will respond to treatment with clozapine. The remaining clozapine non-respondent patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0101eac72fc11434c8225746d442477a
http://europepmc.org/articles/PMC7233892

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