Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Rikinari Hanayama"'
Autor:
Yifan Li, Kouyuki Hirayasu, Gen Hasegawa, Yosei Tomita, Yuko Hashikawa, Ryosuke Hiwa, Hisashi Arase, Rikinari Hanayama
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The leukocyte immunoglobulin-like receptor (LILR) family, a group of primate-specific immunoreceptors, is widely expressed on most immune cells and regulates immune responses through interactions with various ligands. The inhibitory type, LILRB, has
Externí odkaz:
https://doaj.org/article/a2a077a9c15a42f3acd2408959b7da6a
Autor:
Hisano Kobayashi, Takayuki Shiba, Takeshi Yoshida, Dilireba Bolidong, Koroku Kato, Yoshiki Sato, Mao Mochizuki, Takafumi Seto, Shuichi Kawashiri, Rikinari Hanayama
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Methods that enable specific and sensitive quantification of small extracellular vesicles (sEVs) using flow cytometry are still under development. Aggregation or adsorption of antibodies causes sub-nano sized particles or non-specific bindin
Externí odkaz:
https://doaj.org/article/42baa733f84b4b4fa4ee911ac925d8df
Autor:
Kouyuki Hirayasu, Seik-Soon Khor, Yosuke Kawai, Mihoko Shimada, Yosuke Omae, Gen Hasegawa, Yuko Hashikawa, Hiromu Tanimoto, Jun Ohashi, Kazuyoshi Hosomichi, Atsushi Tajima, Hiroyuki Nakamura, Minoru Nakamura, Katsushi Tokunaga, Rikinari Hanayama, Masao Nagasaki
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Leukocyte immunoglobulin (Ig)-like receptors (LILRs) on human chromosome 19q13.4 encode 11 immunoglobulin superfamily receptors, exhibiting genetic diversity within and between human populations. Among the LILR genes, the genomic region surrounding L
Externí odkaz:
https://doaj.org/article/1df24c530cd145c0b338532826863cde
Autor:
Arisa Hori, Saori Toyoura, Miyu Fujiwara, Ren Taniguchi, Yasutaka Kano, Tomoyoshi Yamano, Rikinari Hanayama, Masafumi Nakayama
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109704- (2024)
Summary: In addition to cross-presentation, cross-dressing plays an important role in the induction of CD8+ T cell immunity. In the process of cross-dressing, conventional dendritic cells (DCs) acquire major histocompatibility complex class I (MHCI)
Externí odkaz:
https://doaj.org/article/905083a5f50048b1ad59d8b3cc304867
Autor:
Elma Sakinatus Sajidah, Keesiang Lim, Tomoyoshi Yamano, Goro Nishide, Yujia Qiu, Takeshi Yoshida, Hanbo Wang, Akiko Kobayashi, Masaharu Hazawa, Firli R. P. Dewi, Rikinari Hanayama, Toshio Ando, Richard W. Wong
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 11, Pp n/a-n/a (2022)
Abstract Small extracellular vesicles (sEVs) play a crucial role in local and distant cell communication. The intrinsic properties of sEVs make them compatible biomaterials for drug delivery, vaccines, and theranostic nanoparticles. Although sEV prot
Externí odkaz:
https://doaj.org/article/db5d580c3ded45efaec2701e8a6121c4
Autor:
Yunfei Ma, Takeshi Yoshida, Kazutaka Matoba, Katsuhiko Kida, Rito Shintani, Yingshi Piao, Jingchun Jin, Taito Nishino, Rikinari Hanayama
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Extracellular vesicles (EVs) are secreted from most cells and play important roles in cell–cell communication by transporting proteins, lipids, and nucleic acids. As the involvement of EVs in diseases has become apparent, druggable regulat
Externí odkaz:
https://doaj.org/article/2ddc367d5d854855b6999422bfd61b77
Autor:
Tomohisa Baba, Takeshi Yoshida, Yamato Tanabe, Tatsunori Nishimura, Soji Morishita, Noriko Gotoh, Atsushi Hirao, Rikinari Hanayama, Naofumi Mukaida
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Abstract Accumulating evidence indicates the presence of cytoplasmic DNAs in various types of malignant cells, and its involvement in anti-cancer drug- or radiotherapy-mediated DNA damage response and replication stress. However, the pathophysiologic
Externí odkaz:
https://doaj.org/article/ab9d156c7775481dba83492281d3a122
Autor:
Hiroki Yamaguchi, Hironori Kawahara, Noriyuki Kodera, Ayanori Kumaki, Yasutake Tada, Zixin Tang, Kenji Sakai, Kenjiro Ono, Masahito Yamada, Rikinari Hanayama
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Hereditary (variant) transthyretin amyloidosis (ATTRv amyloidosis), which is caused by variants in the transthyretin (TTR) gene, leads to TTR amyloid deposits in multiple organs and various symptoms such as limb ataxia, muscle weakness, and cardiac f
Externí odkaz:
https://doaj.org/article/020c1adaab57494fb4df86d057211ec1
Autor:
Rong Wang, Tadaaki Yamada, Kenji Kita, Hirokazu Taniguchi, Sachiko Arai, Koji Fukuda, Minoru Terashima, Akihiko Ishimura, Akihiro Nishiyama, Azusa Tanimoto, Shinji Takeuchi, Koshiro Ohtsubo, Kaname Yamashita, Tomoyoshi Yamano, Akihiro Yoshimura, Koichi Takayama, Kyoichi Kaira, Yoshihiko Taniguchi, Shinji Atagi, Hisanori Uehara, Rikinari Hanayama, Isao Matsumoto, Xujun Han, Kunio Matsumoto, Wei Wang, Takeshi Suzuki, Seiji Yano
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Cancer cells develop resistance to tyrosine kinase inhibitors targeting EGFR. Here, the authors explore the mechanism of resistance to one such inhibitor - osimertinib - and find that resistance is caused by increased expression and activation of the
Externí odkaz:
https://doaj.org/article/286176aadbbc411dbfd32550becc33c5
Autor:
Keesiang Lim, Goro Nishide, Takeshi Yoshida, Takahiro Watanabe‐Nakayama, Akiko Kobayashi, Masaharu Hazawa, Rikinari Hanayama, Toshio Ando, Richard W. Wong
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 14, Pp n/a-n/a (2021)
Abstract SARS‐CoV‐2 spike protein (S) binds to human angiotensin‐converting enzyme 2 (hACE2), allowing virus to dock on cell membrane follow by viral entry. Here, we use high‐speed atomic force microscopy (HS‐AFM) for real‐time visualizat
Externí odkaz:
https://doaj.org/article/a9e0dd1f6bb1402790cde631f7065ff5