Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Riki Stevenson"'
Autor:
Quanzhou Luo, Kenneth W. Walker, Qing Chen, Kannan Gunasekaran, Riki Stevenson, Jie Wen, Frederick W. Jacobsen, Shu-Yin Ho, Lynette Buck, Linda O. Narhi, Kristine M. Daris, Wei Wang, Jette Wypych, Hossein Salimi-Moosavi, Sterling Miller, Ling Liu, Cynthia Li
Publikováno v:
Journal of Biological Chemistry. 292:1865-1875
IgG isotypes can differentially bind to Fcγ receptors and complement, making the selection of which isotype to pursue for development of a particular therapeutic antibody important in determining the safety and efficacy of the drug. IgG2 and IgG4 is
Autor:
Madeline M. Fort, Nancy E. Everds, Mai Phuong Nguyen, Linda O. Narhi, Darcey Clark, Yan Bin Yu, Padma K. Narayanan, Nianyu Li, Yao Zhuang, Riki Stevenson, Kannan Gunasekaran, Jeanine L. Bussiere, Ling Liu, Kei Kim, Frederick W. Jacobsen
Publikováno v:
Journal of Biological Chemistry. 292:1876-1883
The stable effector functionLess (SEFL) antibody was designed as an IgG1 antibody with a constant region that lacks the ability to interact with Fcγ receptors. The engineering and stability and pharmacokinetic assessments of the SEFL scaffold is des
Autor:
Riki Stevenson, Louise Chen, Gregory C. Flynn, Thomas M. Dillon, Andrew M. Goetze, Gunasekaran Kannan, Xinzhao Grace Jiang, Tian Wang, Gang Huang, Robert Y.-T. Chou, Yaoqing Diana Liu
Publikováno v:
Molecular Immunology. 54:217-226
Human IgG2 antibodies contain three types of disulfide isoforms, classified by the number of Fab arms having disulfide links to the heavy chain hinge region. In the IgG2-B form, both Fab arms have interchain disulfide bonds to the hinge region, and i
Autor:
Ching He, Nancy Doyle, Erin Stevens, Padma K. Narayanan, Remi Jawando, Cen Xu, Nianyu Li, Madeline M. Fort, Kevin Salyers, Florence Poitout-Belissent, Riki Stevenson, Mai Phuong Nguyen, Katherine Sprugel, Vibha Jawa, Nancy E. Everds, Keith Bailey, Sam M Tran, Jacquelin Jolette
Publikováno v:
Toxicologic Pathology. 41:951-969
Cynomolgus monkeys dosed with a therapeutic monoclonal antibody (mAbY.1) at ≥50 mg/kg had unexpected acute thrombocytopenia (nadir ∼3,000 platelets/µl), sometimes with decreases in red cell mass. Increased activated macrophages, mitotic figures,
Autor:
Yatin R. Gokarn, Stephen R. Brych, Riki Stevenson, Rahul S. Rajan, Masazumi Matsumura, Heather Hultgen
Publikováno v:
Journal of Pharmaceutical Sciences. 99:764-781
Proteins are susceptible to degradation upon exposure to a variety of stresses during product manufacturing, transportation and storage. In this study, we investigated the aggregation properties of a monoclonal antibody during agitation stress. Agita
Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions
Autor:
Riki Stevenson, Quanzhou Luo, Marisa K. Joubert, Jette Wypych, Randal R. Ketchem, Linda O. Narhi
In this study, we characterized the chemical modifications in the monoclonal antibody (IgG(2)) aggregates generated under various conditions, including mechanical, chemical, and thermal stress treatment, to provide insight into the mechanism of prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d346eae7feaa06c08a29388383aa3d
https://europepmc.org/articles/PMC3137086/
https://europepmc.org/articles/PMC3137086/
Autor:
Heather Franey, Randal R. Ketchem, Osslund Timothy D, Min Shen, Gary Li, Feng He, Egor Trilisky, Deirdre Murphy Piedmonte, John Wendling, Francis Kinderman, Haruki Hasegawa, Riki Stevenson
Publikováno v:
The Journal of biological chemistry. 286(22)
Protein synthesis and secretion are essential to cellular life. Although secretory activities may vary in different cell types, what determines the maximum secretory capacity is inherently difficult to study. Increasing protein synthesis until reachi