Lung Deposition of Surfactant Delivered via a Dedicated Laryngeal Mask Airway in Piglets

Autor: Anders Nord, Doris Cunha-Goncalves, Rikard Linnér, Federico Bianco, Fabrizio Salomone, Francesca Ricci, Marta Lombardini, Massimo Micaglio, Daniele Trevisanuto, Valeria Perez-de-Sa

Publikováno v: Pharmaceutics, Vol 13, Iss 11, p 1858 (2021)

It is unknown if the lung deposition of surfactant administered via a catheter placed through a laryngeal mask airway (LMA) is equivalent to that obtained by bolus instillation through an endotracheal tube. We compare the lung deposition of surfactan

Externí odkaz: https://doaj.org/article/645dbdabab2e41f190b62eb4c1e0d7ae

Nebulization of High-Dose Poractant Alfa in Newborn Piglets on Nasal Continuous Positive Airway Pressure Yields Therapeutic Lung Doses of Phospholipids

Autor: Doris Cunha-Goncalves, Federico Bianco, Fabrizio Salomone, Anders Nord, Rikard Linner, Martin Schlun, Francesca Ricci

Publikováno v: American Journal of Perinatology. 39:1001-1007

Objective: It is not known how much surfactant must be nebulized to reach a lung dose of phospholipids equivalent to that obtained by the instillation of 200 mg/kg of surfactant. We aimed to assess the feasibility of nebulizing a high-dose of poracta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1425b5f8da832874e6e1a0d7d96a1f8
https://doi.org/10.1055/s-0040-1721392

A novel delivery system for supraglottic atomization allows increased lung deposition rates of pulmonary surfactant in newborn piglets

Autor: Ilaria Milesi, Raffaele Dellaca, Marco Di Castri, Emanuela Zannin, Federico Bianco, Anders Nord, Doris Cunha-Goncalves, Valeria Perez-de-Sa, Rikard Linner

Publikováno v: Pediatric Research

Background Earlier attempts to deliver effective lung doses of surfactant by aerosolization were unsuccessful, mostly because of technical shortcomings. We aimed at quantifying the lung deposition of poractant alfa with a new supraglottic delivery sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5ba49074ac22157f23a8ccbf637e11
https://doi.org/10.1038/s41390-019-0696-x

30th International Workshop on Surfactant Replacement, Stockholm, June 5-6, 2015: Abstracts

Autor: Doris Cunha-Goncalves, Dorothy Hehre, Mikael Norman, Frank van Bel, Eileen I. Chang, Anna Gudmundsdottir, Jonathan M. Davis, Megan O'Reilly, Robert Ross-Russell, Charles E. Wood, Thomas Alderliesten, Linda S. de Vries, Anna Curley, Valeria Perez-de-Sa, Eric S. Shinwell, Karin Källén, Petra M A Lemmers, Bernard Thébaud, Renato Machado Fiori, Julia Gunkel, Ola Didrik Saugstad, Steven H. Abman, Aaron Hamvas, Jessica W. Lo, Henry L. Halliday, Stefan Johansson, Willem Baerts, Sascha Meyer, Niranjan Thomas, Natanja Oosterom, Tricia J. Johnson, Janet L. Peacock, Etienne Ciantar, Paula P. Meier, Rikard Linner, Harold R. Bigger, Richard B. Parad, Yogeshwar Chakrapani, Tom F.W. Wolfs, Colin J Morley, Christian P. Speer, Humberto Holmer Fiori, O D Saugstad, Kajsa Bohlin, Tore Curstedt, Satz Mengensatzproduktion, Anna-Karin Edstedt Bonamy, Christopher D. Baker, Druckerei Stückle, Theodore Dassios, Mats Blennow, Dirk Bassler, Nisreen A Alwan, Cleide Suguihara, Anne Greenough, Eneida Torres, M. A. Verboon-Maciolek, Barbara B. Warner, Grace Rebekah, Floris Groenendaal, Shelley Drummond, Jian Huang, Harry J McArdle, Stellan Håkansson, Aloka L. Patel, Karen C. Young, Joppe Nijman, Helen E. Hayes, Shalini Ramachandran, Janet E Cade, Mark S. Thomas, Neil Marlow, Sandy Calvert, Darren C. Greenwood, Nigel Simpson, Suresh R. Devasahayam, Kalyani Kareti, Janet L. Engstrom, Mikko Hallman

Publikováno v: Neonatology. 107:372-383

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::554d01c0f72be1cf784d330a50e75577
https://doi.org/10.1159/000381158

One oxygen breath shortened the time to return of spontaneous circulation in severely asphyxiated piglets

Autor: Doris Cunha-Goncalves, Valeria Perez-de-Sa, Rikard Linner

Publikováno v: Acta paediatrica (Oslo, Norway : 1992). 106(10)

Asphyxiated neonates should be resuscitated with air, but it remains unclear if oxygen supplementation is needed in ineffectively ventilated newborn infants. We studied the return of spontaneous circulation (ROSC) with oxygen or air in an experimenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6f5db250335a735ab34fa9b25586b1
https://pubmed.ncbi.nlm.nih.gov/28876484