Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rikard G. Fred"'
Autor:
Rikard G. Fred, Julie Steen Pedersen, Jonatan J. Thompson, Julie Lee, Pascal N. Timshel, Stefan Stender, Marte Opseth Rygg, Lise Lotte Gluud, Viggo Bjerregaard Kristiansen, Flemming Bendtsen, Torben Hansen, Tune H. Pers
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The aim of this study is to characterize cell type-specific transcriptional signatures in non-alcoholic steatohepatitis (NASH) to improve our understanding of the disease. We performed single-cell RNA sequencing on liver biopsies from 10 pat
Externí odkaz:
https://doaj.org/article/fc2af34fca4b4792bd3f12cb3c30709a
Publikováno v:
Upsala Journal of Medical Sciences, Vol 122, Iss 3, Pp 149-159 (2017)
Background: Enhanced IAPP production may contribute to islet amyloid formation in type 2 diabetes. The objective of this study was to determine the effects of the saturated fatty acid palmitate on IAPP levels in human β-cells. Methods: EndoC-βH1 ce
Externí odkaz:
https://doaj.org/article/751f7d8d553644e18cb9885e22949afe
Publikováno v:
Heliyon, Vol 2, Iss 9 (2016)
Objectives: Insulin expression is highly controlled on the posttranscriptional level. The RNA binding proteins (RBPs) responsible for this result are still largely unknown. Methods and results: To identify RBPs that bind to insulin mRNA we performed
Externí odkaz:
https://doaj.org/article/faf8da48304f4e46a66e39c8574ae62b
Publikováno v:
Upsala Journal of Medical Sciences, Vol 122, Iss 3, Pp 149-159 (2017)
Upsala Journal of Medical Sciences
Upsala Journal of Medical Sciences
Background: Enhanced IAPP production may contribute to islet amyloid formation in type 2 diabetes. The objective of this study was to determine the effects of the saturated fatty acid palmitate on IAPP levels in human β-cells. Methods: EndoC-βH1 ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67e1ce25dc05a9689d648487fe532f1
https://doaj.org/article/751f7d8d553644e18cb9885e22949afe
https://doaj.org/article/751f7d8d553644e18cb9885e22949afe
Autor:
Rikard G. Fred, Andreas Ejdesjö, Ulf J. Eriksson, Peter P. Nawroth, Thomas Fleming, Sebastian Brings
Publikováno v:
Reproductive Toxicology. 62:62-70
The receptor for Advanced Glycation End products (RAGE) is implicated in the pathogenesis of diabetic complications, but its importance in diabetic embryopathy is unclear. We therefore investigated the role of RAGE in diabetic embryopathy using strep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8c6c63df557513a97d4f25669f28de
https://doi.org/10.1016/j.reprotox.2016.04.015
https://doi.org/10.1016/j.reprotox.2016.04.015
Autor:
Jens Hjerling-Leffler, Rikard G. Fred, Mia Abels, Anders Lindqvist, Rashmi B. Prasad, Liliya Shcherbina, Leif Groop, Jan Hedenbro, J A Martínez-Lopéz, M G Miskelly, Nils Wierup, B J Nergard
Publikováno v:
Molecular and Cellular Endocrinology. 511:110835
It is not known how ghrelin affects insulin secretion in human islets from patients with type 2 diabetes (T2D) or whether islet ghrelin expression or circulating ghrelin levels are altered in T2D. Here we sought out to identify the effect of ghrelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d1423084bfb0cccfc607d51c09830a
https://doi.org/10.1016/j.mce.2020.110835
https://doi.org/10.1016/j.mce.2020.110835
Publikováno v:
Clinical Science. 128:17-28
Low-density lipoprotein receptor-related protein 1 (LRP1) is an endocytic and multi-functional type I cell surface membrane protein, which is known to be phosphorylated by the activated platelet-derived growth factor receptor (PDGFR). The tyrosine ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea95878f4cb0c8aa080379be8b7fde95
https://doi.org/10.1042/cs20130560
https://doi.org/10.1042/cs20130560
Autor:
Lena Kask, Wenny Poon, Valeriya Lyssenko, Maria Sörhede-Winzell, Emma Ahlqvist, Rikard G. Fred, Ramasri Sathanoori, Ola Hansson, Hedvig Bennet, Claes B. Wollheim, Anders Tengholm, Leif Groop, Andreas Lindqvist, Marloes Dekker-Nitert, Oleg Dyachok, Vini Nagaraj, Mia Abels, Michael J. Kuhar, João Fadista, Matteo Riva, Erik Renström, Bo Ahrén, Liliya Shcherbina, Malin Fex, Nils Wierup
Publikováno v:
Diabetologia; 59(9), pp 1928-1937 (2016)
Aims/hypothesis: Insufficient insulin release and hyperglucagonaemia are culprits in type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART, encoded by Cartpt) affects islet hormone secretion and beta cell survival in vitro in rats, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c22cbb4b31308ca10758f2c1ab1781
https://lup.lub.lu.se/record/9aa0a0ed-e63e-4197-9edc-0dff545938ae
https://lup.lub.lu.se/record/9aa0a0ed-e63e-4197-9edc-0dff545938ae
Autor:
Elena N. Kozlova, Rikard G. Fred, K.T. Turpaev, Svitlana Vasylovska, Phillippe Ravassard, Anongnad Ngamjariyawat, Nils Welsh
Publikováno v:
Journal of Stem Cell Research & Therapy. 6
We have recently observed that co-culture of mouse and rat beta-cells with mouse boundary cap neural crest stem cells (bNCSCs) protected against inflammatory cytokine-induced beta-cell death, possibly via direct cadherinmediated cell-to-cell junction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d73c490c88e1c93b69f5192aee7c081
https://doi.org/10.4172/2157-7633.1000343
https://doi.org/10.4172/2157-7633.1000343
Autor:
Jing Cen, Nils Welsh, Peter Bergsten, Camilla Kappe, Raphael Scharfmann, Rikard G. Fred, Adam Ameur, Phillippe Ravassard
The aim of the present investigation was to delineate cytokine-induced signaling and death using the EndoC-beta H1 cells as a model for primary human beta-cells. The cytokines IL-1 beta and IFN-gamma induced a rapid and transient activation of NF-kap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235605ded4cf4bbc3550d0502590253c
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-264600
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-264600