Disease specific brain capillary angiopathy in schizophrenia, bipolar disorder, and Alzheimer's disease

Autor: Shinobu Hirai, Atsuhiro Sakuma, Yasuto Kunii, Hiroko Shimbo, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka, Hirooki Yabe, Rika Kojima, Erika Seki, Nobutaka Arai, Takashi Komori, Haruo Okado

Publikováno v: Journal of Psychiatric Research. 163:74-79

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d98a99f01a8e38ae112c9005db7db46
https://doi.org/10.1016/j.jpsychires.2023.04.011

S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling

Autor: Hitoshi Okamura, Axel Imhof, Jiejun Shi, Kenichiro Kinouchi, Marlene Cervantes, Kakeru Ito, Carolina Magdalen Greco, Rika Kojima, Pierre Baldi, Jean-Michel Fustin, Kevin B. Koronowski, Paolo Sassone-Corsi, Jonathan Gaucher, Wei Li, Suman Ranjit, Nicholas Ceglia, Ignasi Forné, Muntaha Samad, Enrico Gratton

Publikováno v: Science advances, vol 6, iss 51
Science Advances
Greco, C M, Cervantes, M, Fustin, J-M, Ito, K, Ceglia, N, Samad, M, Shi, J, Koronowski, K B, Forne, I, Ranjit, S, Gaucher, J, Kinouchi, K, Kojima, R, Gratton, E, Li, W, Baldi, P, Imhof, A, Okamura, H & Sassone-Corsi, P 2020, ' S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling ', Science Advances, vol. 6, no. 51, eabc5629 . https://doi.org/10.1126/sciadv.abc5629

The S-adenosylhomocysteine (SAH) hydrolyzing enzyme AHCY functionally links the circadian clock to methionine metabolism.
Circadian gene expression driven by transcription activators CLOCK and BMAL1 is intimately associated with dynamic chromati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06617683577f1e46dfddf63fd6e3fc7
https://escholarship.org/uc/item/89z9z74j

Methylation deficiency disrupts biological rhythms from bacteria to humans

Autor: Hitoshi Okamura, Jean-Michel Fustin, David Whitmore, Ellen Grünewald, Ryoichiro Kageyama, Maria Luísa Jabbur, Stephanie Tammam, Samantha J. Cargill, Marijke Versteven, Carl Hirschie Johnson, Melisa L. Lamberti, Christin Rakers, Kumiko Yoshioka-Kobayashi, P. Lynne Howell, Gerben van Ooijen, Diego A. Golombek, Takuya Matsuo, Rika Kojima, Ralf Stanewsky, Kensuke Kaneko, Kazuki Fukumoto, Shiqi Ye, Hideaki Kakeya, Yao Xu, Mayu Yamano, T. Katherine Tamai

Publikováno v: Fustin, J-M, Ye, S, Rakers, C, Kaneko, K, Fukumoto, K, Yamano, M, Versteven, M, Grünewald, E, Cargill, S J, Tamai, T K, Xu, Y, Jabbur, M L, Kojima, R, Lamberti, M L, Yoshioka-Kobayashi, K, Whitmore, D, Tammam, S, Howell, P L, Kageyama, R, Matsuo, T, Stanewsky, R, Golombek, D A, Johnson, C H, Kakeya, H, Ooijen, G V & Okamura, H 2020, ' Methylation deficiency disrupts biological rhythms from bacteria to humans ', Communications Biology, vol. 3, no. 1, 211 . https://doi.org/10.1038/s42003-020-0942-0
Communications Biology
Fustin, J-M, Ye, S, Rakers, C, Kaneko, K, Fukumoto, K, Yamano, M, Versteven, M, Grunewald, E, Cargill, S, Tamai, T K, Xu, Y, Jabbur, M L, Kojima, R, Lamberti, M L, Yoshioka Kobayashi, K, Whitmore, D, Tammam, S, Howell, P L, Kageyama, R, Matsuo, T, Stanewsky, R, Golombek, D A, Johnson, C H, Kakeya, H, Van Ooijen, G & Okamura, H 2020, ' Methylation deficiency disrupts biological rhythms from bacteria to humans ', Communications biology, vol. 3, no. 1, 211 . https://doi.org/10.1038/s42003-020-0942-0
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)

The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d6e5be01b1272356d531f73855b32e
https://doi.org/10.1038/s42003-020-0942-0

The methyl cycle is a conserved regulator of biological clocks

Autor: Marijke Versteven, Yao Xu, Maria Luísa Jabbur, Hitoshi Okamura, Jean-Michel Fustin, T. Katherine Tamai, Ralf Stanewsky, Diego A. Golombek, Melisa L. Lamberti, David Whitmore, Ryoichiro Kageyama, Shiqi Ye, Gerben van Ooijen, Rika Kojima, Christin Rakers, Kumiko Yoshioka-Kobayashi, Takuya Matsuo, Samantha J. Cargill, Carl Hirschie Johnson

The methyl cycle is a universally conserved metabolic pathway operating in prokaryotes and eukaryotes. In this pathway, the amino acid methionine is used to synthesize S-adenosylmethionine, the methyl donor co-substrate in the methylation of nucleic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548e4f2bc5d7e293e06b3bd602fdb1c6

Correction to: Comparison of glycyrrhizin content in 25 major kinds of Kampo extracts containing Glycyrrhizae Radix used clinically in Japan

Autor: Takashi Hakamatsuka, Shinsuke Hisaka, Kumiko Nagata, Masato Homma, Momoka Tada, Sayaka Masada, Mitsuhiko Nose, Rika Kojima

Publikováno v: Journal of Natural Medicines

Glycyrrhizae Radix is the most frequently used crude drug in Japan and is prescribed in Kampo medicine for the treatment of a wide range of diseases. The major active ingredient of Glycyrrhizae Radix, glycyrrhizin (GL), has been shown to possess vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24259306363a67df30c25db9c903b78
http://europepmc.org/articles/PMC5860082