Reconstituted high density lipoprotein enriched with the polyene antibiotic amphotericin B

Autor: Michael N. Oda, Peter L. Hargreaves, Jennifer A. Beckstead, Katherine A. Redmond, Rik van Antwerpen, Robert O. Ryan

Publikováno v: Journal of Lipid Research, Vol 47, Iss 2, Pp 260-267 (2006)

The polyene antibiotic amphotericin B (AMB) is an effective antifungal agent whose therapeutic potential is limited by poor aqueous solubility and toxicity toward host tissues. Addition of apolipoprotein A-I to a multilamellar phospholipid vesicle di

Externí odkaz: https://doaj.org/article/d79466102b654791adb6b9d3c1950325

Structural heterogeneity of apoB-containing serum lipoproteins visualized using cryo-electron microscopy

Autor: Rik van Antwerpen, Michael La Belle, Edita Navratilova, Ronald M. Krauss

Publikováno v: Journal of Lipid Research, Vol 40, Iss 10, Pp 1827-1836 (1999)

Cryo-electron microscopy was used to analyze the structure of lipoprotein particles in density gradient subfractions of human very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), and low density lipoprotein (LDL). Lipoproteins

Externí odkaz: https://doaj.org/article/f5821b9b499c4e838d981100a16b2192

Altered lipoprotein subclass distribution and PAF-AH activity in subjects with generalized aggressive periodontitis

Autor: John G. Tew, Rik van Antwerpen, Suzanne E. Barbour, Harvey A. Schenkein, Miguel L. Rufail

Publikováno v: Journal of Lipid Research, Vol 46, Iss 12, Pp 2752-2760 (2005)

In this study, we examined whether the documented increase of plasma triglycerides in patients with generalized aggressive periodontitis (GAgP) is associated with changes in lipoprotein subclass distribution and/or LDL-associated platelet-activating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ec5af34d5e98806cc048cca0cbe20f
https://doi.org/10.1194/jlr.m500389-jlr200

Preferred orientations of LDL in vitreous ice indicate a discoid shape of the lipoprotein particle

Autor: Rik van Antwerpen

Publikováno v: Archives of Biochemistry and Biophysics. 432:122-127

The structure of the human low-density lipoprotein (LDL) was analyzed in vitreous ice using cryo-electron microscopy (cryo-EM). In relatively thick cryo-EM preparations, random orientation of LDL particles produced various types of projections on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a35393b0f73d901d48bc88e449a388
https://doi.org/10.1016/j.abb.2004.08.031

The crayfish plasma clotting protein: A vitellogenin-related protein responsible for clot formation in crustacean blood

Autor: Rik van Antwerpen, Martin Hall, Ruigong Wang, Kenneth Söderhäll, Lars Sottrup-Jensen

Publikováno v: Hall, M, Wang, R, van Antwerpen, R, Sottrup-Jensen, L & Söderhäll, K 1999, ' The crayfish plasma clotting protein: A vitellogenin-related protein responsible for clot formation in crustacean blood ', Proceedings of the National Academy of Sciences of the United States of America, vol. 96, pp. 1965-1970 .
Hall, M, Wang, R, van Antwerpen, R, Sottrup-Jensen, L & Soederhaell, K 1999, ' The crayfish plasma clotting protein : A vitellogenin-related protein responsible for clot formation in crustacean blood ' Proceedings of the National Academy of Sciences of the United States of America, bind 96, s. 1965-1970 .

Coagulation in crayfish blood is based on the transglutaminase-mediated crosslinking of a specific plasma clotting protein. Here we report the cloning of the subunit of this clotting protein from a crayfish hepatopancreas cDNA library. The ORF encode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c80fa71d0133d7e1293ebd2d3b39e74
https://doi.org/10.1073/pnas.96.5.1965