Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Rik K, Wierenga"'
Publikováno v:
FEBS Open Bio, Vol 14, Iss 4, Pp 655-674 (2024)
Multifunctional enzyme, type‐1 (MFE1) catalyzes the second and third step of the β‐oxidation cycle, being, respectively, the 2E‐enoyl‐CoA hydratase (ECH) reaction (N‐terminal part, crotonase fold) and the NAD+‐dependent, 3S‐hydroxyacyl
Externí odkaz:
https://doaj.org/article/333c3c615e614729a5c9efb7d149d074
Autor:
Shruthi Sridhar, Alberto Zavarise, Tiila-Riikka Kiema, Subhadra Dalwani, Tor Eriksson, Yannick Hajee, Thilak Reddy Enugala, Rik K. Wierenga, Mikael Widersten
Publikováno v:
IUCrJ, Vol 10, Iss 4, Pp 437-447 (2023)
The Fe2+-dependent E. coli enzyme FucO catalyzes the reversible interconversion of short-chain (S)-lactaldehyde and (S)-1,2-propanediol, using NADH and NAD+ as cofactors, respectively. Laboratory-directed evolution experiments have been carried out p
Externí odkaz:
https://doaj.org/article/02f505bc50b84530816ebbb6260ee660
Autor:
M. Tanvir Rahman, M. Kristian Koski, Joanna Panecka-Hofman, Werner Schmitz, Alexander J. Kastaniotis, Rebecca C. Wade, Rik K. Wierenga, J. Kalervo Hiltunen, Kaija J. Autio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mitochondrial fatty acid synthesis (mtFAS) is essential for respiratory function. MtFAS generates the octanoic acid precursor for lipoic acid synthesis, but the role of longer fatty acid products has remained unclear. The structurally well-c
Externí odkaz:
https://doaj.org/article/d16d0b2bf48f43899654c6293ec0c770
Publikováno v:
Biochemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::195dd3d0dfc67c36cfab02ea96b30776
https://doi.org/10.1021/acs.biochem.3c00133
https://doi.org/10.1021/acs.biochem.3c00133
Publikováno v:
Annual Review of Biochemistry. 92
Thiolases are CoA-dependent enzymes that catalyze the thiolytic cleavage of 3-ketoacyl-CoA, as well as its reverse reaction, which is the thioester-dependent Claisen condensation reaction. Thiolases are dimers or tetramers (dimers of dimers). All thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::567c69270ca47a5eb8a0ae5089c410d6
https://doi.org/10.1146/annurev-biochem-052521-033746
https://doi.org/10.1146/annurev-biochem-052521-033746
Autor:
Yoann Millerioux, Muriel Mazet, Guillaume Bouyssou, Stefan Allmann, Tiila-Riikka Kiema, Eloïse Bertiaux, Laetitia Fouillen, Chandan Thapa, Marc Biran, Nicolas Plazolles, Franziska Dittrich-Domergue, Aline Crouzols, Rik K Wierenga, Brice Rotureau, Patrick Moreau, Frédéric Bringaud
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007116 (2018)
De novo biosynthesis of lipids is essential for Trypanosoma brucei, a protist responsible for the sleeping sickness. Here, we demonstrate that the ketogenic carbon sources, threonine, acetate and glucose, are precursors for both fatty acid and sterol
Externí odkaz:
https://doaj.org/article/9b8c7166f68b4ddd91c300754abc93b5
Autor:
Abhinandan V, Murthy, Ramita, Sulu, Andrey, Lebedev, Antti M, Salo, Kati, Korhonen, Rajaram, Venkatesan, Hongmin, Tu, Ulrich, Bergmann, Janne, Jänis, Mikko, Laitaoja, Lloyd W, Ruddock, Johanna, Myllyharju, M Kristian, Koski, Rik K, Wierenga
Publikováno v:
The Journal of biological chemistry. 298(12)
Collagen prolyl 4-hydroxylases (C-P4H) are α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00c247cc207b5944d0b940add3af0380
https://pubmed.ncbi.nlm.nih.gov/36265586
https://pubmed.ncbi.nlm.nih.gov/36265586
Autor:
Alun W. Ashton, Neil Smith, Subhadra Dalwani, Ekaterina Biterova, Joel L. Sussman, M. Kristian Koski, Tiila Riikka Kiema, Sudarshan Murthy, Shruthi Sridhar, Ville Ratas, Lari Lehtiö, Rajaram Venkatesan, Ed Daniel, Mahbubur Rahman, Mirko M. Maksimainen, Jaime Prilusky, Rik K. Wierenga, Gabriele Cordara, Orly Dym
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
The IceBear web application for monitoring and recording the results of crystallization experiments is introduced. This software includes tools for interacting directly with the ISPyB synchrotron database: metadata from shipped crystals can be upload
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0ea95486fbf4e30db4fcf4571e9b51
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-455593
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-455593
Autor:
Subhadra Dalwani, Rajaram Venkatesan, Pierre Leprovost, André H. Juffer, Werner Schmitz, Outi Lampela, Rik K. Wierenga
Publikováno v:
Journal of structural biology 213(3), 107776 (2021). doi:10.1016/j.jsb.2021.107776
'Journal of Structural Biology ', vol: 213, pages: 107776-1-107776-14 (2021)
'Journal of Structural Biology ', vol: 213, pages: 107776-1-107776-14 (2021)
The Mycobacterium tuberculosis trifunctional enzyme (MtTFE) is an α2β2 tetrameric enzyme. The α-chain harbors the 2E-enoyl-CoA hydratase (ECH) and 3S-hydroxyacyl-CoA dehydrogenase (HAD) activities and the β-chain provides the 3-ketoacyl-CoA thiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fff8c55d09946b5dc2c5f2fcd561d0
https://bib-pubdb1.desy.de/record/465323
https://bib-pubdb1.desy.de/record/465323
Autor:
Tiila-Riikka Kiema, Chandan J. Thapa, Mikko Laitaoja, Werner Schmitz, Mirko M. Maksimainen, Toshiyuki Fukao, Juha Rouvinen, Janne Jänis, Rik K. Wierenga
Publikováno v:
Biochemical Journal. 476:307-332
The SCP2 (sterol carrier protein 2)-thiolase (type-1) functions in the vertebrate peroxisomal, bile acid synthesis pathway, converting 24-keto-THC-CoA and CoA into choloyl-CoA and propionyl-CoA. This conversion concerns the β-oxidation chain shorten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6102487efdcd5d9de671ab544caed3ba
https://doi.org/10.1042/bcj20180788
https://doi.org/10.1042/bcj20180788