Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Rik J Lories"'
Autor:
Ana Escribano-Núñez, Frederique M. F. Cornelis, Astrid De Roover, An Sermon, Frédéric Cailotto, Rik J. Lories, Silvia Monteagudo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Osteoarthritis is the most common joint disease and a global leading cause of pain and disability. Current treatment is limited to symptom relief, yet there is no disease-modifying therapy. Its multifactorial etiology includes excessive acti
Externí odkaz:
https://doaj.org/article/4f057057f8e0468d84bf190f38d38b30
Autor:
Jérémie Zappia, Qiao Tong, Renée Van der Cruyssen, Frederique M. F. Cornelis, Cécile Lambert, Tiago Pinto Coelho, Juliane Grisart, Erika Kague, Rik J. Lories, Marc Muller, Dirk Elewaut, Chrissy L. Hammond, Christelle Sanchez, Yves Henrotin
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-16 (2023)
Abstract Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis (OA), and osteomodulin (OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the sclerotic phenotype. However,
Externí odkaz:
https://doaj.org/article/ce5742b9c2b84d36af2ac8b2853ba263
Autor:
Leire Casas-Fraile, Frederique M. Cornelis, Domiziana Costamagna, Anabel Rico, Robin Duelen, Maurilio M. Sampaolesi, Adolfo López de Munain, Rik J. Lories, Amets Sáenz
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-18 (2020)
Abstract Background Limb-girdle muscular dystrophy recessive 1 calpain3-related (LGMDR1), previously known as LGMD2A, is a disease caused by mutations in the CAPN3 gene. It is characterized by progressive weakness and muscle degeneration. Frizzled re
Externí odkaz:
https://doaj.org/article/5f3946e625b847ba8cc43717179513b4
Autor:
Rik J. Lories, Silvia Monteagudo
Publikováno v:
Rheumatology and Therapy, Vol 7, Iss 2, Pp 259-270 (2020)
Abstract Osteoarthritis is the most common chronic joint disease affecting millions of people worldwide and a leading cause of pain and disability. Increasing incidence of obesity and aging of the population are two factors that suggest that the impa
Externí odkaz:
https://doaj.org/article/0e4099d81e8a48cc8ebc4493a7a9fe00
Autor:
Astrid De Roover, Ana Escribano Núñez, Frederique M.F. Cornelis, Chahrazad Cherifi, Leire Casas-Fraile, An Sermon, Frederic Cailotto, Rik J. Lories, Silvia Monteagudo
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
Osteoarthritis is the most prevalent joint disease worldwide, and it is a leading source of pain and disability. To date, this disease lacks curative treatment, as underlying molecular mechanisms remain largely unknown. The histone methyltransferase
Externí odkaz:
https://doaj.org/article/243f9866ad414a8389f23a86d7ec7000
Autor:
Robert Gurke, Annika Bendes, John Bowes, Michaela Koehm, Richard M. Twyman, Anne Barton, Dirk Elewaut, Carl Goodyear, Lisa Hahnefeld, Rainer Hillenbrand, Ewan Hunter, Mark Ibberson, Vassilios Ioannidis, Sabine Kugler, Rik J. Lories, Eduard Resch, Stefan Rüping, Klaus Scholich, Jochen M. Schwenk, James C. Waddington, Phil Whitfield, Gerd Geisslinger, Oliver FitzGerald, Frank Behrens, Stephen R. Pennington
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2387 (2022)
The definitive diagnosis and early treatment of many immune-mediated inflammatory diseases (IMIDs) is hindered by variable and overlapping clinical manifestations. Psoriatic arthritis (PsA), which develops in ~30% of people with psoriasis, is a key e
Externí odkaz:
https://doaj.org/article/8ed947e41a664f22a2b952f33211051f
Publikováno v:
Therapeutic Advances in Musculoskeletal Disease, Vol 13 (2021)
Osteoarthritis (OA) is the most common chronic joint disorder worldwide, with a high personal burden for the patients and an important socio-economic impact. Current therapies are largely limited to pain management and rehabilitation and exercise str
Externí odkaz:
https://doaj.org/article/2867a56f3072489fb5621af764b1e949
Autor:
Silvia Monteagudo, Frederique M. F. Cornelis, Carolina Aznar-Lopez, Ploi Yibmantasiri, Laura-An Guns, Peter Carmeliet, Frédéric Cailotto, Rik J. Lories
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
DOT1L is one of the few genes linked to osteoarthritis by human GWAS. Here the authors show that DOT1L-dependent histone methylation protects homeostasis of articular chondrocytes by SIRT1-dependent inhibition of canonical WNT signalling, and that in
Externí odkaz:
https://doaj.org/article/04bc89636776490eb64098d886437b56
Autor:
Greetje Vande Velde, Jennifer Poelmans, Ellen De Langhe, Amy Hillen, Jeroen Vanoirbeek, Uwe Himmelreich, Rik J. Lories
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 1, Pp 91-98 (2016)
In vivo lung micro-computed tomography (micro-CT) is being increasingly embraced in pulmonary research because it provides longitudinal information on dynamic disease processes in a field in which ex vivo assessment of experimental disease models is
Externí odkaz:
https://doaj.org/article/ef47be56f1044a5ba48e802945d6acbc
Autor:
Evelyn Houtman, Margo Tuerlings, H Eka D Suchiman, Nico Lakenberg, Frederique M F Cornelis, Hailiang Mei, Demiën Broekhuis, Rob G H H Nelissen, Rodrigo Coutinho de Almeida, Yolande F M Ramos, Rik J Lories, Luis J Cruz, Ingrid Meulenbelt
Publikováno v:
Rheumatology. OXFORD UNIV PRESS
Rheumatology
Rheumatology
Objectives To investigate whether the deiodinase inhibitor iopanoic acid (IOP) has chondroprotective properties, a mechanical stress induced model of human aged explants was used to test both repeated dosing and slow release of IOP. Methods Human ost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5de7f0edc2ce0e93b2c98cd9f2a801
https://lirias.kuleuven.be/handle/20.500.12942/696032
https://lirias.kuleuven.be/handle/20.500.12942/696032
