Zobrazeno 1 - 10
of 409
pro vyhledávání: '"Rik, Ossenkoppele"'
Autor:
Marie R. Vermeiren, Joost Somsen, Gert Luurtsema, Fransje E. Reesink, Nicolaas A. Verwey, Liesbeth Hempenius, Nelleke Tolboom, Geert Jan Biessels, J. Matthijs Biesbroek, Meike W. Vernooij, Sophie E. M. Veldhuijzen van Zanten, Harro Seelaar, Emma M. Coomans, Charlotte E. Teunissen, Afina W. Lemstra, Argonde C. van Harten, Leonie N. C. Visser, Wiesje M. van der Flier, Elsmarieke van de Giessen, Rik Ossenkoppele
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Tau-PET is a diagnostic tool with high sensitivity and specificity for discriminating Alzheimer’s disease (AD) dementia from other neurodegenerative disorders in well-controlled research environments. The role of tau-PET in real
Externí odkaz:
https://doaj.org/article/d3a59bc2cf6d4922a76611eb0bd5f947
Autor:
Anna L. Svenningsson, Diana I. Bocancea, Erik Stomrud, Anita van Loenhoud, Frederik Barkhof, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Oskar Hansson, Rik Ossenkoppele
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background In Alzheimer’s disease (AD), the associations between tau pathology and brain atrophy and cognitive decline are well established, but imperfect. We investigate whether cerebrospinal fluid (CSF) biomarkers of biological processes
Externí odkaz:
https://doaj.org/article/30afe2ef6d474f0e87dfb76fa9c6b8d9
Autor:
Lyduine E. Collij, Sophie E. Mastenbroek, Niklas Mattsson-Carlgren, Olof Strandberg, Ruben Smith, Shorena Janelidze, Sebastian Palmqvist, Rik Ossenkoppele, Oskar Hansson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Identifying concomitant Lewy body (LB) pathology through seed amplification assays (SAA) might enhance the diagnostic and prognostic work-up of Alzheimer’s disease (AD) in clinical practice and trials. This study examined whether LB pathol
Externí odkaz:
https://doaj.org/article/b424508f5d0d443ba15018c78ace4615
Autor:
Ilse Bader, Colin Groot, H. Stevie Tan, Jean-Marie A. Milongo, Jurre den Haan, Inge M. W. Verberk, Keir Yong, Julie Orellina, Shannon Campbell, David Wilson, Argonde C. van Harten, Pauline H. B. Kok, Wiesje M. van der Flier, Yolande A. L. Pijnenburg, Frederik Barkhof, Elsmarieke van de Giessen, Charlotte E. Teunissen, Femke H. Bouwman, Rik Ossenkoppele
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Background Alzheimer’s disease (AD) is a common, complex and multifactorial disease that may require screening across multiple routes of referral to enable early detection and subsequent future implementation of tailored interventions. Blo
Externí odkaz:
https://doaj.org/article/80e39a0fdb1b42279ca2d571671cea81
Autor:
Sophie E. Mastenbroek, Jacob W. Vogel, Lyduine E. Collij, Geidy E. Serrano, Cécilia Tremblay, Alexandra L. Young, Richard A. Arce, Holly A. Shill, Erika D. Driver-Dunckley, Shyamal H. Mehta, Christine M. Belden, Alireza Atri, Parichita Choudhury, Frederik Barkhof, Charles H. Adler, Rik Ossenkoppele, Thomas G. Beach, Oskar Hansson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Lewy body (LB) diseases, characterized by the aggregation of misfolded α-synuclein proteins, exhibit notable clinical heterogeneity. This may be due to variations in accumulation patterns of LB neuropathology. Here we apply a data-driven di
Externí odkaz:
https://doaj.org/article/8ead8da20952462faeaafda287e2a07f
Autor:
Lyduine E. Collij, Gill Farrar, Marissa Zwan, Elsmarieke van de Giessen, Rik Ossenkoppele, Frederik Barkhof, Annemieke J. M. Rozemuller, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Femke Bouwman
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-10 (2023)
Abstract Background Previous studies demonstrated increases in diagnostic confidence and change in patient management after amyloid-PET. However, studies investigating longitudinal outcomes over an extended period of time are limited. Therefore, we a
Externí odkaz:
https://doaj.org/article/9ccb9c1fcbc94c9aaed34a13510d738f
Autor:
Hayel Tuncel, Denise Visser, Tessa Timmers, Emma E. Wolters, Rik Ossenkoppele, Wiesje M. van der Flier, Bart N. M. van Berckel, Ronald Boellaard, Sandeep S. V. Golla
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Background Dynamic PET imaging studies provide accurate estimates of specific binding, but also measure the relative tracer delivery (R1), which is a proxy for relative cerebral blood flow (rCBF). Recently, studies suggested that R1 obtained
Externí odkaz:
https://doaj.org/article/5b92fa28a272466696c487ff5bf1f7c8
Autor:
Marie-Paule E. van Engelen, Sander C. J. Verfaillie, Annemieke Dols, Mardien L. Oudega, Ronald Boellaard, Sandeep S. V. Golla, Marijke den Hollander, Rik Ossenkoppele, Philip Scheltens, Bart N. M. van Berckel, Yolande A. L. Pijnenburg, Everard G. B. Vijverberg
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Background Behavioural symptoms and frontotemporal hypometabolism overlap between behavioural variant of frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPD), hampering diagnostic distinction. Voxel-wise comparisons of bra
Externí odkaz:
https://doaj.org/article/2e33ccec1e054043a8dbf5dff021fd33
Autor:
Vikram Venkatraghavan, Betty Tijms, Hugo Kuijf, Alberto de Luca, Esther Bron, Argonde van Harten, Lieza Exalto, Frederik Barkhof, Rik Ossenkoppele, Geert Jan Biessels, Wiesje van der Flier
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100253- (2024)
Introduction: Vascular cognitive impairment (VCI) is heterogeneous in brain atrophy patterns, clinical symptoms, and possibly in the factors affecting resilience to symptoms. The objective of this study was to investigate the heterogeneity of VCI by
Externí odkaz:
https://doaj.org/article/b3aa89989623414498591f84f45ee56f
Autor:
Willem S. Eikelboom, Ellen H. Singleton, Esther van den Berg, Casper de Boer, Michiel Coesmans, Jeannette A. Goudzwaard, Everard G. B. Vijverberg, Michel Pan, Cornalijn Gouw, Merel O. Mol, Freek Gillissen, Jay L. P. Fieldhouse, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, John C. van Swieten, Rik Ossenkoppele, Jan A. Kors, Janne M. Papma
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background Neuropsychiatric symptoms (NPS) are prevalent in the early clinical stages of Alzheimer’s disease (AD) according to proxy-based instruments. Little is known about which NPS clinicians report and whether their judgment aligns wit
Externí odkaz:
https://doaj.org/article/4d57b129f0664ccaaf7252152d89c039