The plasmablast response to SARS-CoV-2 mRNA vaccination is dominated by non-neutralizing antibodies and targets both the NTD and the RBD

Autor: Daniel C. Adelsberg, Florian Krammer, Hala Alshammary, Mahima Thapa, Zhou Jq, Reiche Ag, Jackson S. Turner, Simon, Aaron J. Schmitz, Emilia Mia Sordillo, Ahmed Sms, Ali H. Ellebedy, Fatima Amanat, Shirin Strohmeier, Bakel Hv, Nicholas Borcherding, Rijnink W, Juan Manuel Carreño, Tingting Lei, Komal Srivastava, Goran Bajic, Zafar S

Publikováno v: medRxiv

SummaryIn this study we profiled vaccine-induced polyclonal antibodies as well as plasmablast derived mAbs from individuals who received SARS-CoV-2 spike mRNA vaccine. Polyclonal antibody responses in vaccinees were robust and comparable to or exceed

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https://doi.org/10.1101/2021.03.07.21253098

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The plasmablast response to SARS-CoV-2 mRNA vaccination is dominated by non-neutralizing antibodies and targets both the NTD and the RBD.

Autor: Amanat F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Thapa M; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Lei T; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Sayed Ahmed SM; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Adelsberg DC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Carreno JM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Strohmeier S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Schmitz AJ; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Zafar S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Zhou JQ; AbCellera Biologics Inc., Vancouver, BC V5Y 0A1, Canada., Rijnink W; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Alshammary H; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Borcherding N; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Reiche AG; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Srivastava K; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; AbCellera Biologics Inc., Vancouver, BC V5Y 0A1, Canada.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA., Sordillo EM; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., van Bakel H; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Turner JS; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Bajic G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Simon V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ellebedy AH; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2021 May 01. Date of Electronic Publication: 2021 May 01.