Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia

Autor: Dietmar Rudolf Thal, Alicja Ronisz, Thomas Tousseyn, Ajeet Rijal Upadhaya, Karthikeyan Balakrishnan, Rik Vandenberghe, Mathieu Vandenbulcke, Christine A. F. von Arnim, Markus Otto, Thomas G. Beach, Johan Lilja, Kerstin Heurling, Aruna Chakrabarty, Azzam Ismail, Christopher Buckley, Adrian P. L. Smith, Sathish Kumar, Gill Farrar, Jochen Walter

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-16 (2019)

Abstract Alzheimer’s disease (AD)-related amyloid β-peptide (Aβ) pathology in the form of amyloid plaques and cerebral amyloid angiopathy (CAA) spreads in its topographical distribution, increases in quantity, and undergoes qualitative changes in

Externí odkaz: https://doaj.org/article/4744e4e5830049b6bd05ed72d413054b

Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice

Autor: Rijal Upadhaya, Ajeet, Capetillo-Zarate, Estibaliz, Kosterin, Irina, Abramowski, Dorothee, Kumar, Sathish, Yamaguchi, Haruyasu, Walter, Jochen, Fändrich, Marcus, Staufenbiel, Matthias, Thal, Dietmar Rudolf

Publikováno v: In Neurobiology of Aging November 2012 33(11):2641-2660

Correction to: Different aspects of Alzheimer's disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia

Autor: Jochen Walter, Aruna Chakrabarty, Christine A. F. von Arnim, Adrian Smith, Kerstin Heurling, Thomas G. Beach, Azzam Ismail, Mathieu Vandenbulcke, Ajeet Rijal Upadhaya, Johan Lilja, Karthikeyan Balakrishnan, Gill Farrar, Rik Vandenberghe, Sathish Kumar, Alicja Ronisz, Thomas Tousseyn, Christopher Buckley, Markus Otto, Dietmar Rudolf Thal

Publikováno v: Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-3 (2020)

Alzheimer’s disease (AD)-related amyloid β-peptide (Aβ) pathology in the form of amyloid plaques and cerebral amyloid angiopathy (CAA) spreads in its topographical distribution, increases in quantity, and undergoes qualitative changes in its comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c167b0205251e69a0379d5e5378fad7a
https://pubmed.ncbi.nlm.nih.gov/31727169

Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer's disease.

Autor: Li X; Department of Imaging and Pathology, Laboratory of Neuropathology, Leuven Brain Institute, KU-Leuven, Leuven, Belgium., Ospitalieri S; Department of Imaging and Pathology, Laboratory of Neuropathology, Leuven Brain Institute, KU-Leuven, Leuven, Belgium., Robberechts T; Department of Imaging and Pathology, Laboratory of Neuropathology, Leuven Brain Institute, KU-Leuven, Leuven, Belgium., Hofmann L; Institute of Pathology, Laboratory of Neuropathology, Ulm University, Ulm, Germany., Schmid C; Institute of Pathology, Laboratory of Neuropathology, Ulm University, Ulm, Germany., Rijal Upadhaya A; Institute of Pathology, Laboratory of Neuropathology, Ulm University, Ulm, Germany., Koper MJ; Department of Imaging and Pathology, Laboratory of Neuropathology, Leuven Brain Institute, KU-Leuven, Leuven, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, KU-Leuven (University of Leuven), Leuven Brain Institute, Leuven, Belgium.; Center for Brain and Disease Research, VIB, Leuven, Belgium., von Arnim CAF; Department of Neurology, Ulm University, Ulm, Germany.; Division of Geriatrics, University Medical Center Göttingen, Göttingen, Germany., Kumar S; Department of Neurology, University of Bonn, Bonn, Germany., Willem M; Chair of Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-University Munich, Munich, Germany., Gnoth K; Department of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology, Halle, Germany., Ramakers M; Center for Brain and Disease Research, VIB, Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU-Leuven, Leuven, Belgium., Schymkowitz J; Center for Brain and Disease Research, VIB, Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU-Leuven, Leuven, Belgium., Rousseau F; Center for Brain and Disease Research, VIB, Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU-Leuven, Leuven, Belgium., Walter J; Department of Neurology, University of Bonn, Bonn, Germany., Ronisz A; Department of Imaging and Pathology, Laboratory of Neuropathology, Leuven Brain Institute, KU-Leuven, Leuven, Belgium., Balakrishnan K; Institute of Pathology, Laboratory of Neuropathology, Ulm University, Ulm, Germany.; Department of Gene Therapy, Ulm University, Ulm, Germany., Thal DR; Department of Imaging and Pathology, Laboratory of Neuropathology, Leuven Brain Institute, KU-Leuven, Leuven, Belgium.; Institute of Pathology, Laboratory of Neuropathology, Ulm University, Ulm, Germany.; Department of Pathology, UZ-Leuven, Leuven, Belgium.

Publikováno v: Brain : a journal of neurology [Brain] 2022 Oct 21; Vol. 145 (10), pp. 3558-3570.

MOESM1 of Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia

Autor: Thal, Dietmar, Ronisz, Alicja, Tousseyn, Thomas, Ajeet Rijal Upadhaya, Karthikeyan Balakrishnan, Vandenberghe, Rik, Vandenbulcke, Mathieu, Arnim, Christine Von, Otto, Markus, Beach, Thomas, Lilja, Johan, Heurling, Kerstin, Chakrabarty, Aruna, Ismail, Azzam, Buckley, Christopher, Smith, Adrian, Sathish Kumar, Farrar, Gill, Walter, Jochen

Additional file 1: Table S1. List of antibodies and silver techniques. IHC = immunohistochemistry, WB = western blotting. Table S2. Assessment of topographical distribution of Aβ plaques (a-d), CAA (a, e), and CAA severity [80] (a, f). Tissue-block

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d110d200bb4cf094b623bdeb3cbd618