Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Riina K. Arvela"'
Autor:
Johan Unge, Alejandro Trejos, Xiongyu Wu, Mats Larhed, Per Öhrngren, Lotta Vrang, Åsa Rosenquist, Advait Arun Joshi, Magnus Persson, Hans Wallberg, Riina K. Arvela, Bertil Samuelsson
Publikováno v:
Journal of Medicinal Chemistry
In an effort to identify a new class of druglike HIV-1 protease inhibitors, four different stereopure β-hydroxy γ-lactam-containing inhibitors have been synthesized, biologically evaluated, and cocrystallized. The impact of the tether length of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e08f363ec392aa48e91c23e6a9917f
http://europepmc.org/articles/PMC3310203
http://europepmc.org/articles/PMC3310203
Autor:
Federico Corelli, Mats Larhed, Alejandro Trejos, Zeger Debyser, Claudia Mugnaini, Cristina Tintori, Myriam Witvrouw, Serena Pasquini, Maurizio Botta, Martine Michiels, Riina K Arvela, Frauke Christ
Publikováno v:
Journal of Medicinal Chemistry; Vol 51
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
A set of 4-quinolone-3-carboxylic acids bearing different substituents on the condensed benzene ring was designed and synthesized as potential HIV-1 integrase inhibitors structurally related to elvitegravir. Some of the new compounds proved to be abl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da1c4e0eed3c614b1db8e3b3d56362a
Publikováno v:
Tetrahedron. 61:9349-9355
Representative Suzuki and Heck couplings in water using ultra-low catalyst concentrations have been scaled-up using an automated batch stop-flow microwave apparatus. Our scale-up methodology shows proof of concept and is easy, fast and cheap to run.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f27284ec308e0619cac9b7b3b95c95fc
https://doi.org/10.1016/j.tet.2005.07.063
https://doi.org/10.1016/j.tet.2005.07.063
Autor:
Robert D. Singer, Patricia Granados, Michael S. Sangi, Nicholas E. Leadbeater, Riina K. Arvela, Victoria A. Williams
Publikováno v:
The Journal of Organic Chemistry. 70:161-168
We present here a reassessment of our transition-metal free Suzuki-type coupling protocol. We believe that, although the reaction can be run without the need for addition of a metal catalyst, palladium contaminants down to a level of 50 ppb found in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ad692f34dced026e50adacc7167797
https://doi.org/10.1021/jo048531j
https://doi.org/10.1021/jo048531j
Publikováno v:
Synlett. :1145-1148
We report here the rapid halide exchange in aryl halides facilitated by microwave and conventional heating using nickel(II) halides as reagents. The methodology can be used for conversion of aryl chlorides to bromides, aryl iodides to bromides and ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e83a9c24b1af506f3311543def4ca5e5
https://doi.org/10.1055/s-2003-39887
https://doi.org/10.1055/s-2003-39887
Publikováno v:
ChemInform. 39
Highly regioselective and fast Pd(0)-catalyzed internal α-arylation of ethylene glycol vinyl ether with aryl halides was shown to be possible in water without the need for any halide scavengers or ionic liquid additives. This presents, to our knowle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7eca34bc8322ba7e175f1a5288f2b78
https://doi.org/10.1002/chin.200801069
https://doi.org/10.1002/chin.200801069
Publikováno v:
The Journal of organic chemistry. 72(17)
Highly regioselective and fast Pd(0)-catalyzed internal alpha-arylation of ethylene glycol vinyl ether with aryl halides was shown to be possible in water without the need for any halide scavengers or ionic liquid additives. This presents, to our kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2334790b1f177b23e6bbab88d5aee3a
https://pubmed.ncbi.nlm.nih.gov/17658848
https://pubmed.ncbi.nlm.nih.gov/17658848
Publikováno v:
ChemInform. 37
The Suzuki reaction in water using parts per million concentrations of palladium is reported using potassium trifluoroborates as alternatives to boronic acids as substrates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9cdba46f2ea661fde124759be6865d
https://doi.org/10.1002/chin.200617092
https://doi.org/10.1002/chin.200617092
Publikováno v:
ChemInform. 36
[reaction: see text]. We present here a methodology for the Suzuki coupling of aryl chlorides with phenylboronic acid using Pd/C as a catalyst, water as a solvent, and microwave heating. We show that simultaneous cooling in conjunction with microwave
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9472d5a429fb6d5e8fa37fad931cab
https://doi.org/10.1002/chin.200542102
https://doi.org/10.1002/chin.200542102
Autor:
Michael S. Sangi, Riina K. Arvela, Victoria A. Williams, Patricia Granados, Nicholas E. Leadbeater, Robert D. Singer
Publikováno v:
ChemInform. 36
We present here a reassessment of our transition-metal free Suzuki-type coupling protocol. We believe that, although the reaction can be run without the need for addition of a metal catalyst, palladium contaminants down to a level of 50 ppb found in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4888576fa30c0074f3b6d80e127c3f32
https://doi.org/10.1002/chin.200521101
https://doi.org/10.1002/chin.200521101