Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Riikka-Liisa Uronen"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The progressive accumulation and spread of misfolded tau protein in the nervous system is the hallmark of tauopathies, progressive neurodegenerative diseases with only symptomatic treatments available. A growing body of evidence suggests that spreadi
Externí odkaz:
https://doaj.org/article/9baa0048fba840afa133bd0cf11844fa
Autor:
Maria Merezhko, Cecilia A. Brunello, Xu Yan, Helena Vihinen, Eija Jokitalo, Riikka-Liisa Uronen, Henri J. Huttunen
Publikováno v:
Cell Reports, Vol 25, Iss 8, Pp 2027-2035.e4 (2018)
Summary: Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that appear to spread throughout the brain via a cell-to-cell transmission process that includes secretion and uptake of pathological Tau, followed by templated
Externí odkaz:
https://doaj.org/article/edd5d11efc994e8eb980687d1c73f433
Publikováno v:
Bioscience Reports
Misfolded, pathological tau protein propagates from cell to cell causing neuronal degeneration in Alzheimer’s disease and other tauopathies. The molecular mechanisms of this process have remained elusive. Unconventional secretion of tau takes place
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3b50cea4e5d2625d0dee8edf8dd237
https://doi.org/10.1042/bsr20210148
https://doi.org/10.1042/bsr20210148
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
The progressive accumulation and spread of misfolded tau protein in the nervous system is the hallmark of tauopathies, progressive neurodegenerative diseases with only symptomatic treatments available. A growing body of evidence suggests that spreadi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf69483d7d15305c844df5e0d5d19b32
https://doi.org/10.3389/fnmol.2020.569818
https://doi.org/10.3389/fnmol.2020.569818
Publikováno v:
Bioscience Reports
The plasma membrane consists of a variety of discrete domains differing from the surrounding membrane in composition and properties. Selective partitioning of protein to these microdomains is essential for membrane functioning and integrity. Studying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71aa0a8930eac25428ec92924c29584
https://doi.org/10.1042/bsr20191290
https://doi.org/10.1042/bsr20191290
Autor:
Pascal S. Kaeser, Nils Brose, Riikka-Liisa Uronen, Xintong Cai, Cordelia Imig, Changliang Liu, Jeong-Seop Rhee, Lauren Kershberg, Aditi Banerjee, Karthik Balakrishnan, Fritz Benseler, Jiexin Wang, Sonja M. Wojcik, Benjamin H. Cooper, Noa Lipstein
Publikováno v:
Neuron
Dopamine controls striatal circuit function, but its transmission mechanisms are not well understood. We recently showed that dopamine secretion requires RIM, suggesting that it occurs at active zone-like sites similar to conventional synapses. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6370761d5db8b8a977e88f76b3688688
https://doi.org/10.1016/j.neuron.2021.10.028
https://doi.org/10.1016/j.neuron.2021.10.028
Autor:
Henri J. Huttunen, Riikka-Liisa Uronen
Publikováno v:
Journal of Neurology and Neuromedicine. 1:17-22
In Alzheimer’s disease (AD), loss of neurons and synapses parallels the formation of neurofibrillary tangles, protein aggregates mainly composed of hyperphosphorylated and aggregated Tau protein. Tau is mostly a cytosolic protein but can also be se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d0055978ec944cf0045c0300c31293e
https://doi.org/10.29245/2572.942x/2016/2.1022
https://doi.org/10.29245/2572.942x/2016/2.1022
Autor:
Cecilia A. Brunello, Riikka-Liisa Uronen, Eija Jokitalo, Xu Yan, Helena Vihinen, Maria Merezhko, Henri J. Huttunen
Publikováno v:
SSRN Electronic Journal.
Cerebral accumulation of Tau protein aggregates, in the form of neurofibrillary tangles, is a pathological hallmark of numerous neurodegenerative disorders including Alzheimer's disease. In these tauopathies, Tau forms inclusions that spread througho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c82363ee7bf92b229c9ffe750bbf4d9
https://doi.org/10.2139/ssrn.3188432
https://doi.org/10.2139/ssrn.3188432
Publikováno v:
Seminars in celldevelopmental biology. 99
α-synuclein and Tau are proteins prone to pathological misfolding and aggregation that are normally found in the presynaptic and axonal compartments of neurons. Misfolding initiates a homo-oligomerization and aggregation cascade culminating in cereb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55ad8aa737321c7748cbc500d3faeb0
https://pubmed.ncbi.nlm.nih.gov/29738880
https://pubmed.ncbi.nlm.nih.gov/29738880
Autor:
Riikka-Liisa Uronen, Yuki Ohsaki, Terhi Vihervaara, Vesa M. Olkkonen, Maurice Jansen, Elina Ikonen
Publikováno v:
Chemistry and Physics of Lipids; Vol 164
Chemistry and Physics of Lipids
Chemistry and Physics of Lipids
Families of oxysterol-binding protein (ORP) homologues are present in eukaryotes from yeast to man. Their hallmark feature is a characteristic ligand binding domain that, for several family members, has been shown to accommodate different oxysterols
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2c5c79ae1268f4110f1f1bebf22553