Výsledky vyhledávání - "Riikka Viitanen"

Akademický článek

High folate receptor expression in gliomas can be detected in vivo using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities

Autor: Maxwell W. G. Miner, Heidi Liljenbäck, Jenni Virta, Salli Kärnä, Riikka Viitanen, Petri Elo, Maria Gardberg, Jarmo Teuho, Piritta Saipa, Johan Rajander, Hasan Mansour A Mansour, Nathan A. Cleveland, Philip S. Low, Xiang-Guo Li, Anne Roivainen

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionNon-invasive imaging techniques such as positron emission tomography (PET) are extremely important for cancer detection and characterization especially for difficult to biopsy or extremely delicate organs such as the brain. The folate ana

Externí odkaz: https://doaj.org/article/9d40fb1ffac1438f88d17102de90bf4e

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Akademický článek

[68Ga]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice

Autor: Riikka Viitanen, Helena Virtanen, Heidi Liljenbäck, Olli Moisio, Xiang-Guo Li, Valeria Nicolini, Marine Richard, Christian Klein, Tapan Nayak, Sirpa Jalkanen, Anne Roivainen

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible adhesion molecule, which supports contact between leukocytes and inflamed endothelium. There is evidence that VAP-1 is involved in the recruitment of leukocytes to melanoma tumors. Inte

Externí odkaz: https://doaj.org/article/121cb592cb1f4212bffd2668d4f41bac

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68Ga-Citrate PET of Healthy Men: Whole-Body Biodistribution Kinetics and Radiation Dose Estimates

Autor: Sami Suilamo, Xiang-Guo Li, Petteri Lankinen, Vesa Oikonen, Tuula Tolvanen, Pauliina Luoto, Riikka Viitanen, Antti Saraste, Marko Seppänen, Laura Pirilä, Ulla Hohenthal, Anne Roivainen

Publikováno v: J Nucl Med

(68)Ga-citrate has one of the simplest chemical structures of all (68)Ga-radiopharmaceuticals, and its clinical use is justified by the proven medical applications using its isotope-labeled compound (67)Ga-citrate. To support broader application of (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9935bf907a9b415706e4451ee6f254
https://doi.org/10.2967/jnumed.122.263884

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Preclinical Evaluation of a Humanized Antibody Against Common Lymphatic Endothelial and Vascular Endothelial Receptor-1

Autor: Olli, Moisio, Jenni, Virta, Emrah, Yatkin, Heidi, Liljenbäck, Senthil, Palani, Riikka, Viitanen, Maxwell W G, Miner, Vesa, Oikonen, Tuula, Tolvanen, Danielle J, Vugts, Pekka, Taimen, Xiang-Guo, Li, Maija, Hollmén, Sirpa, Jalkanen, Anne, Roivainen

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Bexmarilimab is a new humanized monoclonal antibody against common lymphatic endothelial and vascular endothelial receptor-1 (CLEVER-1), and is in clinical trials for macrophage-guided cancer immunotherapy. In addition to cancer, CLEVER-1 is also ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e77fca4e605fc4fecaa43e88eef67a0
https://pubmed.ncbi.nlm.nih.gov/36302655

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First-in-Humans Study of 68Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1

Publikováno v: Journal of Nuclear Medicine. 62:577-583

Sialic acid-binding immunoglubulin-like lectin 9 (Siglec-9) is a ligand of vascular adhesion protein 1 (VAP-1). A gallium 68-labeled peptide of Siglec-9, 68Ga-DOTA-Siglec-9, holds promise as a novel PET tracer for imaging of inflammation. This first-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ccd5aa8ab9f55ea12cf625403880b19
https://doi.org/10.2967/jnumed.120.250696

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Role of brown and beige adipose tissues in seasonal adaptation in the raccoon dog (Nyctereutes procyonoides)

Autor: Laura Niiranen, Kari A. Mäkelä, Shivaprakash J. Mutt, Riikka Viitanen, Anna Kaisanlahti, David Vicente, Tommi Noponen, Anu Autio, Anne Roivainen, Pirjo Nuutila, Seppo Saarela, Karl-Heinz Herzig

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9623, p 9623 (2021)

Brown adipose tissue (BAT) expresses uncoupling protein-1 (UCP1), which enables energy to be exerted towards needed thermogenesis. Beige adipocytes are precursor cells interspersed among white adipose tissue (WAT) that possess similar UCP1 activity a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b7b025d972c285077b0ac862e06f5b5d
http://urn.fi/urn:nbn:fi-fe2021112356441

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The circadian gene Cryptochrome 2 influences stress-induced brain activity and depressive-like behavior in mice

Autor: Anne Roivainen, Suvi Saarnio, Marie Mennesson, Timo Partonen, Saija-Anita Callan, Natalia Kulesskaya, Ewa Sokolowska, Päivi Marjamäki, Heidi Liljenbäck, Pirjo Nuutila, Sanna Kangsep, Anu Autio, Zuzanna Misiewicz, Iiris Hovatta, Riikka Viitanen

Publikováno v: Genes, brain, and behaviorREFERENCES. 20(4)

Cryptochrome 2 (Cry2) is a core clock gene important for circadian regulation. It has also been associated with anxiety and depressive-like behaviors in mice, but the previous findings have been conflicting in terms of the direction of the effect. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2592ce16ff513e62bb5bc2a2ccc2d022
https://pubmed.ncbi.nlm.nih.gov/33070440

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Hydroxysteroid (17 beta) dehydrogenase 12 is essential for metabolic homeostasis in adult mice

Autor: Fu-Ping Zhang, Anne Roivainen, Laura Mairinoja, Heidi Liljenbäck, Hanna Heikelä, Alberto Pessia, Suvi T. Ruohonen, Vidya Velagapudi, Marion Adam, Matti Poutanen, Leena Strauss, Olli Eskola, Michael Gabriel, Riikka Viitanen

Hydroxysteroid 17-beta dehydrogenase 12 (HSD17B12) is suggested to be involved in the elongation of very long chain fatty acids. Previously, we have shown a pivotal role for the enzyme during mouse development. In the present study we generated a con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbec58506f1baddceb47056efb900e2c
http://hdl.handle.net/10138/324877

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First-in-Humans Study of

Publikováno v: Journal of Nuclear Medicine

Visual Abstract
Sialic acid–binding immunoglubulinlike lectin 9 (Siglec-9) is a ligand of vascular adhesion protein 1. A 68Ga-labeled peptide of Siglec-9, 68Ga-DOTA-Siglec-9, holds promise as a novel PET tracer for imaging of inflammation. Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c0df1e850fa18a8ee8388a9d39836ad0
https://pubmed.ncbi.nlm.nih.gov/32817143

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