A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells.

Autor: Kristiina Rajala, Bettina Lindroos, Samer M Hussein, Riikka S Lappalainen, Mari Pekkanen-Mattila, Jose Inzunza, Björn Rozell, Susanna Miettinen, Susanna Narkilahti, Erja Kerkelä, Katriina Aalto-Setälä, Timo Otonkoski, Riitta Suuronen, Outi Hovatta, Heli Skottman

Publikováno v: PLoS ONE, Vol 5, Iss 4, p e10246 (2010)

BackgroundThe growth of stem cells in in vitro conditions requires optimal balance between signals mediating cell survival, proliferation, and self-renewal. For clinical application of stem cells, the use of completely defined conditions and eliminat

Externí odkaz: https://doaj.org/article/09d81d884d8f48b8b44d6709c03d6eff

Glutamate release predicts ongoing myocardial ischemia of rat hearts

Autor: Niku Oksala, Vilma Vuohelainen, Timo Paavonen, Riikka S. Lappalainen, Zhongkai Wu, Ziyou Liu, Jyrki Tenhunen, Ari Mennander, Matti Tarkka, Susanna Narkilahti

Publikováno v: Scandinavian Journal of Clinical and Laboratory Investigation. 70:217-224

Glutamate metabolism is associated with myocardial ischemia-reperfusion, but it is not clear whether glutamate reveals ongoing ischemia (OI). We evaluated whether microdialysis would detect OI induced by coronary artery ligation in a rat cardiac tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759fe6fea0745d91fd827af50dc80bbe
https://doi.org/10.3109/00365511003663655

Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: cell survival and functional recovery

Autor: Riikka S. Lappalainen, Susanna Narkilahti, Dale Corbett, Juhani Sivenius, Anna U. Hicks, Outi Hovatta, Riitta Suuronen, Jukka Jolkkonen

Publikováno v: European Journal of Neuroscience. 29:562-574

Cortical stem cell transplantation may help replace lost brain cells after stroke and improve the functional outcome. In this study, we transplanted human embryonic stem cell (hESC)-derived neural precursor cells (hNPCs) or vehicle into the cortex of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f285f487c1641e1ac2867f6c0a4331
https://doi.org/10.1111/j.1460-9568.2008.06599.x

An antibody surface for selective neuronal cell attachment

Autor: Riikka S. Lappalainen, Sanna Auer, Riitta Suuronen, Inger Vikholm-Lundin, Heli Skottman, Susanna Narkilahti

Publikováno v: Auer, S, Lappalainen, R S, Skottman, H, Suuronen, R, Narkilahti, S & Vikholm-Lundin, I 2010, ' An antibody surface for selective neuronal cell attachment ', Journal of Neuroscience Methods, vol. 186, no. 1, pp. 72-76 . https://doi.org/10.1016/j.jneumeth.2009.11.002

An optimal surface for culturing human embryonic stem cell (hESC)-derived neuronal cells is of high interest. In this study, a specific antibody to a neural cell adhesion molecule (NCAM) was immobilised on a solid surface of polystyrene and used as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae80c5c6049b61e8f7e828bfdf54ad6
https://cris.vtt.fi/en/publications/230b5a0a-5cc5-4821-b2eb-86efe5735c23

The SPECT imaging shows the accumulation of neural progenitor cells into internal organs after systemic administration in middle cerebral artery occlusion rats

Autor: Tiina Suuronen, Outi Hovatta, Ale Närvänen, Riikka S. Lappalainen, Jukka Jolkkonen, Riitta Suuronen, Susanna Narkilahti, Timo Liimatainen, Tuulia Huhtala

Publikováno v: Neuroscience letters. 440(3)

The regenerative potential of stem cells from various sources has been under intense investigation in the experimental models of cerebral ischemia. To end up with a restorative therapeutic treatment, it is crucial to get the cell transplants to the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708dc6cba609a18b98194c17cf1f6a24
https://pubmed.ncbi.nlm.nih.gov/18572314