Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Riikka Laitinen"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract The prevalence of microplastic pollution in nature and foodstuffs is fairly well identified. However, studies of micro- or nanoplastics’ cell membrane permeation and health effects in humans are lacking. Our study focuses on examining the
Externí odkaz:
https://doaj.org/article/dabd257d3e3542ac882a31f85e1d92f1
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 171 (2021)
In this study, the amino acid arginine (ARG) and P-glycoprotein (P-gp) inhibitors verapamil hydrochloride (VER), piperine (PIP) and quercetin (QRT) were used as co-formers for co-amorphous mixtures of a Biopharmaceutics classification system (BCS) cl
Externí odkaz:
https://doaj.org/article/4120191cda5b438ba6bea98db5d9a09e
Publikováno v:
Molecules, Vol 20, Iss 12, Pp 21532-21548 (2015)
In this study, spray drying from aqueous solutions, using the surface-active agent sodium lauryl sulfate (SLS) as a solubilizer, was explored as a production method for co-amorphous simvastatin–lysine (SVS-LYS) at 1:1 molar mixtures, which previous
Externí odkaz:
https://doaj.org/article/db3c9d5d544d47f58044e3b98621e97e
Publikováno v:
Journal of Pharmaceutical Sciences. 109:2252-2261
A biopharmaceutics classification system class IV drug, hydrochlorothiazide (HCT), was combined with co-formers of L-and d-arginine (ARG) and sodium lauryl sulphate (SLS) by cryomilling in 1:1 molar ratio. Co-amorphization was observed with L- and D-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48c870a25711391e7ac81a7549e088f
https://doi.org/10.1016/j.xphs.2020.04.008
https://doi.org/10.1016/j.xphs.2020.04.008
Publikováno v:
Journal of Drug Delivery Science and Technology. 77:103843
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f15e720d16b8d8a254d635c70249d48
https://doi.org/10.1016/j.jddst.2022.103843
https://doi.org/10.1016/j.jddst.2022.103843
Autor:
Ivo Laidmäe, Kalle Kirsimäe, Jemina Vesala, Laura Viidik, Ossi Korhonen, Riikka Laitinen, Jyrki Heinämäki, Jaan Aruväli, Tuomas Ervasti, Karin Kogermann, Jarkko Ketolainen
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 158
Hot-melt extruded (HME) filaments are an essential intermediate product for the three- dimensional (3D) printing of drug delivery systems (DDSs) by the fused deposition modelling (FDM) process. The aim of this study was to design novel polymeric 3D-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7ab8928ca14bbcd9aa27c99cbe3b4c
https://pubmed.ncbi.nlm.nih.gov/33115676
https://pubmed.ncbi.nlm.nih.gov/33115676
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 129:247-256
Co-amorphous systems are an attractive alternative for amorphous solid polymer dispersions in the formulation of poorly soluble drugs. Several studies have revealed that co-amorphous formulations can enhance the dissolution properties of poorly-solub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15cfc75322df3bbfc0cd715350aa6c2
https://doi.org/10.1016/j.ejpb.2018.06.007
https://doi.org/10.1016/j.ejpb.2018.06.007
Autor:
Clare J. Strachan, Thomas Rades, Holger Grohganz, Petra A. Priemel, Korbinian Löbmann, Riikka Laitinen
Publikováno v:
International Journal of Pharmaceutics. 532:1-12
Amorphous solid dispersions (ASDs) are probably the most common and important supersaturating drug delivery systems for the formulation of poorly water-soluble compounds. These delivery systems are able to achieve and maintain a sustained drug supers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350f72a43c7b7c8892558827c9041c5d
https://doi.org/10.1016/j.ijpharm.2017.08.123
https://doi.org/10.1016/j.ijpharm.2017.08.123
Publikováno v:
International Journal of Pharmaceutics. 532:289-298
Co-amorphous drug-amino acid mixtures have shown potential for improving the solid-state stability and dissolution behavior of amorphous drugs. In previous studies, however these mixtures have been produced mainly with small-scale preparation methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c356d59de5d0f51f62af461761f3af07
https://doi.org/10.1016/j.ijpharm.2017.09.015
https://doi.org/10.1016/j.ijpharm.2017.09.015
Publikováno v:
European Journal of Pharmaceutical Sciences. 104:293-301
We evaluated the physical stability of thin polymethacrylate-drug films under three different storage conditions by X-ray powder diffraction, differential scanning calorimetry, scanning electron microscopy, polarized light microscopy, and Fourier tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37c30e7a206293c5479d6c33faa1a3b
https://doi.org/10.1016/j.ejps.2017.03.027
https://doi.org/10.1016/j.ejps.2017.03.027