Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Riikka Kärnä"'
Autor:
Sanna Pasonen-Seppänen, Genevieve Bart, Timo Kumlin, Leena Rauhala, Raija Tammi, Piia Takabe, Markku Tammi, E Kärkkäinen, Riikka Kärnä, Ashik Jawahar Deen, L. Hämäläinen
Publikováno v:
Histochemistry and Cell Biology
The rodent chloride channel regulatory proteins mCLCA2 and its porcine and human homologues pCLCA2 and hCLCA2 are expressed in keratinocytes but their localization and significance in the epidermis have remained elusive. hCLCA2 regulates cancer cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33495e94a1e5c1a9f792bab13960c422
https://doi.org/10.1007/s00418-021-01962-5
https://doi.org/10.1007/s00418-021-01962-5
Autor:
Piia Takabe, Raija Tammi, Leena Rauhala, Tiina A. Jokela, Sanna Pasonen-Seppänen, Genevieve Bart, Markku Tammi, Riikka Kärnä, Sanna Oikari
Publikováno v:
Biochemical Journal. 475:1755-1772
Extracellular nucleotides are used as signaling molecules by several cell types. In epidermis, their release is triggered by insults such as ultraviolet radiation, barrier disruption, and tissue wounding, and by specific nerve terminals firing. Incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77d3bc714da2a3325ae882bf199daaab
https://doi.org/10.1042/bcj20180054
https://doi.org/10.1042/bcj20180054
Autor:
Sanna Pasonen-Seppänen, Piia Takabe, Raija Tammi, Markku Tammi, L. Hämäläinen, E Kärkkäinen, Sanna Oikari, Leena Rauhala, Genevieve Bart, Riikka Kärnä
Publikováno v:
British Journal of Dermatology. 179:651-661
Background Hyaluronan is a large, linear glycosaminoglycan present throughout the narrow extracellular space of the vital epidermis. Increased hyaluronan metabolism takes place in epidermal hypertrophy, wound healing and cancer. Hyaluronan is produce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cb1a564f505106976360cf1f706b53
https://doi.org/10.1111/bjd.16423
https://doi.org/10.1111/bjd.16423
Publikováno v:
Matrix Biology. 63:38-54
The mesothelium is a membrane that forms the lining of several body cavities. It is composed of simple squamous mesothelial cells that secrete a glycosaminoglycan-rich lubricating fluid between inner organs. One of the most abundant glycosaminoglycan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ad23211404a6836a339fe271f11bf3
https://doi.org/10.1016/j.matbio.2016.12.007
https://doi.org/10.1016/j.matbio.2016.12.007
Autor:
Petri I. Mäkinen, Maciej Lalowski, Sanna Pasonen-Seppänen, Pia Siljander, Ashik Jawahar Deen, Uma Thanigai Arasu, Kai Härkönen, Riikka Kärnä, Kirsi Rilla, Elisa Lázaro-Ibáñez, Sanna Oikari, Sami Heikkinen, Anna-Liisa Levonen
Publikováno v:
Cellular and Molecular Life Sciences
Intercellular communication is fundamental to the survival and maintenance of all multicellular systems, whereas dysregulation of communication pathways can drive cancer progression. Extracellular vesicles (EVs) are mediators of cell-to-cell communic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b332b14193b8e567681992e758baa23
https://pubmed.ncbi.nlm.nih.gov/31820036
https://pubmed.ncbi.nlm.nih.gov/31820036
Autor:
Riikka Kärnä, Raija Tammi, Ashik Jawahar Deen, Sanna Oikari, Ilari Tyni, Katri M. Makkonen, Markku Tammi
Publikováno v:
Glycobiology. 26:710-722
UDP-N-acetylglucosamine (UDP-GlcNAc) is a glucose metabolite with pivotal functions as a key substrate for the synthesis of glycoconjugates like hyaluronan, and as a metabolic sensor that controls cell functions through O-GlcNAc modification of intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62838583adcaaacb3e5f04642057ea6d
https://doi.org/10.1093/glycob/cww019
https://doi.org/10.1093/glycob/cww019
Publikováno v:
The Journal of investigative dermatology. 139(9)
Skin is constantly exposed to UVR, the most critical risk factor for melanoma development. Hyaluronan is abundant in the epidermal extracellular matrix and may undergo degradation by UVR. It is hypothesized that an intact hyaluronan coat around the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ead944670c394b850cb95d496808e2
https://pubmed.ncbi.nlm.nih.gov/30935974
https://pubmed.ncbi.nlm.nih.gov/30935974
Autor:
Davide Vigetti, Uma Thanigai Arasu, Paraskevi Heldin, Riikka Kärnä, Kirsi Rilla, R. M. Melero-Fernandez de Mera, Ashik Jawahar Deen, Alberto Passi, Markku Tammi, Sanna Oikari
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology. 80
Vesicular trafficking of hyaluronan synthases (HAS1-3) from endoplasmic reticulum (ER) through Golgi to plasma membrane (PM), and either back to endosomes and lysosomes, or out into extracellular vesicles, is important for their activities. We studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9312c85544714db7c6cf6bb18a9e63
https://pubmed.ncbi.nlm.nih.gov/30394292
https://pubmed.ncbi.nlm.nih.gov/30394292
Autor:
Leena, Rauhala, Tiina, Jokela, Riikka, Kärnä, Geneviève, Bart, Piia, Takabe, Sanna, Oikari, Markku I, Tammi, Sanna, Pasonen-Seppänen, Raija H, Tammi
Publikováno v:
The Biochemical journal. 475(10)
Extracellular nucleotides are used as signaling molecules by several cell types. In epidermis, their release is triggered by insults such as ultraviolet radiation, barrier disruption, and tissue wounding, and by specific nerve terminals firing. Incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d7f7902e4f2896fee7893186bb0e32a
https://pubmed.ncbi.nlm.nih.gov/29626161
https://pubmed.ncbi.nlm.nih.gov/29626161
Publikováno v:
Experimental Cell Research. 337:179-191
Article
Previous studies have shown that overexpression of enzymatically active GFP-HAS induces the growth of long, slender protrusions that share many features of both filopodia and microvilli. These protrusions are dependent on continuing hyal
Previous studies have shown that overexpression of enzymatically active GFP-HAS induces the growth of long, slender protrusions that share many features of both filopodia and microvilli. These protrusions are dependent on continuing hyal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8947eb4e662f0f5b52786963ab6a23
https://doi.org/10.1016/j.yexcr.2015.06.016
https://doi.org/10.1016/j.yexcr.2015.06.016