Preventing White Adipocyte Browning during Differentiation In Vitro: The Effect of Differentiation Protocols on Metabolic and Mitochondrial Phenotypes

Autor: Elena Herbers, Mimmi Patrikoski, Anita Wagner, Riikka Jokinen, Antti Hassinen, Sini Heinonen, Susanna Miettinen, Hilkka Peltoniemi, Eija Pirinen, Kirsi H. Pietiläinen

Publikováno v: Stem Cells International, Vol 2022 (2022)

Mitochondrial dysfunction in white adipose tissue is strongly associated with obesity and its metabolic complications, which are important health challenges worldwide. Human adipose-derived stromal/stem cells (hASCs) are a promising tool to investiga

Externí odkaz: https://doaj.org/article/8c7aa1d02e884f17b59049eb89c7be62

Adipose tissue NAD+-homeostasis, sirtuins and poly(ADP-ribose) polymerases -important players in mitochondrial metabolism and metabolic health

Autor: Riikka Jokinen, Sini Pirnes-Karhu, Kirsi H. Pietiläinen, Eija Pirinen

Publikováno v: Redox Biology, Vol 12, Iss , Pp 246-263 (2017)

Obesity, a chronic state of energy overload, is characterized by adipose tissue dysfunction that is considered to be the major driver for obesity associated metabolic complications. The reasons for adipose tissue dysfunction are incompletely understo

Externí odkaz: https://doaj.org/article/8e25a400df4042c49b06886f426c1f15

Differential mitochondrial gene expression in adipose tissue following weight loss induced by diet or bariatric surgery

Autor: Arne Astrup, Riikka Jokinen, Birgitta W. van der Kolk, Mikael Rydén, Sanna Kaye, Jussi Pihlajamäki, Päivi Pajukanta, Sini Heinonen, Kirsi H. Pietiläinen, Maija Vaittinen, Daniel P. Andersson, Armand Valsesia, Wim H. M. Saris, Dominique Langin, Arthur Ko, Kirsi A. Virtanen, Maheswary Muniandy, Mirva Pääkkönen, Ellen E. Blaak, Marcus Alvarez, Ville Männistö, Zong Miao, Dorota Kaminska

Publikováno v: van der Kolk, B W, Muniandy, M, Kaminska, D, Alvarez, M, Ko, A, Miao, Z, Valsesia, A, Langin, D, Vaittinen, M, Pääkkönen, M, Jokinen, R, Kaye, S, Heinonen, S, Virtanen, K A, Andersson, D P, Männistö, V, Saris, W H, Astrup, A, Rydén, M, Blaak, E E, Pajukanta, P, Pihlajamäki, J & Pietiläinen, K H 2021, ' Differential mitochondrial gene expression in adipose tissue following weight loss induced by diet or bariatric surgery ', Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 5, pp. 1312-1324 . https://doi.org/10.1210/clinem/dgab072
The Journal of Clinical Endocrinology and Metabolism
Journal of Clinical Endocrinology & Metabolism, 106(5), 1312-1324. Oxford University Press

Context Mitochondria are essential for cellular energy homeostasis, yet their role in subcutaneous adipose tissue (SAT) during different types of weight-loss interventions remains unknown. Objective To investigate how SAT mitochondria change followin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ff2e1743ec8ce1866406204a7743e9
https://curis.ku.dk/ws/files/260552389/van_der_Kolk_et_al_Journal_of_Clinical_Endocrinology_Metabolism_2021_Vol_106_5_1312_1324.pdf

Gimap3 regulates tissue-specific mitochondrial DNA segregation.

Autor: Riikka Jokinen, Paula Marttinen, Helen Katarin Sandell, Tuula Manninen, Heli Teerenhovi, Timothy Wai, Daniella Teoli, J C Loredo-Osti, Eric A Shoubridge, Brendan J Battersby

Publikováno v: PLoS Genetics, Vol 6, Iss 10, p e1001161 (2010)

Mitochondrial DNA (mtDNA) sequence variants segregate in mutation and tissue-specific manners, but the mechanisms remain unknown. The segregation pattern of pathogenic mtDNA mutations is a major determinant of the onset and severity of disease. Using

Externí odkaz: https://doaj.org/article/8a791ce681ff425e8c8158bc237a44dd

Plasma Proteomics Analysis Reveals Dysregulation of Complement Proteins and Inflammation in Acquired Obesity-A Study on Rare BMI-Discordant Monozygotic Twin Pairs

Autor: Aila Rissanen, Alen Lovric, Navid Sahebekhtiari, Kirsi H. Pietiläinen, Sakari Joenväärä, Adil Mardinoglu, Sanna Kaye, Jaakko Kaprio, Riikka Jokinen, Mayank Saraswat, Risto Renkonen

Purpose The purpose of this study is to elucidate the effect of excess body weight and liver fat on the plasma proteome without interference from genetic variation. Experimental Design The effect of excess body weight is assessed in young, healthy mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29467e5c8ab84bc3dbeb13f67e46125
http://hdl.handle.net/10138/312945