Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Riichi TAKAHASHI"'
Autor:
Ryoji Ito, Yusuke Ohno, Yunmei Mu, Yuyo Ka, Shuko Ito, Maiko Emi-Sugie, Misa Mochizuki, Kenji Kawai, Motohito Goto, Tomoyuki Ogura, Riichi Takahashi, Akira Niwa, Tatsutoshi Nakahata, Mamoru Ito
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-7 (2024)
Abstract Human hematopoietic stem cell (HSC)-transferred humanized mice are valuable models for exploring human hematology and immunology. However, sufficient recapitulation of human hematopoiesis in mice requires large quantities of enriched human C
Externí odkaz:
https://doaj.org/article/5fb3c7fe2ac54a79a530db9b5302a07c
Autor:
Shotaro Uehara, Yuichi Iida, Miyuki Ida-Tanaka, Motohito Goto, Kenji Kawai, Masafumi Yamamoto, Yuichiro Higuchi, Satoshi Ito, Riichi Takahashi, Hidetaka Kamimura, Mamoru Ito, Hiroshi Yamazaki, Mitsuo Oshimura, Yasuhiro Kazuki, Hiroshi Suemizu
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Chimeric TK-NOG mice with a humanized liver (normal Hu-liver) are a unique animal model for predicting drug metabolism in humans. However, residual mouse hepatocytes occasionally prevent the precise evaluation of human drug metabolism. Herei
Externí odkaz:
https://doaj.org/article/1d62c1e9eb1d4e0588116996e7c1f13d
Autor:
Tomoo Eto, Hiroki Ueda, Ryoji Ito, Tsukasa Takahashi, Toshiaki Watanabe, Motohito Goto, Yusuke Sotomaru, Nobuaki Tanaka, Riichi Takahashi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Genetically modified mice are commonly used in biologic, medical, and drug discovery research, but conventional microinjection methods used for genetic modification require extensive training and practical experience. Here we present a fully
Externí odkaz:
https://doaj.org/article/6be20c5eef20463a9492fcfe4c2710ab
Autor:
Satoshi Iraha, Hung-Ya Tu, Suguru Yamasaki, Takahiro Kagawa, Motohito Goto, Riichi Takahashi, Takehito Watanabe, Sunao Sugita, Shigenobu Yonemura, Genshiro A. Sunagawa, Take Matsuyama, Momo Fujii, Atsushi Kuwahara, Akiyoshi Kishino, Naoshi Koide, Mototsugu Eiraku, Hidenobu Tanihara, Masayo Takahashi, Michiko Mandai
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 1059-1074 (2018)
Summary: Increasing demand for clinical retinal degeneration therapies featuring human ESC/iPSC-derived retinal tissue and cells warrants proof-of-concept studies. Here, we established two mouse models of end-stage retinal degeneration with immunodef
Externí odkaz:
https://doaj.org/article/fa518bf2e7cc40a39d80e76bea362d35
Publikováno v:
Experimental Animals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e75b265f2ec8f68bdb4a1d966dd6041e
https://doi.org/10.1538/expanim.23-0025
https://doi.org/10.1538/expanim.23-0025
Autor:
Riichi Takahashi, Jochen Welcker, Yuyo Ka, Kayo Tomiyama, Misa Mochizuki, Ryoji Ito, Taichi Yamamoto, Tomoyuki Ogura, Motohito Goto, Mamoru Ito, Kenji Kawai, Ikumi Katano, Eiko Nishinaka
Publikováno v:
Immunology Letters. 229:55-61
Humanized mice are widely used to study the human immune system in vivo and develop therapies for various human diseases. Human peripheral blood mononuclear cells (PBMC)-engrafted NOD/Shi-scid IL2rγnull (NOG) mice are useful models for characterizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49958c87cac112f390ed0e4a72627787
https://doi.org/10.1016/j.imlet.2020.11.011
https://doi.org/10.1016/j.imlet.2020.11.011
Autor:
Ryoji Ito, Ikumi Katano, Immanuel W.H. Kwok, Lai Guan Ng, Miyuki Ida-Tanaka, Yusuke Ohno, Yunmei Mu, Hanako Morita, Eiko Nishinaka, Chiyoko Nishime, Misa Mochizuki, Kenji Kawai, Tay Hui Chien, Zhao Yunqian, Fan Yiping, Liew Hui Hua, Teja Celhar, Jerry Kok Yen Chan, Takeshi Takahashi, Motohito Goto, Tomoyuki Ogura, Riichi Takahashi, Mamoru Ito
Publikováno v:
Cell Reports. 41:111841
Neutrophils are critical mediators during the early stages of innate inflammation in response to bacterial or fungal infections. A human hematopoietic system reconstituted in humanized mice aids in the study of human hematology and immunology. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186b4f2c55686d3db09d567e0d07d031
https://doi.org/10.1016/j.celrep.2022.111841
https://doi.org/10.1016/j.celrep.2022.111841
Autor:
Motohito Goto, Kenji Kawai, Iyo Otsuka, Riichi Takahashi, Mamoru Ito, Takeshi Takahashi, Mika Yagoto, Asami Hanazawa, Ryoji Ito, Ikumi Katano, Tomoyuki Ogura
Publikováno v:
Biochemical and Biophysical Research Communications. 516:480-485
Although Th17 cells are closely linked to cutaneous graft-versus-host-disease (GVHD) in mouse models, this association remains unclear in human GVHD. In this study, we established a novel xenogeneic cutaneous GVHD model using humanized mice. To induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b9e4e9c5612caa031362d9d6d6f12a
https://doi.org/10.1016/j.bbrc.2019.06.094
https://doi.org/10.1016/j.bbrc.2019.06.094
Autor:
Masataka Suzuki, Masato Yasui, Motohito Goto, Riichi Takahashi, Jumpei Sasabe, Sayako Chiba, Kenji Hamase, Matthew K. Waldor, Takanori Kanai, Tomohisa Sujino, Mamoru Ito, Masashi Mita, Yoichi Harada
Publikováno v:
Science Advances
Molecular chirality of amino acids is linked to bacterial recognition by mammals to modulate IgA for bacterial symbiosis.
Organisms use l-amino acids (l-aa) for most physiological processes. Unlike other organisms, bacteria chiral-convert l-aa t
Organisms use l-amino acids (l-aa) for most physiological processes. Unlike other organisms, bacteria chiral-convert l-aa t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76735450dae4971699ad0f8234d57579
http://europepmc.org/articles/PMC7929512
http://europepmc.org/articles/PMC7929512
Autor:
Masami Ueno, Kayo Tomiyama, Mariko Hamano, Yuyo Ka, Yuya Nozawa, Nobuyuki Tsuruzono, Tomoyuki Ogura, Ryoko Nozu, Akira Takakura, Riichi Takahashi
Publikováno v:
Experimental Animals
To avoid microbial contamination risk, vinyl film isolators are generally used in animal microbiome experiments involving germ-free (GF) mice and/or gnotobiotic (GB) mice. However, it can take several months to gain expertise in operating the isolato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3127ab4991e0552b85e63746df3811b
https://pubmed.ncbi.nlm.nih.gov/33239489
https://pubmed.ncbi.nlm.nih.gov/33239489