Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Riia Plihtari"'
Autor:
Katariina Öörni, Kristiina Rajamäki, Su Duy Nguyen, Katariina Lähdesmäki, Riia Plihtari, Miriam Lee-Rueckert, Petri T. Kovanen
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 2, Pp 203-214 (2015)
Atherosclerotic lesions are often hypoxic and exhibit elevated lactate concentrations and local acidification of the extracellular fluids. The acidification may be a consequence of the abundant accumulation of lipid-scavenging macrophages in the lesi
Externí odkaz:
https://doaj.org/article/aeedb5e30b3e4671b3766fce7f9a8134
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 7, Pp 1801-1809 (2010)
LDL particles that enter the arterial intima become exposed to proteolytic and lipolytic modifications. The extracellular hydrolases potentially involved in LDL modification include proteolytic enzymes, such as chymase, cathepsin S, and plasmin, and
Externí odkaz:
https://doaj.org/article/5139313bc0274484b64f94a94f560b4a
Autor:
Jani Lappalainen, Katariina Öörni, Karl E.O. Åkerman, Tommy Nordström, Petri T. Kovanen, Hannele Leinonen, Miriam Lee-Rueckert, Riia Plihtari
Publikováno v:
Atherosclerosis. 312:1-7
Background and aims In focal areas of advanced human atherosclerotic lesions, the intimal fluid is acidic. An acidic medium impairs the ABCA1-mediated cholesterol efflux from macrophages, so tending to increase their content of free cholesterol, whic
Autor:
Katariina Öörni, Kristiina Rajamäki, Mikko I. Mäyränpää, Perttu J. Lindsberg, Su Duy Nguyen, Katariina Maaninka, Riia Plihtari, Petri T. Kovanen
Publikováno v:
Atherosclerosis. 275:390-399
Background and aims: Subendothelial interaction of LDL with extracellular matrix drives atherogenesis. This interaction can be strengthened by proteolytic modification of LDL. Mast cells (MCs) are present in atherosclerotic lesions, and upon activati
Autor:
Su Duy Nguyen, Miriam Lee-Rueckert, Kristiina Rajamäki, Petri T. Kovanen, Katariina Öörni, Riia Plihtari, Katariina Lähdesmäki
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 2, Pp 203-214 (2015)
Atherosclerotic lesions are often hypoxic and exhibit elevated lactate concentrations and local acidification of the extracellular fluids. The acidification may be a consequence of the abundant accumulation of lipid-scavenging macrophages in the lesi
Publikováno v:
Atherosclerosis. 217(2)
The extracellular pH is locally decreased in advanced atherosclerotic lesions, particularly in lipid-rich areas of the lesions. Since accumulation of LDL-derived cholesterol and formation of foam cells are key processes in atherogenesis, we tested he
Autor:
Pasi Soininen, Petri T. Kovanen, Mika Ala-Korpela, Riia Plihtari, Eva Hurt-Camejo, Katariina Öörni, Katariina Lähdesmäki
Publikováno v:
Atherosclerosis. 207(2)
Objective Hydrolysis of LDL by phospholipase A 2 (PLA 2 ) generates free fatty acids (FFAs) and lysophospholipids (lysoPCs). Binding of the PLA 2 -modified LDL to proteoglycans, and their uptake by macrophages are increased. Since the extracellular p