Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Rihe Liu"'
Autor:
Mengying Hu, Ying Wang, Ligeng Xu, Sai An, Yu Tang, Xuefei Zhou, Jingjing Li, Rihe Liu, Leaf Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Activated hepatic stellate cells are associated with fibrosis and liver metastases. Here, the authors identify an endogenous role of relaxin in regulating the activation of hepatic stellate cells and report nanoparticle-mediated relaxin gene therapy
Externí odkaz:
https://doaj.org/article/6b82eb1e8cdf47688cd6f310885ad26f
Autor:
Hanyong Sun, Weiqin Yang, Yuan Tian, Xuezhen Zeng, Jingying Zhou, Myth T. S. Mok, Wenshu Tang, Yu Feng, Liangliang Xu, Anthony W. H. Chan, Joanna H. Tong, Yue-Sun Cheung, Paul B. S. Lai, Hector K. S. Wang, Shun-Wa Tsang, King-Lau Chow, Mengying Hu, Rihe Liu, Leaf Huang, Bing Yang, Pengyuan Yang, Ka-Fai To, Joseph J. Y. Sung, Grace L. H. Wong, Vincent W. S. Wong, Alfred S. L. Cheng
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men. Here the authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC path
Externí odkaz:
https://doaj.org/article/6dd5d597aab145d5bf368e0227da0aaf
Autor:
Manisit Das, Xuefei Zhou, Yun Liu, Anirban Das, Benjamin G. Vincent, Jingjing Li, Rihe Liu, Leaf Huang
Publikováno v:
Translational Oncology, Vol 13, Iss 12, Pp 100856- (2020)
The immunogenic clonal-fraction threshold in heterogeneous solid-tumor required to induce effective bystander-killing of non-immunogenic subclones is unknown. Pancreatic cancer poses crucial challenges for immune therapeutic interventions due to low
Externí odkaz:
https://doaj.org/article/8030f78e807b4cc39d063f5e83946b3e
Autor:
Wantong Song, Limei Shen, Ying Wang, Qi Liu, Tyler J. Goodwin, Jingjing Li, Olekasandra Dorosheva, Tianzhou Liu, Rihe Liu, Leaf Huang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Microsatellite-stable (MSS) colorectal cancer (CRC) has shown poor response to checkpoint blockade immunotherapy. Here, the authors show that the combination of oxaliplatin with anti-PDL1 mAb is specifically efficient in the treatment of MSS CRC.
Externí odkaz:
https://doaj.org/article/0515a6d971844b1e8f9a10f726dac7a6
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 187-198 (2018)
Aptamers are widely used in numerous biochemical, bioanalytical, and biological studies. Most aptamers are developed through an in vitro selection process called SELEX against either purified targets or living cells expressing targets of interest. We
Externí odkaz:
https://doaj.org/article/eacd7a6aeb79452bad2b6fdc1bd8d020
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43077 (2012)
Multivalency of targeting ligands provides significantly increased binding strength towards their molecular targets. Here, we report the development of a novel heptameric targeting system, with general applications, constructed by fusing a target-bin
Externí odkaz:
https://doaj.org/article/976fb743dbef4d1982efd297c74eaad1
Autor:
Xiaoyu Liu, Jingying Zhou, Haoran Wu, Shufen Chen, Lingyun Zhang, Wenshu Tang, Liang Duan, Ying Wang, Eleanor McCabe, Mengying Hu, Zhuo Yu, Hanzhuang Liu, Chung Hang Jonathan Choi, Joseph Jao-yiu Sung, Leaf Huang, Rihe Liu, Alfred Sze-lok Cheng
Publikováno v:
Molecular Therapy. 31:119-133
The local microenvironment where tumors develop can shape cancer progression and therapeutic outcome. Emerging evidence demonstrate that the efficacy of immune-checkpoint blockade (ICB) is undermined by fibrotic tumor microenvironment (TME). The majo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6053fa210c7ac27584ac1c0a87e5dbc3
https://doi.org/10.1016/j.ymthe.2022.09.012
https://doi.org/10.1016/j.ymthe.2022.09.012
Autor:
Gianpietro Dotti, Rihe Liu, Barbara Savoldo, Hongxia Li, Koichi Hirabayashi, Keliang Gao, Chuang Sun, Jingjing Li, Sarah Ahn
Tumors are inherently heterogeneous in antigen expression, and escape from immune surveillance due to antigen loss remains one of the limitations of targeted immunotherapy. Despite the clinical use of adoptive therapy with chimeric antigen receptor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4935d75d77e3e3253bf01a26e97cfcc4
https://doi.org/10.1158/2326-6066.c.6549973.v1
https://doi.org/10.1158/2326-6066.c.6549973.v1
Autor:
Gianpietro Dotti, Rihe Liu, Barbara Savoldo, Hongxia Li, Koichi Hirabayashi, Keliang Gao, Chuang Sun, Jingjing Li, Sarah Ahn
Supplementary figures 1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685f09170b953a4245fe74c56eca1ab1
https://doi.org/10.1158/2326-6066.22542544.v1
https://doi.org/10.1158/2326-6066.22542544.v1
Autor:
Limei, Shen, Jingjing, Li, Qi, Liu, Manisit, Das, Wantong, Song, Xueqiong, Zhang, Karthik, Tiruthani, Oleksandra, Dorosheva, Haiyang, Hu, Samuel K, Lai, Rihe, Liu, Leaf, Huang
Publikováno v:
Journal of Controlled Release. 343:303-313
Interactions between different cell types in the tumor microenvironment (TME) affect tumor growth. Tumor-associated fibroblasts produce C-X-C motif chemokine ligand 13 (CXCL13) which recruits B cells to the TME. B-cells in the TME differentiate into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08db792552ed6188401ab2a44bfe4467
https://doi.org/10.1016/j.jconrel.2022.01.039
https://doi.org/10.1016/j.jconrel.2022.01.039