Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Riham M. Idris"'
Autor:
Vittoria Lopez, H. J. Maximilian Schuh, Salahuddin Mirza, Victoria J. Vaaßen, Michael S. Schmidt, Katharina Sylvester, Riham M. Idris, Christian Renn, Laura Schäkel, Julie Pelletier, Jean Sévigny, Annamaria Naggi, Björn Scheffler, Sang-Yong Lee, Gerd Bendas, Christa E. Müller
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHeparins, naturally occurring glycosaminoglycans, are widely used for thrombosis prevention. Upon application as anticoagulants in cancer patients, heparins were found to possess additional antitumor activities. Ectonucleotidases have rec
Externí odkaz:
https://doaj.org/article/a4e6c471d88140e28ff18ae97091a960
Autor:
Laura Schäkel, Constanze C. Schmies, Riham M. Idris, Xihuan Luo, Sang-Yong Lee, Vittoria Lopez, Salahuddin Mirza, The Hung Vu, Julie Pelletier, Jean Sévigny, Vigneshwaran Namasivayam, Christa E. Müller
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) inhibitors have potential as novel drugs for the (immuno)therapy of cancer. They increase the extracellular concentration of immunostimulatory ATP and reduce the formation of AMP, which can
Externí odkaz:
https://doaj.org/article/903114e2b7ec421aacb756b26bca55e7
Autor:
Kenneth A. Jacobson, Mirko Scortichini, Riham M. Idris, Susanne Moschütz, Antje Keim, Veronica A. Salmaso, Clemens Dobelmann, Paola A. Oliva, Karolina Losenkova, Heikki Irjala, Samuli Vaittinen, Jouko Sandholm, Gennady G. Yegutkin, Norbert Sträter, Anna Junker, Christa E. Müller
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d1ffef5b7605e42873b5327ca2ba53d
https://doi.org/10.1096/fasebj.2022.36.s1.r3981
https://doi.org/10.1096/fasebj.2022.36.s1.r3981
Autor:
Karolina Losenkova, Riham M. Idris, Yulu Wang, Laura Schäkel, Christian Renn, Constanze C. Schmies, Georg Rolshoven, Gennady G. Yegutkin, Francesca Garofano, Christa E. Müller, Haneen Al-Hroub, Ingo G.H. Schmidt-Wolf, Herbert Zimmermann
Publikováno v:
ACS Med Chem Lett
[Image: see text] Ecto-5′-nucleotidase (CD73) catalyzes the hydrolysis of AMP to anti-inflammatory, immunosuppressive adenosine. It is expressed on vascular endothelial, epithelial, and also numerous cancer cells where it strongly contributes to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a9bf386645b298c5f684bf50b8f276
https://doi.org/10.1021/acsmedchemlett.0c00391
https://doi.org/10.1021/acsmedchemlett.0c00391
Autor:
Sanjay Bhattarai, Norbert Sträter, Georg Rolshoven, Riham M. Idris, Herbert Zimmermann, Marianne Freundlieb, Aliaa Abdelrahman, Sang-Yong Lee, Christian Renn, Jan Pippel, Emma Scaletti, Christa E. Müller, Ali El-Tayeb
Publikováno v:
Journal of Medicinal Chemistry. 63:2941-2957
CD73 inhibitors are promising drugs for the (immuno)therapy of cancer. Here, we present the synthesis, structure-activity relationships, and cocrystal structures of novel derivatives of the competitive CD73 inhibitor α,β-methylene-ADP (AOPCP) subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff664fdb753878f65638b76d65c05265
https://doi.org/10.1021/acs.jmedchem.9b01611
https://doi.org/10.1021/acs.jmedchem.9b01611