Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Riham Abou-Leisa"'
Autor:
Tamer M. A. Mohamed, Riham Abou-Leisa, Nicholas Stafford, Arfa Maqsood, Min Zi, Sukhpal Prehar, Florence Baudoin-Stanley, Xin Wang, Ludwig Neyses, Elizabeth J. Cartwright, Delvac Oceandy
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Restricting hypertrophic heart growth in response to pathologic overload is an unmet therapeutic need. Here, the authors show that blocking Ca2+signaling controlled by the transport protein PMCA4 in cardiac fibroblasts enhances secretion of a potent
Externí odkaz:
https://doaj.org/article/3181bc8460874c778601d9d69e9cba89
Autor:
Qinghui Ou, Riham Abou-Leisa, Lindsey A. McNally, Abou bakr M. Salama, Pawel Lorkiewicz, Sally Hammad, Tamer M.A. Mohamed, Bradford G. Hill, Collin Wells, Roberto Bolli
Publikováno v:
Redox Biology, Vol 46, Iss, Pp 102094-(2021)
Redox Biology
Redox Biology
Aims The coordinated gene and metabolic programs that facilitate cardiomyocyte entry and progression in the cell cycle are poorly understood. The purpose of this study was to identify the metabolic changes that influence myocyte proliferation. Method
Autor:
Riham Abou-Leisa, Abou bakr M. Salama, Pawel Lorkiewicz, Tamer M.A. Mohamed, Roberto Bolli, Qinghui Ou, Sally Hammad, Bradford G. Hill, Lindsey A. McNally, Collin Wells
Publikováno v:
Circulation Research. 129
Induction of cardiomyocyte proliferation is a promising therapeutic approach to treat heart failure. Several studies have identified metabolism as an important regulator of myocyte proliferation; however, the changes in metabolism during cardiomyocyt
Autor:
Krishna Choudhary, Reuben Thomas, Tamer M.A. Mohamed, Qinghui Ou, Lindsey A. McNally, Bradford G. Hill, Riham Abou-Leisa
Publikováno v:
Circulation Research. 127
Myocardial infarction causes irreversible loss of cardiomyocytes (CMs) and often leads to heart failure. To replace the lost cells, we identified a combination of cell-cycle regulators that induces stable cytokinesis in adult post-mitotic cells. Spec
Autor:
Javid Moslehi, Qinghui Ou, Roberto Bolli, Sharon A. George, Ayman El-Baz, Alexandre J.S. Ribeiro, Anna Gams, Guruprasad A. Giridharan, Tamer M.A. Mohamed, Riham Abou-Leisa, Xian-Liang Tang, Igor R. Efimov, Daniel J. Conklin, Jessica M Miller, Bradford G. Hill, Moustafa H. Meki, Jonathan Satin, Brooke M. Ahern
Publikováno v:
Toxicol Appl Pharmacol
The limited availability of human heart tissue and its complex cell composition are major limiting factors for reliable testing drug efficacy, toxicity and understanding mechanism. Recently, we developed a functional human and pig heart slice biomime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00af679fcbdf1146b3eb2710cc2e42e3
https://doi.org/10.1101/2020.06.12.148197
https://doi.org/10.1101/2020.06.12.148197
Autor:
Xian-Liang Tang, Riham Abou-Leisa, Moustafa H. Meki, Roberto Bolli, Ayman El-Baz, Qinghui Ou, Hamzah Juhardeen, Tamer M.A. Mohamed, Guruprasad A. Giridharan, Jessica M Miller
Publikováno v:
J Vis Exp
Many novel drugs fail in clinical studies due to cardiotoxic side effects as the currently available in vitro assays and in vivo animal models poorly predict human cardiac liabilities, posing a multi-billion-dollar burden on the pharmaceutical indust
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7720, p 7720 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 7720, p 7720 (2021)
Unlike some lower vertebrates which can completely regenerate their heart, the human heart is a terminally differentiated organ. Cardiomyocytes lost during cardiac injury and heart failure cannot be replaced due to their limited proliferative capacit
Autor:
Qinghui Ou, Kamal M. Kassem, Riham Abou-Leisa, Mitesh Solanki, Roberto Bolli, Tamer M.A. Mohamed, Xian-Liang Tang
Publikováno v:
Journal of the American College of Cardiology. 77:14
Autor:
Zoë Jacobson, Ayman Al-Baz, Steven P. Jones, Bradford G. Hill, Xian-Liang Tang, Ashok Kumar, Kathryn N. Ivey, Roberto Bolli, Guruprasad A. Giridharan, Benjamin Rood, Qinghui Ou, Tamer M.A. Mohamed, Riham Abou-Leisa, Sajedah M. Hindi, Kenneth R. Brittian
Publikováno v:
Circulation Research. 125
Rationale: Heart failure is the number one killer and drug induced cardiotoxicity is a major cause of market withdrawal. The lack of availability of culture systems for human heart tissue that is functionally and structurally viable for more than 24
Autor:
Ying-Hsi Lin, Guruprasad A. Giridharan, Riham Abou-Leisa, Zoë Jacobson, Cesare M. Terracciano, Samuel A. Watson, Timothy A. McKinsey, Tamer M.A. Mohamed, Sajedah M. Hindi, Ashok Kumar, Ayman El-Baz, Filippo Perbellini, Kenneth R. Brittian, Roberto Bolli, Xian-Liang Tang, Steven P. Jones, Bradford G. Hill, Qinghui Ou, Benjamin Rood, Kathryn N. Ivey
Publikováno v:
Circ Res
Ou, Q, Jacobson, Z, Abouleisa, R, Tang, X-L, Hindi, S, Kumar, A, Ivey, K N, Giridharan, G A, Al-Baz, A, Brittian, K, Rood, B, Lin, Y-H, Watson, S A, Perbellini, F, McKinsey, T A, Hill, B G, Jones, S P, Terracciano, C M, Bolli, R & Mohamed, T M 2019, ' A Physiological Biomimetic Culture System for Pig and Human Heart Slices ', Circulation research . https://doi.org/10.1161/CIRCRESAHA.119.314996
Ou, Q, Jacobson, Z, Abouleisa, R, Tang, X-L, Hindi, S, Kumar, A, Ivey, K N, Giridharan, G A, Al-Baz, A, Brittian, K, Rood, B, Lin, Y-H, Watson, S A, Perbellini, F, McKinsey, T A, Hill, B G, Jones, S P, Terracciano, C M, Bolli, R & Mohamed, T M 2019, ' A Physiological Biomimetic Culture System for Pig and Human Heart Slices ', Circulation research . https://doi.org/10.1161/CIRCRESAHA.119.314996
Rationale: Preclinical testing of cardiotoxicity and efficacy of novel heart failure therapies faces a major limitation: the lack of an in situ culture system that emulates the complexity of human heart tissue and maintains viability and functionalit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46cc34e033f9830568e6ca3e987b547c
https://europepmc.org/articles/PMC6715512/
https://europepmc.org/articles/PMC6715512/