Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice.

Autor: Xia Y; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Prokop S; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Department of Pathology, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Bell BM; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Gorion KM; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Croft CL; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Nasif L; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Xu G; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Riffe CJ; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Manaois AN; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Strang KH; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Quintin SS; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Paterno G; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Tansey MG; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Borchelt DR; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Golde TE; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA., Giasson BI; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. bgiasson@ufl.edu.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. bgiasson@ufl.edu.; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. bgiasson@ufl.edu.

Publikováno v: Communications biology [Commun Biol] 2022 May 12; Vol. 5 (1), pp. 446. Date of Electronic Publication: 2022 May 12.

α-Synuclein Induces Progressive Changes in Brain Microstructure and Sensory-Evoked Brain Function That Precedes Locomotor Decline.

Autor: Chu WT; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611.; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611., DeSimone JC; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611., Riffe CJ; Department of Neuroscience, University of Florida, Gainesville, Florida 32611., Liu H; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611.; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611., Chakrabarty P; Department of Neuroscience, University of Florida, Gainesville, Florida 32611., Giasson BI; Department of Neuroscience, University of Florida, Gainesville, Florida 32611., Vedam-Mai V; Department of Neurology, University of Florida, Gainesville, Florida 32611., Vaillancourt DE; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611 vcourt@ufl.edu.; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611.; Department of Neurology, University of Florida, Gainesville, Florida 32611.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Aug 19; Vol. 40 (34), pp. 6649-6659. Date of Electronic Publication: 2020 Jul 15.

Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases.

Autor: Trejo-Lopez JA; Department of Pathology, Immunology, and Laboratory Medicine.; Center for Translational Research in Neurodegenerative Disease., Sorrentino ZA; Center for Translational Research in Neurodegenerative Disease.; Department of Neuroscience., Riffe CJ; Center for Translational Research in Neurodegenerative Disease.; Department of Neuroscience., Prokop S; Department of Pathology, Immunology, and Laboratory Medicine.; Center for Translational Research in Neurodegenerative Disease.; McKnight Brain Institute.; Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida., Yachnis AT; Department of Pathology, Immunology, and Laboratory Medicine., Giasson BI; Center for Translational Research in Neurodegenerative Disease.; Department of Neuroscience.; McKnight Brain Institute.

Publikováno v: Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2020 Apr 01; Vol. 79 (4), pp. 407-418.

Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy.

Autor: Koller EJ; Department of Neuroscience, University of Florida, Gainesville, FL, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Gonzalez De La Cruz E; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Machula T; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Ibanez KR; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Lin WL; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, USA., Williams T; Department of Neuroscience, University of Florida, Gainesville, FL, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Riffe CJ; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Ryu D; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Strang KH; Department of Neuroscience, University of Florida, Gainesville, FL, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Liu X; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Janus C; Department of Neuroscience, University of Florida, Gainesville, FL, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Golde TE; Department of Neuroscience, University of Florida, Gainesville, FL, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Dickson D; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, USA., Giasson BI; Department of Neuroscience, University of Florida, Gainesville, FL, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Chakrabarty P; Department of Neuroscience, University of Florida, Gainesville, FL, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2019 Oct 01; Vol. 28 (19), pp. 3255-3269.

Phosphorylation of serine 305 in tau inhibits aggregation.

Autor: Strang KH; Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32610, USA., Sorrentino ZA; Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32610, USA., Riffe CJ; Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32610, USA., Gorion KM; Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32610, USA., Vijayaraghavan N; Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32610, USA., Golde TE; Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA., Giasson BI; Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address: bgiasson@ufl.edu.

Publikováno v: Neuroscience letters [Neurosci Lett] 2019 Jan 23; Vol. 692, pp. 187-192. Date of Electronic Publication: 2018 Nov 10.