Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Riffat Ahmed"'
Autor:
Hong Ma, Yeonmi Lee, Tomonari Hayama, Crystal Van Dyken, Nuria Marti-Gutierrez, Ying Li, Riffat Ahmed, Amy Koski, Eunju Kang, Hayley Darby, Thanasup Gonmanee, Younjung Park, Don P Wolf, Chong Jai Kim, Shoukhrat Mitalipov
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201304 (2018)
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated
Externí odkaz:
https://doaj.org/article/6c5ab600f72d44f3a5e0de216afe0c22
Autor:
Caroline A Enns, Riffat Ahmed, Jiaohong Wang, Akiko Ueno, Christal Worthen, Hidekazu Tsukamoto, An-Sheng Zhang
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60534 (2013)
Bone morphogenetic protein 6 (BMP6) is an essential cytokine for the expression of hepcidin, an iron regulatory hormone secreted predominantly by hepatocytes. Bmp6 expression is upregulated by increased iron-levels in the liver. Both hepatocytes and
Externí odkaz:
https://doaj.org/article/3474c9a6f5c04923b5db791a65437356
Autor:
Paloma Martinez-Redondo, Dongmei Ji, Taosheng Huang, Refik Kayali, David M. Lee, Karen Agaronyan, Shiyu Luo, Shoukhrat Mitalipov, Nuria Marti Gutierrez, Ying Li, Crystal Van Dyken, Diana Wu, Jeffrey T. Jensen, Hong Ma, Riffat Ahmed, Aida Platero-Luengo, Xinjian Wang, Rebecca Tippner-Hedges, David Battaglia, Dmitry Temiakov, Juan Carlos Izpisua Belmonte, Amy Koski, Jun Wu, Paula Amato, Eunju Kang, Susan B. Olson, Don P. Wolf, Cengiz Cinnioglu, Tomonari Hayama, Yeon-Mi Lee
Publikováno v:
Nature. 567:E5-E9
Change history In this Letter, there are several errors regarding the assignments of mtDNA haplotypes for a subset of egg donors from our study. These errors have not been corrected online.
Autor:
Susan B. Olson, Tailai Chen, Eunju Kang, Amy Koski, Jianhui Gong, Jingye Zhang, Crystal Van Dyken, Chong-Jai Kim, P. Barton Duell, Han Zhao, Sanjiv Kaul, Ying Gu, Stephen B. Heitner, Sacha A. Krieg, Yeon-Mi Lee, Ying Li, Sang-Wook Park, Jumi Park, Zi-Jiang Chen, Thanasup Gonmanee, Hong Ma, Riffat Ahmed, Keliang Wu, Hui Yang, Tomonari Hayama, Jin-Soo Kim, Yue Shen, David Battaglia, Dan Liang, Hayley Darby, Paula Amato, Zhenzhen Hou, Aleksei Mikhalchenko, Thomas O'Leary, David M. Lee, Diana H. Wu, Yilin Yuan, Shoukhrat Mitalipov, Nuria Marti Gutierrez
Applications of genome editing ultimately depend on DNA repair triggered by targeted double-strand breaks (DSBs). However, repair mechanisms in human cells remain poorly understood and vary across different cell types. Here we report that DSBs select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7174cca0120a731eede234f13623178
https://doi.org/10.1101/2020.06.19.162214
https://doi.org/10.1101/2020.06.19.162214
Autor:
Ying Li, Dongmei Ji, Hong Ma, Stephen B. Heitner, Riffat Ahmed, Jianhui Gong, Diana H. Wu, Eunju Kang, Daesik Kim, Dan Liang, Juan Carlos Izpisua Belmonte, Crystal Van Dyken, David Battaglia, Amy Koski, Sangtae Kim, Shoukhrat Mitalipov, Sang-Wook Park, Ying Gu, David M. Lee, Don P. Wolf, Tomonari Hayama, Nuria Marti-Gutierrez, Hayley Darby, Sanjiv Kaul, Sacha A. Krieg, Jun Wu, Paula Amato, Jin-Soo Kim, A-Reum Park, Yeon-Mi Lee, Keiichiro Suzuki, Xun Xu
Publikováno v:
Nature. 560:E10-E23
Autor:
Beth Kempton, Tomonari Hayama, Mohammed Nasser, Thanasup Gonmanee, Yeon-Mi Lee, John V. Brigande, Ying Li, Hong Ma, Riffat Ahmed, Paula Amato, Hayley Darby, Crystal Van Dyken, Trevor J. McGill, Andre Terzic, Amy Koski, Eunju Kang, Michael D. Andrews, Satsuki Yamada, Shoukhrat Mitalipov, Nuria Marti Gutierrez, Dan Liang
Publikováno v:
Biol Reprod
Heritable mitochondrial DNA (mtDNA) mutations are common, yet only a few recurring pathogenic mtDNA variants account for the majority of known familial cases in humans. Purifying selection in the female germline is thought to be responsible for the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7120e71136c4b9bddb1a2ebca247bffd
https://europepmc.org/articles/PMC7068114/
https://europepmc.org/articles/PMC7068114/
Autor:
Nuria Marti-Gutierrez, Yeon-Mi Lee, Sang-Wook Park, David Battaglia, Sangtae Kim, Don P. Wolf, Diana H. Wu, Shoukhrat Mitalipov, Tomonari Hayama, Jin-Soo Kim, Hayley Darby, Ying Gu, A. Reum Park, David M. Lee, Jun Wu, Paula Amato, Stephen B. Heitner, Eunju Kang, Daesik Kim, Juan Carlos Izpisua Belmonte, Amy Koski, Dongmei Ji, Sanjiv Kaul, Sacha A. Krieg, Ying Li, Hong Ma, Riffat Ahmed, Keiichiro Suzuki, Xun Xu, Jianhui Gong, Crystal Van Dyken
Publikováno v:
Nature. 548:413-419
Genome editing has potential for the targeted correction of germline mutations. Here we describe the correction of the heterozygous MYBPC3 mutation in human preimplantation embryos with precise CRISPR-Cas9-based targeting accuracy and high homology-d
Autor:
Manoj Hariharan, Yeon-Mi Lee, David Battaglia, Don P. Wolf, Cengiz Cinnioglu, Amy Koski, Tomonari Hayama, Joseph R. Ecker, Diana H. Wu, Paula Amato, Joseph R. Nery, Ying Li, Hong Ma, Riffat Ahmed, Rebecca Tippner-Hedges, Zhuzhu Zhang, Susan B. Olson, Ryan C. O’Neil, Shoukhrat Mitalipov, Eunju Kang, Crystal Van Dyken, Nuria Marti Gutierrez, David M. Lee, Rosa Castanon, Refik Kayali, Yupeng He
Publikováno v:
Cell Stem Cell. 20:112-119
Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed therapeutically by alternative routes for oocyte formation. Here, we describe the generation of functional human oocytes following nuclear transfer of fir
Autor:
Rebecca Tippner-Hedges, Crystal Van Dyken, David Battaglia, David M. Lee, Eunju Kang, Paloma Martinez-Redondo, Karen Agaronyan, Shiyu Luo, Refik Kayali, Jun Wu, Paula Amato, Don P. Wolf, Cengiz Cinnioglu, Tomonari Hayama, Yeon-Mi Lee, Shoukhrat Mitalipov, Nuria Marti Gutierrez, Jeffrey T. Jensen, Diana Wu, Aida Platero-Luengo, Taosheng Huang, Xinjian Wang, Dmitry Temiakov, Dongmei Ji, Juan Carlos Izpisua Belmonte, Amy Koski, Susan B. Olson, Ying Li, Hong Ma, Riffat Ahmed
Publikováno v:
Nature. 540:270-275
Maternally inherited mitochondrial (mt)DNA mutations can cause fatal or severely debilitating syndromes in children, with disease severity dependent on the specific gene mutation and the ratio of mutant to wild-type mtDNA (heteroplasmy) in each cell
Autor:
Ying Li, Hong Ma, Riffat Ahmed, Don P. Wolf, Tomonari Hayama, Cary O. Harding, Rebecca Tippner-Hedges, Yeon-Mi Lee, Andre Terzic, Taosheng Huang, Shiyu Luo, Paula Amato, Eunju Kang, Amy Koski, Diana Wu, Crystal Van Dyken, David Battaglia, David M. Lee, Shoukhrat Mitalipov, Nuria Marti Gutierrez, Jeffrey T. Jensen, Xinjian Wang, Clifford D.L. Folmes
Publikováno v:
Cell Stem Cell. 18:625-636
The genetic integrity of iPSCs is an important consideration for therapeutic application. In this study, we examine the accumulation of somatic mitochondrial genome (mtDNA) mutations in skin fibroblasts, blood, and iPSCs derived from young and elderl