Výsledky vyhledávání

17α-Ethinyl-androst-5-ene-3β, 17β-diol, a Novel Potent Oral Radioprotective Agent, Confers Radioprotection of Hematopoietic Stem and Progenitor Cells in a Granulocyte Colony-Stimulating Factor–Independent Manner

Autor: Li-Rong Yi, Renjun Peng, Cheng Zhang, Zongchao Zuo, Yuwen Cong, Limei Wang, Fan Bai, Zuyin Yu, Li Zhongtang, Ya-Jun Shan, Rifang Yang, Chao Yang

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 103:217-228

Purpose The risk of radiation exposure is considered to have increased in recent years. For convenience and simple administration, development of an effective orally administered radioprotective agent is highly desirable. The steroid 5-androstene-3β

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850fc2bfd2fca23b2d1a661a3f1e97fb
https://doi.org/10.1016/j.ijrobp.2018.08.002

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Flucrypyrim, a novel uterine relaxant, has antinociceptive and anti-inflammatory effects in vivo

Autor: Lin Guo, Yue Cong, Xingan Wu, Li Zhongtang, Xiaohui Lin, Jun-Xing Dong, Limei Wang, Yuwen Cong, Rifang Yang, Zuyin Yu

Publikováno v: Scientific Reports

Consequences of primary dsysmenorrhea (PD) can be severe. Increased prostaglandin production leads to uterine contraction and insufficient blood flow to the endometrium causing ischemia and pain symptoms. Protein tyrosine kinase/phosphatase activitie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628b60cfc36bacadb026caa119ce45ba
https://doi.org/10.1038/srep42040

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Succinate ester derivative of δ-tocopherol enhances the protective effects against 60Co γ-ray-induced hematopoietic injury through granulocyte colony-stimulating factor induction in mice

Autor: Li-Rong Yi, Limei Wang, Ya-Jun Shan, Zuyin Yu, Renjun Peng, Guo-Lin Xiong, Jun-Xing Dong, Shuang Xing, Fan Bai, Li Zhongtang, Rifang Yang, Yuwen Cong, Chao Jia

Publikováno v: Scientific Reports

α-tocopherol succinate (α-TOS), γ-tocotrienol (GT3) and δ-tocotrienol (DT3) have drawn large attention due to their efficacy as radioprotective agents. α-TOS has been shown to act superior to α-tocopherol (α-TOH) in mice by reducing lethality

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d017c84a75430fb4cad02011169a8f14

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An organophosphorus hapten used in the preparation of monoclonal antibody and as an active immunization vaccine in the detoxication of soman poisoning

Autor: Lijun Zhou, Rifang Yang, Yuxia Wang, Peiyuan Jia, Yu Zhao, Junhua Wu, Ming Yu

Publikováno v: Toxicology Letters. 187:45-51

Soman is an organophosphorus neurotoxin which inhibits the activity of acetylcholinesterase (AChE). The goal of this work was to find out whether antibodies against an organophosphorus hapten could protect mice from soman toxicity. An organophosphoru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428db7583b7f47be313f41763853d75c
https://doi.org/10.1016/j.toxlet.2009.01.029

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Synthesis of2H- and3H-labelled iptakalim hydrochloride

Autor: Bohua Zhong, Rifang Yang, Liuhong Yun, Lanfu Chen, Hai Wang, Cheng Zhang

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 47:583-590

Iptakalim hydrochloride (N-(1-methylethyl)-1,1,2-trimethyl-propylamine hydrochloride) is a promising antihypertensive drug discovered and developed by Beijing Institute of Pharmacology and Toxicology. Deuterium- and tritium-labelled compounds were de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82ee233cb0e85fc440df07a8da8f25ee
https://doi.org/10.1002/jlcr.844

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The dopamine D(3) receptor antagonist YQA14 that inhibits the expression and drug-prime reactivation of morphine-induced conditioned place preference in rats

Autor: Rongrong, Hu, Rui, Song, Rifang, Yang, Ruibin, Su, Jin, Li

Publikováno v: European journal of pharmacology. 720(1-3)

Increasing evidence suggests that the mesolimbic dopamine system plays a critical role in opioid addiction. However, there is currently no standard drug treatment for opioid addiction. Growing preclinical evidence indicates that the dopamine D(3) rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a88aa68c96bc4d5d6104bac4df0448b0
https://pubmed.ncbi.nlm.nih.gov/24436985

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