Study protocol: Whole genome sequencing Implementation in standard Diagnostics for Every cancer patient (WIDE)

Autor: Kris G. Samsom, Linda J. W. Bosch, Luuk J. Schipper, Paul Roepman, Ewart de Bruijn, Louisa R. Hoes, Immy Riethorst, Lieke Schoenmaker, Lizet E. van der Kolk, Valesca P. Retèl, Geert W. J. Frederix, Tineke E. Buffart, Jacobus J. M. van der Hoeven, Emile E. Voest, Edwin Cuppen, Kim Monkhorst, Gerrit A. Meijer

Publikováno v: BMC Medical Genomics, Vol 13, Iss 1, Pp 1-7 (2020)

Abstract Background ‘Precision oncology’ can ensure the best suitable treatment at the right time by tailoring treatment towards individual patient and comprehensive tumour characteristics. In current molecular pathology, diagnostic tests which a

Externí odkaz: https://doaj.org/article/b893dbefe1164ff4809d89051f9ba87d

Feasibility of whole-genome sequencing-based tumor diagnostics in routine pathology practice

Autor: Kris G Samsom, Luuk J Schipper, Paul Roepman, Linda JW Bosch, Ferry Lalezari, Elisabeth G Klompenhouwer, Adrianus J de Langen, Tineke E Buffart, Immy Riethorst, Lieke Schoenmaker, Daoin Schout, Vincent van der Noort, Jose G van den Berg, Ewart de Bruijn, Jacobus JM van der Hoeven, Hans van Snellenberg, Lizet E van der Kolk, Edwin Cuppen, Emile E Voest, Gerrit A Meijer, Kim Monkhorst

Publikováno v: Journal of Pathology, 258(2), 179-188. John Wiley and Sons Ltd
Samsom, K G, Schipper, L J, Roepman, P, Bosch, L J W, Lalezari, F, Klompenhouwer, E G, de Langen, A J, Buffart, T E, Riethorst, I, Schoenmaker, L, Schout, D, van der Noort, V, van den Berg, J G, de Bruijn, E, van der Hoeven, J J M, van Snellenberg, H, van der Kolk, L E, Cuppen, E, Voest, E E, Meijer, G A & Monkhorst, K 2022, ' Feasibility of whole-genome sequencing-based tumor diagnostics in routine pathology practice ', Journal of Pathology, vol. 258, no. 2, pp. 179-188 . https://doi.org/10.1002/path.5988

The current increase in number and diversity of targeted anticancer agents poses challenges to the logistics and timeliness of molecular diagnostics (MolDx), resulting in underdiagnosis and treatment. Whole-genome sequencing (WGS) may provide a susta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c6dd8cc4558422774c2363cc2462e3
http://www.scopus.com/inward/record.url?scp=85135241312&partnerID=8YFLogxK

Human intestinal fluid layer separation: The effect on colloidal structures & solubility of lipophilic compounds

Autor: Riethorst, Danny, Mitra, Amitava, Kesisoglou, Filippos, Xu, Wei, Tack, Jan, Brouwers, Joachim, Augustijns, Patrick

Publikováno v: In European Journal of Pharmaceutics and Biopharmaceutics August 2018 129:104-110

The Influence of Fed State Lipolysis Inhibition on the Intraluminal Behaviour and Absorption of Fenofibrate from a Lipid-Based Formulation

Autor: Marlies Braeckmans, Joachim Brouwers, Danny Riethorst, Cécile Servais, Jan Tack, Patrick Augustijns

Publikováno v: Pharmaceutics, Vol 14, Iss 1, p 119 (2022)

The bioavailability of lipophilic drugs may or may not be increased when administered with food due to increased solubilisation in fed state gastrointestinal (GI) fluids. The in vivo interplay between drug solubilisation, lipid phase digestion and dr

Externí odkaz: https://doaj.org/article/b6838333fb984d3bad448e65af00e919

Characterization of Human Duodenal Fluids in Fasted and Fed State Conditions

Autor: Riethorst, Danny, Mols, Raf, Duchateau, Guus, Tack, Jan, Brouwers, Joachim, Augustijns, Patrick

Publikováno v: In Journal of Pharmaceutical Sciences February 2016 105(2):673-681