Defining and characterizing neuronal senescence, 'neurescence', as G X arrested cells.

Autor: Hudson HR; Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Department of Internal Medicine Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Riessland M; Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, USA; Center for Nervous System Disorders, Stony Brook University, Stony Brook, NY, USA., Orr ME; Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Department of Internal Medicine Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Salisbury VA Medical Center, Salisbury, NC, USA. Electronic address: morr@wakehealth.edu.

Publikováno v: Trends in neurosciences [Trends Neurosci] 2024 Oct 09. Date of Electronic Publication: 2024 Oct 09.

TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons.

Autor: Kim TW; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA; Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA; Department of Interdisciplinary Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA. Electronic address: taewan79@dgist.ac.kr., Koo SY; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA; Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA; Weill Cornell Neuroscience PhD Program, New York, NY, USA., Riessland M; Department of Neurobiology and Behavior, Center for Nervous System Disorders, Stony Brook University, Stony Brook, NY 11794, USA., Chaudhry F; Tri-Institutional PhD program in Computational Biology, New York, NY, USA., Kolisnyk B; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA., Cho HS; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA; Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA., Russo MV; Gene Editing and Screening Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Saurat N; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA; Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Mehta S; Gene Editing and Screening Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Garippa R; Gene Editing and Screening Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Betel D; Division of Hematology & Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Studer L; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA; Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA. Electronic address: studerl@mskcc.org.

Publikováno v: Cell [Cell] 2024 Jul 11; Vol. 187 (14), pp. 3671-3689.e23. Date of Electronic Publication: 2024 Jun 11.

The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons.

Autor: Russo T; Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York, USA.; Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York, USA., Kolisnyk B; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, USA., B S A; Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York, USA.; Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York, USA., Plessis-Belair J; Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York, USA.; Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York, USA., Kim TW; Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.; Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA., Martin J; Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York, USA.; Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York, USA., Ni J; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, USA., Pearson JA; Medical Scientist Training Program, Stony Brook University Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA., Park EJ; Stem Cells and Regenerative Medicine, Center for Cell and Gene Therapy, Department of Molecular and Cellular Biology and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA., Sher RB; Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York, USA.; Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York, USA., Studer L; Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.; Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA., Riessland M; Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York, USA.; Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York, USA.

Publikováno v: Aging cell [Aging Cell] 2024 Apr; Vol. 23 (4), pp. e14077. Date of Electronic Publication: 2024 Feb 01.

The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons.

Autor: Russo T; Department of Neurobiology and Behavior; Stony Brook University, Stony Brook, NY 11794, USA.; Center for Nervous System Disorders; Stony Brook University, Stony Brook, NY 11794, USA., Kolisnyk B; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA., Aswathy BS; Department of Neurobiology and Behavior; Stony Brook University, Stony Brook, NY 11794, USA.; Center for Nervous System Disorders; Stony Brook University, Stony Brook, NY 11794, USA., Wan Kim T; Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA.; Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA., Martin J; Department of Neurobiology and Behavior; Stony Brook University, Stony Brook, NY 11794, USA.; Center for Nervous System Disorders; Stony Brook University, Stony Brook, NY 11794, USA., Plessis-Belair J; Department of Neurobiology and Behavior; Stony Brook University, Stony Brook, NY 11794, USA.; Center for Nervous System Disorders; Stony Brook University, Stony Brook, NY 11794, USA., Ni J; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA., Pearson JA; Medical Scientist Training Program, Stony Brook University Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Park EJ; Stem Cells and Regenerative Medicine, Center for Cell and Gene Therapy, Department of Molecular and Cellular Biology and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Sher RB; Department of Neurobiology and Behavior; Stony Brook University, Stony Brook, NY 11794, USA.; Center for Nervous System Disorders; Stony Brook University, Stony Brook, NY 11794, USA., Studer L; Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA.; Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA., Riessland M; Department of Neurobiology and Behavior; Stony Brook University, Stony Brook, NY 11794, USA.; Center for Nervous System Disorders; Stony Brook University, Stony Brook, NY 11794, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 21. Date of Electronic Publication: 2023 Jul 21.

Age-Related Midbrain Inflammation and Senescence in Parkinson's Disease.

Autor: Russo T; Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, United States.; Center for Nervous System Disorders, Stony Brook University, Stony Brook, NY, United States., Riessland M; Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, United States.; Center for Nervous System Disorders, Stony Brook University, Stony Brook, NY, United States.

Publikováno v: Frontiers in aging neuroscience [Front Aging Neurosci] 2022 Jun 02; Vol. 14, pp. 917797. Date of Electronic Publication: 2022 Jun 02 (Print Publication: 2022).