Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ries J Langley"'
Autor:
Ries J Langley, Yi Tian Ting, Fiona Clow, Paul G Young, Fiona J Radcliff, Jeong Min Choi, Richard P Sequeira, Silva Holtfreter, Heather Baker, John D Fraser
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006549 (2017)
Staphylococcus aureus is an opportunistic pathogen that produces many virulence factors. Two major families of which are the staphylococcal superantigens (SAgs) and the Staphylococcal Superantigen-Like (SSL) exoproteins. The former are immunomodulato
Externí odkaz:
https://doaj.org/article/40b9902d97ac42128986edcdb616c876
Autor:
Jinal Patel, Ries J. Langley, Petr Tomek, Bruce C. Baguley, David Barker, Euphemia Leung, Ayesha Zafar, Christopher J. Squire, Michelle van Rensburg, Lisa I. Pilkington, Jennifer A. Hollywood, Ivanhoe K. H. Leung, Nuala A. Helsby, William A. Denny, Jóhannes Reynisson
Publikováno v:
Oncology and Therapy
Cancer chemotherapy sensitizers hold the key to maximizing the potential of standard anticancer treatments. We have a long-standing interest in developing and validating inhibitors of the DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (TDP1) as ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395b729365257e39d418a57e44e4a605
https://doi.org/10.1007/s40487-021-00158-0
https://doi.org/10.1007/s40487-021-00158-0
Autor:
Man Lu, Yue Wang, Ries J. Langley, Stephen M. F. Jamieson, Kyle Tamshen, Heather D. Maynard, Jo K. Perry
Publikováno v:
Bioconjugate Chemistry. 31:1651-1660
Growth hormone (GH) is a peptide hormone that mediates actions through binding to a cell surface GH receptor (GHR). The GHR antagonist, B2036, combines an amino acid substitution at 120 that confers GHR antagonist activity, with eight additional amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bed5a13c45c01ffa4dcdfb8008a30680
https://doi.org/10.1021/acs.bioconjchem.0c00208
https://doi.org/10.1021/acs.bioconjchem.0c00208
Autor:
Jóhannes Reynisson, Ries J. Langley, Lisa I. Pilkington, David Barker, Chatchakorn Eurtivong, Nabangshu Sharma, Shaun W.P. Rees, Ryan Joseph Dixon, Ivanhoe K. H. Leung, Emily K. Paulin, Euphemia Leung
The Bacillus cereus phosphatidylcholine-specific phospholipase C (PC-PLCBc) is an enzyme that catalyses the hydrolysis of phosphatidylcholines into phosphocholine and 1,2-diacylglycerols. PC-PLCBc has found applications in both the food industry and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d32c4ce2cb1e102956aea9faa44c202
Autor:
Kyle Tamshen, Heather D. Maynard, Yue Wang, Martin Middleditch, Stephen M. F. Jamieson, Ries J. Langley, Julia K. Harms, Jo K. Perry
Publikováno v:
Biomacromolecules. 22(2)
Growth hormone (GH) has been implicated in cancer progression andis a potential target for anticancer therapy. Currently, pegvisomant is the only GH receptor (GHR) antagonist approved for clinical use. Pegvisomant is a mutated GH molecule (B2036) whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95af3b87c8110e32d1247c62ae2b518
https://pubmed.ncbi.nlm.nih.gov/33295758
https://pubmed.ncbi.nlm.nih.gov/33295758
Autor:
Yue, Wang, Ries J, Langley, Kyle, Tamshen, Stephen M, Jamieson, Man, Lu, Heather D, Maynard, Jo K, Perry
Publikováno v:
Bioconjugate chemistry. 31(6)
Growth hormone (GH) is a peptide hormone that mediates actions through binding to a cell surface GH receptor (GHR). The GHR antagonist, B2036, combines an amino acid substitution at 120 that confers GHR antagonist activity, with eight additional amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b11ea69814d539dfd53fab08857c961
https://pubmed.ncbi.nlm.nih.gov/32423203
https://pubmed.ncbi.nlm.nih.gov/32423203
Autor:
Stephen M. F. Jamieson, Yue Wang, Jo K. Perry, Ries J. Langley, Kyle Tamshen, Heather D. Maynard
Publikováno v:
Journal of the Endocrine Society
Growth hormone (GH) is a peptide hormone that mediates actions through binding to a cell surface GH receptor (GHR), activating key signalling pathways including the JAK/STAT pathway. Excess GH secretion leads to acromegaly and tumoral expression has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f400397a4551837c32741501fe446eaa
https://doi.org/10.1210/jendso/bvaa046.408
https://doi.org/10.1210/jendso/bvaa046.408
Autor:
Ivanhoe K. H. Leung, Kevin Sparrow, Emily K. Paulin, Ries J. Langley, Michelle van Rensburg, Shaun W.P. Rees, Chris Sun Xu, Lisa I. Pilkington, Euphemia Leung, Jóhannes Reynisson, David Barker
Publikováno v:
European Journal of Medicinal Chemistry. 191:112162
Phospholipases are enzymes that are involved in the hydrolysis of acyl and phosphate esters of phospholipids, generating secondary messengers that have implications in various cellular processes including proliferation, differentiation and motility.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896b0279a5cb13874977e6373c43ecaa
https://doi.org/10.1016/j.ejmech.2020.112162
https://doi.org/10.1016/j.ejmech.2020.112162
Autor:
S.J. Hermans, John D. Fraser, Edward N. Baker, Heather M. Baker, Richard P. Sequeira, Ries J. Langley
Publikováno v:
Infection and Immunity. 80:4004-4013
Staphylococcus aureus is a prevalent and significant human pathogen. Among the repertoire of virulence factors produced by this bacterium are the 14 staphylococcal superantigen-like (SSL) proteins. SSL protein 4 (SSL4) is one member of this family an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7352c8e5eb32f95c1fb79f2c7be49266
https://doi.org/10.1128/iai.00764-12
https://doi.org/10.1128/iai.00764-12
Autor:
Edward N. Baker, Ries J. Langley, Heather M. Baker, John D. Fraser, Matthew C. Chung, Bruce D. Wines
Publikováno v:
Molecular Microbiology. 66:1342-1355
Staphylococcus aureus is a major pathogen that produces a family of 14 staphylococcal superantigen-like (SSL) proteins, which are structurally similar to superantigens but do not stimulate T cells. SSL11 is one member of the family that is found in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::193da497e9ff0eadeee252fc00be6b58
https://doi.org/10.1111/j.1365-2958.2007.05989.x
https://doi.org/10.1111/j.1365-2958.2007.05989.x