Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Rienk, Offringa"'
Autor:
Aaron Rodriguez Ehrenfried, Stefan Zens, Laura Steffens, Hannes Kehm, Alina Paul, Claudia Lauenstein, Michael Volkmar, Isabel Poschke, Zibo Meng, Rienk Offringa
Publikováno v:
Bio-Protocol, Vol 14, Iss 8 (2024)
The advent of single-cell RNA sequencing (scRNAseq) has enabled in-depth gene expression analysis of several thousand cells isolated from tissues. We recently reported the application of scRNAseq toward the dissection of the tumor-infiltrating T-cell
Externí odkaz:
https://doaj.org/article/80169e7abb4d4422805f14f9da771b21
Autor:
Michael Volkmar, Elham Fakhr, Stefan Zens, Alice Bury, Rienk Offringa, Jessica Gordon, Enes Huduti, Thomas Wölfel, Catherine Wölfel
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Here, we describe the identification of two T-cell receptors (TRs) containing TRDV genes in their TRA chains, the first one in human and the second one in mouse. First, using 5’RACE on a mixed lymphocyte-tumor cell culture (MLTC), we identified TRD
Externí odkaz:
https://doaj.org/article/a94935e9201446238650f1a5f250b8d8
Autor:
Rienk Offringa, Ralf Lesche, Iris Oezen, Michael Platten, Daniel Baumann, Christiane A Opitz, Ahmed Sadik, Catherine Olesch, Frederik Cichon, Norbert Schmees, Ulrike Roehn, Florian Prinz, Detlef Stoeckigt, Katharina Sahm, Nirmeen Elmadany, Christina Kober, Julian Roewe, Lars Roese, Benjamin Bader, Mátyás Gorjánácz, Helge Gottfried Roider, Gabriele Leder, Horst Irlbacher, Julien Lefranc, Mine Oezcan-Wahlbrink, Ankita Sati Batra, Rafael Carretero, Hilmar Weinmann, Ingo V Hartung, Bertolt Kreft, Ilona Gutcher
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background The metabolism of tryptophan to kynurenines (KYN) by indoleamine-2,3-dioxygenase or tryptophan-2,3-dioxygenase is a key pathway of constitutive and adaptive tumor immune resistance. The immunosuppressive effects of KYN in the tumor microen
Externí odkaz:
https://doaj.org/article/bc1e59d7b2b148a6869f255df5b9d454
Autor:
Rienk Offringa, Catherine Olesch, Frederik Cichon, Mareike Grees, Norbert Schmees, Ulrike Roehn, Florian Prinz, Detlef Stoeckigt, Michael Erkelenz, Thi Thanh Uyen Nguyen, Ulf Boemer, Judith Günther, Marc Kunze, Kirstin Petersen, Dennis Kirchhoff
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/07ab2b5c8fd7488eb234fe061e205932
Autor:
Tamara Steinfass, Juliane Poelchen, Qian Sun, Giovanni Mastrogiulio, Daniel Novak, Marlene Vierthaler, Sandra Pardo, Aniello Federico, Laura Hüser, Thomas Hielscher, Rafael Carretero, Rienk Offringa, Peter Altevogt, Viktor Umansky, Jochen Utikal
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-6 (2023)
Abstract Melanoma is the deadliest form of skin cancer showing rising incidence over the past years. New insights into the mechanisms of melanoma progression contributed to the development of novel treatment options, such as immunotherapies. However,
Externí odkaz:
https://doaj.org/article/415acc4442a0436faeded46a1f470750
Autor:
Jessica Pinkert, Hans-Henning Boehm, Mark Trautwein, Wolf-Dietrich Doecke, Florian Wessel, Yingzi Ge, Eva Maria Gutierrez, Rafael Carretero, Christoph Freiberg, Uwe Gritzan, Merlin Luetke-Eversloh, Sven Golfier, Oliver Von Ahsen, Valentina Volpin, Antonio Sorrentino, Anchana Rathinasamy, Maria Xydia, Robert Lohmayer, Julian Sax, Ayse Nur-Menevse, Abir Hussein, Slava Stamova, Georg Beckmann, Julian Marius Glueck, Dorian Schoenfeld, Joerg Weiske, Dieter Zopf, Rienk Offringa, Bertolt Kreft, Philipp Beckhove, Joerg Willuda
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), a cell surface receptor, is expressed on normal epithelial tissue and highly expressed in cancers of high unmet medical need, such as non-small cell lung, pancreatic, and colorectal
Externí odkaz:
https://doaj.org/article/b51b522082204e19b3b78844000d71d5
Autor:
Laura Hartmann, Philipp Schröter, Wolfram Osen, Daniel Baumann, Rienk Offringa, Mahmoud Moustafa, Rainer Will, Jürgen Debus, Stephan Brons, Stefan Rieken, Stefan B. Eichmüller
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract While for photon radiation hypofractionation has been reported to induce enhanced immunomodulatory effects, little is known about the immunomodulatory potential of carbon ion radiotherapy (CIRT). We thus compared the radio-immunogenic effect
Externí odkaz:
https://doaj.org/article/922b225c3b544655b294c9222875593d
Autor:
Daniel Baumann, Rienk Offringa
Publikováno v:
Cell Stress, Vol 4, Iss 10, Pp 248-251 (2020)
The widespread application of immune-checkpoint blockade (ICB) has resulted in unprecedented response rates in patients with immunogenic cancers, such as melanoma and lung cancer. However, sub-groups of patients with these indications do not respond
Externí odkaz:
https://doaj.org/article/a3280ba5369741d1a16602bb362e5bf8
Autor:
Zibo Meng, Qingchen Yuan, Jingyuan Zhao, Bo Wang, Shoukang Li, Rienk Offringa, Xin Jin, Heshui Wu
Publikováno v:
Molecular Therapy: Oncolytics, Vol 17, Iss , Pp 460-470 (2020)
N6-methyladenosine (m6A) has an important epitranscriptomic modification that controls cancer self-renewal and cell fate. The addition of m6A to mRNA is a reversible modification. The deposition of m6A is encoded by a methyltransferase complex involv
Externí odkaz:
https://doaj.org/article/db3f374cbcf84949ae848829792192ac
Autor:
Matthias Bozza, Edward W. Green, Elisa Espinet, Alice De Roia, Corinna Klein, Vanessa Vogel, Rienk Offringa, James A. Williams, Martin Sprick, Richard P. Harbottle
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 957-968 (2020)
We describe herein non-integrating minimally sized nano-S/MAR DNA vectors, which can be used to genetically modify dividing cells in place of integrating vectors. They represent a unique genetic tool, which avoids vector-mediated damage. Previous wor
Externí odkaz:
https://doaj.org/article/c209bacd632e4cabbf2898e259b2e84f