Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Rien, van Haperen"'
Autor:
Wenjuan Du, Oliver Debski-Antoniak, Dubravka Drabek, Rien van Haperen, Melissa van Dortmondt, Joline van der Lee, Ieva Drulyte, Frank J. M. van Kuppeveld, Frank Grosveld, Daniel L. Hurdiss, Berend-Jan Bosch
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Porcine deltacoronavirus (PDCoV) is an emerging enteric pathogen that has recently been detected in humans. Despite this zoonotic concern, the antigenic structure of PDCoV remains unknown. The virus relies on its spike (S) protein for cell e
Externí odkaz:
https://doaj.org/article/9dcf63e5b3054d1fac1699924a218ec5
Autor:
Rick Janssens, Rien van Haperen, Michael van der Reijden, Alex Maas, Jingsong Wang, Frank Grosveld, Dubravka Drabek
Publikováno v:
Frontiers in Chemical Biology, Vol 3 (2024)
ObjectiveMesothelin (MSLN) is an attractive target for anticancer therapeutics and bioimaging reagents that utilize antibodies. This study was aimed at developing a novel human anti-MSLN single-domain antibody that exclusively binds to the membrane-a
Externí odkaz:
https://doaj.org/article/3c74ea07b1e04f779a3a5ebe46da50e4
Autor:
Julien Slagboom, Abigail H. Lewis, Wietse M. Schouten, Rien van Haperen, Mieke Veltman, Mátyás A. Bittenbinder, Freek J. Vonk, Nicholas R. Casewell, Frank Grosveld, Dubravka Drabek, Jeroen Kool
Publikováno v:
Toxicon: X, Vol 21, Iss , Pp 100185- (2024)
Snakebite envenoming is a priority Neglected Tropical Disease that causes an estimated 81,000–135,000 fatalities each year. The development of a new generation of safer, affordable, and accessible antivenom therapies is urgently needed. With this g
Externí odkaz:
https://doaj.org/article/aa72a3429ba844ee87def2003bd12c3d
Autor:
Chunyan Wang, Emma L. Hesketh, Tatiana M. Shamorkina, Wentao Li, Peter J. Franken, Dubravka Drabek, Rien van Haperen, Sarah Townend, Frank J. M. van Kuppeveld, Frank Grosveld, Neil A. Ranson, Joost Snijder, Raoul J. de Groot, Daniel L. Hurdiss, Berend-Jan Bosch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Human coronavirus OC43 causes respiratory disease and is maintained in the human population through recurring infections. Here, by extensive structural analyses, the authors provide insights into the binding sites and breadth of neutralizing antibodi
Externí odkaz:
https://doaj.org/article/a254f75862064c1d9048eaf549552960
Autor:
Wenjuan Du, Rick Janssens, Anna Z. Mykytyn, Wentao Li, Dubravka Drabek, Rien van Haperen, Marianthi Chatziandreou, Melanie Rissmann, Joline van der Lee, Melissa van Dortmondt, Itziar Serna Martin, Frank J. M. van Kuppeveld, Daniel L. Hurdiss, Bart L. Haagmans, Frank Grosveld, Berend-Jan Bosch
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Emerging SARS-CoV-2 variants have accrued mutations within the spike protein rendering most therapeutic monoclonal antibodies against COVID-19 ineffective. Hence there is an unmet need for broad-spectrum mAb treatments for COVID-19 that are more resi
Externí odkaz:
https://doaj.org/article/a2e974cb90cd4149a3c38cfea0d08f4d
Autor:
Chunyan Wang, Rien van Haperen, Javier Gutiérrez-Álvarez, Wentao Li, Nisreen M. A. Okba, Irina Albulescu, Ivy Widjaja, Brenda van Dieren, Raul Fernandez-Delgado, Isabel Sola, Daniel L. Hurdiss, Olalekan Daramola, Frank Grosveld, Frank J. M. van Kuppeveld, Bart L. Haagmans, Luis Enjuanes, Dubravka Drabek, Berend-Jan Bosch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Here, the authors report the isolation and characterization of two human monoclonal antibodies (mAbs) from immunized mice with trimeric spike ectodomains of three human betacoronaviruses HCoV-OC43, SARS-CoV and MERSCoV, and show that while exhibiting
Externí odkaz:
https://doaj.org/article/db6da7f5d9bb4e1c916d69bc00d5ab39
Autor:
Chunyan Wang, Wentao Li, Dubravka Drabek, Nisreen M. A. Okba, Rien van Haperen, Albert D. M. E. Osterhaus, Frank J. M. van Kuppeveld, Bart L. Haagmans, Frank Grosveld, Berend-Jan Bosch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
Vaccines and targeted therapeutics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently lacking. Here, the authors report a human monoclonal antibody capable of neutralizing both authentic SARS-CoV and SARS-CoV-2 by targetin
Externí odkaz:
https://doaj.org/article/d72494b81b034a06b5cf561dbf0e29c0
Autor:
Ivy Widjaja, Chunyan Wang, Rien van Haperen, Javier Gutiérrez-Álvarez, Brenda van Dieren, Nisreen M.A. Okba, V. Stalin Raj, Wentao Li, Raul Fernandez-Delgado, Frank Grosveld, Frank J. M. van Kuppeveld, Bart L. Haagmans, Luis Enjuanes, Dubravka Drabek, Berend-Jan Bosch
Publikováno v:
Emerging Microbes and Infections, Vol 8, Iss 1, Pp 516-530 (2019)
ABSTRACTThe Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus that causes severe and often fatal respiratory disease in humans. Efforts to develop antibody-based therapies have focused on neutralizing antibodies that target
Externí odkaz:
https://doaj.org/article/c5a58e9203e14de48fe994d1b6032c31
Autor:
Chunyan Wang, Wentao Li, Dubravka Drabek, Nisreen M. A. Okba, Rien van Haperen, Albert D. M. E. Osterhaus, Frank J. M. van Kuppeveld, Bart L. Haagmans, Frank Grosveld, Berend-Jan Bosch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/9e9fe0b040a04b328eabcac61f34da4e
Autor:
Xin Gan, Qianqian Shan, He Li, Rick Janssens, Yuqiang Shen, Yun He, Fei Chen, Rien van Haperen, Dubravka Drabek, Jin Li, Yang Zhang, Jiuqiao Zhao, Beibei Qin, Ming-Jin Jheng, Victor Chen, Jingsong Wang, Yiping Rong, Frank Grosveld
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 119(32):e2200879119. National Academy of Sciences
The value of anti-CTLA-4 antibodies in cancer therapy is well established. However, the broad application of currently available anti-CTLA-4 therapeutic antibodies is hampered by their narrow therapeutic index. It is therefore challenging and attract