Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Rieko Ohki"'
Autor:
Yu Chen, Tatsuki Yamamoto, Yura Takahashi, Tomoka Moro, Tomoko Tajima, Yukiko Sakaguchi, Naoaki Sakata, Akihiko Yokoyama, Susumu Hijioka, Akane Sada, Yuko Tabata, Rieko Ohki
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-13 (2023)
Abstract Insulin signaling often plays a role in the regulation of cancer, including tumor initiation, progression, and response to treatment. In addition, the insulin-regulated PI3K-Akt-mTOR pathway plays an important role in the regulation of islet
Externí odkaz:
https://doaj.org/article/eb742293dced49c3a1be0d07a11e3fbf
Autor:
Ylenia Capodanno, Yu Chen, Joerg Schrader, Mitsuhiro Tomosugi, Shoiciro Sumi, Akihiko Yokoyama, Nobuyoshi Hiraoka, Rieko Ohki
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 979-992 (2021)
Genomic analysis of Pancreatic Neuroendocrine Tumors (PanNETs) has revealed that these tumors often lack mutations in typical cancer-related genes such as the tumor suppressor gene p53. Instead, PanNET tumorigenesis usually involves mutations in spec
Externí odkaz:
https://doaj.org/article/38ca6b0b82e74238812168db154ea213
Autor:
Yu Chen, Rieko Ohki
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 4098 (2020)
p53 is a well-known tumor suppressor gene and one of the most extensively studied genes in cancer research. p53 functions largely as a transcription factor and can trigger a variety of antiproliferative programs via induction of its target genes. We
Externí odkaz:
https://doaj.org/article/802466fc970d4f1b83b18c8790c80fde
Autor:
Naoaki Sakata, Yohko Yamaguchi, Yu Chen, Masayuki Shimoda, Gumpei Yoshimatsu, Michiaki Unno, Shoichiro Sumi, Rieko Ohki
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187927 (2017)
Islet transplantation is a useful cell replacement therapy that can restore the glycometabolic function of severe diabetic patients. It is known that many transplanted islets failed to engraft, and thus, new approaches for overcoming graft loss that
Externí odkaz:
https://doaj.org/article/426a8937c6eb447ca9d7ff05b2e6d00a
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123387 (2015)
Accumulating evidence suggests that RNAs interacting with genomic regions play important roles in the regulation of genome functions, including X chromosome inactivation and gene expression. However, to our knowledge, no non-biased methods of identif
Externí odkaz:
https://doaj.org/article/f551e97ead824ed4b2656f915299985d
Autor:
Yu Chen, Yura Takahashi, Tomoka Moro, Tomoko Tajima, Yukiko Sakaguchi, Tatsuki Yamamoto, Akihiko Yokoyama, Susumu Hijioka, Akane Sada, Yuko Tabata, Rieko Ohki
Insulin signaling often plays a role in the regulation of cancer including tumor initiation, progression, and response to treatment. In addition, the insulin-regulated PI3K-Akt-mTOR pathway plays an important role in the regulation of islet cell prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d1f80e91226b481d59612493f2c2863
https://doi.org/10.1101/2022.10.21.507065
https://doi.org/10.1101/2022.10.21.507065
Autor:
Makoto Miyazaki, Ayaka Nakabo, Yoshiko Nagano, Yuko Nagamura, Kazuyoshi Yanagihara, Rieko Ohki, Yoshikazu Nakamura, Kiyoko Fukami, Jun Kawamoto, Kenji Umayahara, Masaru Sakamoto, Keiichi Iwaya, Hideki Yamaguchi
Publikováno v:
Cancer Letters. 553:215983
Peritoneal metastasis is one of the most frequent causes of death in several types of advanced cancers; however, the underlying molecular mechanisms remain largely unknown. In this study, we exploited multicolor fluorescent lineage tracking to invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d514799c2fec8678939bcd48d93ab992
https://doi.org/10.1016/j.canlet.2022.215983
https://doi.org/10.1016/j.canlet.2022.215983
Autor:
Yoshiko Nagano, Toshio Imai, Yuko Nagamura, Masato Tanaka, Masakazu Yashiro, Rieko Ohki, Kazuyoshi Yanagihara, Shingo Miyamoto, Ryuichi Sakai, Kazuki Sasaki, Takeshi Kawamura, Makoto Miyazaki, Hideki Yamaguchi
Publikováno v:
Cancer letters. 526
Diffuse-type gastric carcinoma (DGC) has a poor prognosis due to its rapid diffusive infiltration and frequent peritoneal dissemination. DGC is associated with massive fibrosis caused by aberrant proliferation of cancer-associated fibroblasts (CAFs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2f4908f3f67df329290ab52bc98c4f
https://pubmed.ncbi.nlm.nih.gov/34775002
https://pubmed.ncbi.nlm.nih.gov/34775002
Autor:
Yuko Tabata, Kazuhiro Okumura, Akane Sada, Yu Chen, Kiyono Aoki, Masaki Fukuyo, Megumi Saito, Rieko Ohki, Atsushi Kaneda, Yuichi Wakabayashi
Publikováno v:
The Journal of investigative dermatology. 142(4)
Squamous cell carcinomas (SCCs) are one of the most frequent solid cancer types in humans and are derived from stratified epithelial cells found in various organs. SCCs derived from various organs share common important properties, including genomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88979ba56d823b9eee3374157f7881f
https://pubmed.ncbi.nlm.nih.gov/34592332
https://pubmed.ncbi.nlm.nih.gov/34592332
Autor:
Kiyono Aoki, Yuko Otani, Yuko Tabata, Aoze Su, Tomohiko Ohwada, Rieko Ohki, Akane Sada, Kouhei Tsumoto, Satoru Nagatoishi, Siyuan Wang
Publikováno v:
Chemical and Pharmaceutical Bulletin.
Protein-protein interactions (PPIs) are often mediated by helical, strand and/or coil secondary structures at the interface regions. We previously showed that non-naturally occurring, stable helical trimers of bicyclic β-amino acids (Abh) with all-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741174f4b36b4d27a9f219e315434418
https://doi.org/10.1248/cpb.c21-00238
https://doi.org/10.1248/cpb.c21-00238