Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Riekje, Winzer"'
Autor:
Stephan Menzel, Yinghui Duan, Julia Hambach, Birte Albrecht, Dorte Wendt-Cousin, Riekje Winzer, Eva Tolosa, Anne Rissiek, Andreas H. Guse, Friedrich Haag, Tim Magnus, Friedrich Koch-Nolte, Björn Rissiek
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
CD39 is the major enzyme controlling the levels of extracellular adenosine triphosphate (ATP) via the stepwise hydrolysis of ATP to adenosine diphosphate (ADP) and adenosine monophosphate (AMP). As extracellular ATP is a strong promoter of inflammati
Externí odkaz:
https://doaj.org/article/ede936c25e8b4acd80c5bcc8d2044e79
Autor:
Riekje Winzer, Du Hanh Nguyen, Felix Schoppmeier, Filippo Cortesi, Nicola Gagliani, Eva Tolosa
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
An increase in the extracellular concentration of ATP as a consequence of cellular stress or cell death results in the activation of immune cells. To prevent inflammation, extracellular ATP is rapidly metabolized to adenosine, which deploys an anti-i
Externí odkaz:
https://doaj.org/article/5567e81fc7a0470690b8c4265e211e21
Autor:
Enja Schneider, Riekje Winzer, Anne Rissiek, Isabell Ricklefs, Catherine Meyer-Schwesinger, Franz L. Ricklefs, Andreas Bauche, Jochen Behrends, Rudolph Reimer, Santra Brenna, Hauke Wasielewski, Melchior Lauten, Björn Rissiek, Berta Puig, Filippo Cortesi, Tim Magnus, Ralf Fliegert, Christa E. Müller, Nicola Gagliani, Eva Tolosa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Ectonucleotidases associated to regulatory T cells are known modulators in the inflammatory environment. Here the authors describe CD8 T cell-derived extracellular vesicles bearing CD73 and suggest they function as an additional intrinsic modulator o
Externí odkaz:
https://doaj.org/article/423c6b103e9d4f51bf3e93a6880c1a59
Autor:
Julie Pelletier, Jean Sévigny, Laura Schäkel, Salahuddin Mirza, Riekje Winzer, Vittoria Lopez, Riham Idris, Haneen Al-Hroub, Eva Tolosa, Christa E Müller
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 8 (2022)
Background An important mechanism, by which cancer cells achieve immune escape, is the release of extracellular adenosine into their microenvironment. Adenosine activates adenosine A2A and A2B receptors on immune cells constituting one of the stronge
Externí odkaz:
https://doaj.org/article/8abf22ac4a1d4fadacc1d985d35a7a52
Autor:
Mario Leutert, Yinghui Duan, Riekje Winzer, Stephan Menzel, Eva Tolosa, Tim Magnus, Michael O. Hottiger, Friedrich Koch-Nolte, Björn Rissiek
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mouse T cells express the ecto-ADP-ribosyltransferase ARTC2.2, which can transfer the ADP-ribose group of extracellular nicotinamide adenine dinucleotide (NAD+) to arginine residues of various cell surface proteins thereby influencing their function.
Externí odkaz:
https://doaj.org/article/71ad7440b5414b539c0e907e5ddd60d5
Autor:
Enja Schneider, Anne Rissiek, Riekje Winzer, Berta Puig, Björn Rissiek, Friedrich Haag, Hans-Willi Mittrücker, Tim Magnus, Eva Tolosa
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Extracellular adenine nucleotides participate in cell-to-cell communication and modulate the immune response. The concerted action of ectonucleotidases CD39 and CD73 plays a major role in the local production of anti-inflammatory adenosine, but both
Externí odkaz:
https://doaj.org/article/b387e9a6797446e6a1e8913e5eb41487
Autor:
Ines Sophie Schädlich, Riekje Winzer, Joschi Stabernack, Eva Tolosa, Tim Magnus, Björn Rissiek
Publikováno v:
Seminars in Immunopathology.
In ischemic stroke, the primary neuronal injury caused by the disruption of energy supply is further exacerbated by secondary sterile inflammation. The inflammatory cascade is largely initiated by the purine adenosine triphosphate (ATP) which is exte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49a0b1029677284902023435ba16ae88
https://doi.org/10.1007/s00281-023-00987-3
https://doi.org/10.1007/s00281-023-00987-3
Autor:
Riekje Winzer, Arnau Serracant‐Prat, Valerie J. Brock, Carolina Pinto‐Espinoza, Björn Rissiek, Miriam Amadi, Niklas Eich, Anne Rissiek, Enja Schneider, Tim Magnus, Andreas H. Guse, Björn‐Philipp Diercks, Friedrich Koch‐Nolte, Eva Tolosa
Publikováno v:
European journal of immunologyReferences. 52(11)
Extracellular ATP activates the P2X7 receptor, leading to inflammasome activation and release of pro-inflammatory cytokines in monocytes. However, a detailed analysis of P2X7 receptor expression and function in the human T cell compartment has not be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac26bac741665bba65387613eb21676f
https://pubmed.ncbi.nlm.nih.gov/36178227
https://pubmed.ncbi.nlm.nih.gov/36178227
Autor:
Laura Schäkel, Salahuddin Mirza, Riekje Winzer, Vittoria Lopez, Riham Idris, Haneen Al-Hroub, Julie Pelletier, Jean Sévigny, Eva Tolosa, Christa E Müller
Publikováno v:
Journal for ImmunoTherapy of Cancer. 10:e004660
BackgroundAn important mechanism, by which cancer cells achieve immune escape, is the release of extracellular adenosine into their microenvironment. Adenosine activates adenosine A2A and A2B receptors on immune cells constituting one of the stronges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2048c73c4e6125db35a0fd9ff31ccd9c
https://doi.org/10.1136/jitc-2022-004660
https://doi.org/10.1136/jitc-2022-004660
Autor:
Francesca Odoardi, Eva Tolosa, Anette Rosche, Wolfgang Dohle, Leon Hosang, Andreas H. Guse, Barry V. L. Potter, Sabine Windhorst, Riekje Winzer, Anke Löhndorf, Andreas Bauche, Alexander Flügel, Stephen Marry, Björn-Philipp Diercks, Sissy-Alina Waschkowski
T cell activation starts with formation of second messengers that release Ca2+ from the endoplasmic reticulum (ER) and thereby activate store-operated Ca2+ entry (SOCE), one of the essential signals for T cell activation. Recently, the steroidal 2-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb2c8fa726a5b9cc25114b1dc923648
https://ora.ox.ac.uk/objects/uuid:0625f9f7-6c8f-43ac-89bf-0f8646db7cac
https://ora.ox.ac.uk/objects/uuid:0625f9f7-6c8f-43ac-89bf-0f8646db7cac
