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pro vyhledávání: '"Rieke Ringel"'
Publikováno v:
Biochemistry. 46:5341-5348
The oncoprotein Ras is anchored in lipid membranes due to its C-terminal lipid modification. The ubiquitously expressed Ras nucleotide exchange-factor hSOSI promotes nucleotide exchange and thus Ras activation. This reaction is enhanced by a positive
Autor:
Patrick Cramer, Alessandro Vannini, Anselm G. Kusser, Otto Berninghausen, Rieke Ringel, George A. Kassavetis
Publikováno v:
Cell
SummaryRNA polymerase III (Pol III) transcribes short RNAs required for cell growth. Under stress conditions, the conserved protein Maf1 rapidly represses Pol III transcription. We report the crystal structure of Maf1 and cryo-electron microscopic st