Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Rieke Fischer"'
Autor:
Diana Schaufler, David F. Ast, Hannah L. Tumbrink, Nima Abedpour, Lukas Maas, Ayla E. Schwäbe, Inga Spille, Stefanie Lennartz, Jana Fassunke, Mihaela Aldea, Benjamin Besse, David Planchard, Lucia Nogova, Sebastian Michels, Carsten Kobe, Thorsten Persigehl, Theresa Westphal, Sophia Koleczko, Rieke Fischer, Jan-Phillip Weber, Janine Altmüller, Roman K. Thomas, Sabine Merkelbach-Bruse, Oliver Gautschi, Laura Mezquita, Reinhard Büttner, Jürgen Wolf, Martin Peifer, Johannes Brägelmann, Matthias Scheffler, Martin L. Sos
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-12 (2021)
Abstract Activation of MAPK signaling via BRAF mutations may limit the activity of EGFR inhibitors in EGFR-mutant lung cancer patients. However, the impact of BRAF mutations on the selection and fitness of emerging resistant clones during anti-EGFR t
Externí odkaz:
https://doaj.org/article/2fe94ce5763c49248add719a2c82fe60
Autor:
Sebastian Y. F. Michels, Andreas H. Scheel, Thomas Wündisch, Johannes M. Heuckmann, Roopika Menon, Michael Puesken, Carsten Kobe, Helen Pasternack, Carina Heydt, Matthias Scheffler, Rieke Fischer, Anne M. Schultheis, Sabine Merkelbach-Bruse, Lukas Heukamp, Reinhard Büttner, Jürgen Wolf
Publikováno v:
npj Precision Oncology, Vol 1, Iss 1, Pp 1-4 (2017)
Abstract Inflammatory myofibroblastic tumors are rare mesenchymal neoplasms frequently harboring oncogenic chromosomal rearrangements, most commonly, involving the ALK (anaplastic lymphoma kinase) gene. Treatment of this molecularly defined subgroup
Externí odkaz:
https://doaj.org/article/33a80232e38044a3a05d9a9bbd74b52a
Autor:
Theresa Reutter, Jana Fassunke, Michael Püsken, Jan-Phillip Weber, Elke Binot, Anna Eisert, Rieke Fischer, Lucia Nogova, Richard Riedel, Diana Schaufler, Heather Scharpenseel, Matthias Scheffler, Holger Schulz, Dirk‐Thomas Waldschmidt, Thomas Zander, Sabine Merkelbach-Bruse, Peter Schirmacher, Reinhard Büttner, Jürgen Wolf, Sebastian Michels
Publikováno v:
JCO Precision Oncology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::537dcdc497bef9629af8b90cb9d696fc
https://doi.org/10.1200/po.22.00467
https://doi.org/10.1200/po.22.00467
Autor:
Martin L. Sos, Roman K. Thomas, Jürgen Wolf, Reinhard Buettner, Martin Peifer, William Pao, Johannes Berg, Lukas C. Heukamp, Sascha Ansén, Peter Nuernberg, Johannes M. Heuckmann, Alexandra Florin, Christian Müller, Hongbin Ji, Janine Altmüller, Christian Becker, Carina Heydt, Helen Pasternack, Michaela A. Ihle, Jana Fassunke, Hans-Ulrich Schildhaus, Katharina König, Kerstin Albus, Rieke Fischer, Sebastian Michels, Marc Bos, Sabine Merkelbach-Bruse, Thorsten Persigehl, Christine M. Lovly, Lydia Meder, Lynnette Fernandez-Cuesta, Andreas H. Scheel, llona Dahmen, Dennis Plenker, Matthias Scheffler, Sandra Ortiz-Cuaran
Concomitant inhibition of MEK and EGFR is synergistic in PC9KRAS-G12S and HCC827KRAS-G12S cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b61377c2454362cbbfe49a2f4a2410
https://doi.org/10.1158/1078-0432.22460892.v1
https://doi.org/10.1158/1078-0432.22460892.v1
Autor:
Martin L. Sos, Roman K. Thomas, Jürgen Wolf, Reinhard Buettner, Martin Peifer, William Pao, Johannes Berg, Lukas C. Heukamp, Sascha Ansén, Peter Nuernberg, Johannes M. Heuckmann, Alexandra Florin, Christian Müller, Hongbin Ji, Janine Altmüller, Christian Becker, Carina Heydt, Helen Pasternack, Michaela A. Ihle, Jana Fassunke, Hans-Ulrich Schildhaus, Katharina König, Kerstin Albus, Rieke Fischer, Sebastian Michels, Marc Bos, Sabine Merkelbach-Bruse, Thorsten Persigehl, Christine M. Lovly, Lydia Meder, Lynnette Fernandez-Cuesta, Andreas H. Scheel, llona Dahmen, Dennis Plenker, Matthias Scheffler, Sandra Ortiz-Cuaran
Supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83ce9cf1e2f74d9d238de9825be4cb3
https://doi.org/10.1158/1078-0432.22460907.v1
https://doi.org/10.1158/1078-0432.22460907.v1
Autor:
Martin L. Sos, Roman K. Thomas, Jürgen Wolf, Reinhard Buettner, Martin Peifer, William Pao, Johannes Berg, Lukas C. Heukamp, Sascha Ansén, Peter Nuernberg, Johannes M. Heuckmann, Alexandra Florin, Christian Müller, Hongbin Ji, Janine Altmüller, Christian Becker, Carina Heydt, Helen Pasternack, Michaela A. Ihle, Jana Fassunke, Hans-Ulrich Schildhaus, Katharina König, Kerstin Albus, Rieke Fischer, Sebastian Michels, Marc Bos, Sabine Merkelbach-Bruse, Thorsten Persigehl, Christine M. Lovly, Lydia Meder, Lynnette Fernandez-Cuesta, Andreas H. Scheel, llona Dahmen, Dennis Plenker, Matthias Scheffler, Sandra Ortiz-Cuaran
Activation of ERBB2 or MET leads to decreased sensitivity to AZD9291 and rociletinib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2dd86286d7696bf9b7afa255459cd3
https://doi.org/10.1158/1078-0432.22460904
https://doi.org/10.1158/1078-0432.22460904
Autor:
Jürgen Wolf, Reinhard Büttner, Mathieu Clement-Ziza, Lukas C. Heukamp, Britta Kaminsky, Thomas Geist, Ulrich Gerigk, Yon-Dschun Ko, Monika Serke, Carina Heydt, Jana Fassunke, Anna Eisert, Rieke Fischer, Sebastian Michels, Katharina König, Frank Ueckeroth, Michael Rauer, Anna Kron, Michaela A. Ihle, Sabine Merkelbach-Bruse, Matthias Scheffler, Rieke Frank
Purpose: KEAP1 and NFE2L2 mutations are associated with impaired prognosis in a variety of cancers and with squamous cell carcinoma formation in non–small cell lung cancer (NSCLC). However, little is known about frequency, histology dependence, mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438570b1ec0685eb9b4c9f90d1ab3452
https://doi.org/10.1158/1078-0432.c.6527654.v1
https://doi.org/10.1158/1078-0432.c.6527654.v1
Autor:
Martin L. Sos, Roman K. Thomas, Jürgen Wolf, Reinhard Buettner, Martin Peifer, William Pao, Johannes Berg, Lukas C. Heukamp, Sascha Ansén, Peter Nuernberg, Johannes M. Heuckmann, Alexandra Florin, Christian Müller, Hongbin Ji, Janine Altmüller, Christian Becker, Carina Heydt, Helen Pasternack, Michaela A. Ihle, Jana Fassunke, Hans-Ulrich Schildhaus, Katharina König, Kerstin Albus, Rieke Fischer, Sebastian Michels, Marc Bos, Sabine Merkelbach-Bruse, Thorsten Persigehl, Christine M. Lovly, Lydia Meder, Lynnette Fernandez-Cuesta, Andreas H. Scheel, llona Dahmen, Dennis Plenker, Matthias Scheffler, Sandra Ortiz-Cuaran
Purpose: To identify novel mechanisms of resistance to third-generation EGFR inhibitors in patients with lung adenocarcinoma that progressed under therapy with either AZD9291 or rociletinib (CO-1686).Experimental Design: We analyzed tumor biopsies fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e662a6890eec82b0f8c48767ccf2e60
https://doi.org/10.1158/1078-0432.c.6524634
https://doi.org/10.1158/1078-0432.c.6524634
Autor:
Martin L. Sos, Roman K. Thomas, Jürgen Wolf, Reinhard Buettner, Martin Peifer, William Pao, Johannes Berg, Lukas C. Heukamp, Sascha Ansén, Peter Nuernberg, Johannes M. Heuckmann, Alexandra Florin, Christian Müller, Hongbin Ji, Janine Altmüller, Christian Becker, Carina Heydt, Helen Pasternack, Michaela A. Ihle, Jana Fassunke, Hans-Ulrich Schildhaus, Katharina König, Kerstin Albus, Rieke Fischer, Sebastian Michels, Marc Bos, Sabine Merkelbach-Bruse, Thorsten Persigehl, Christine M. Lovly, Lydia Meder, Lynnette Fernandez-Cuesta, Andreas H. Scheel, llona Dahmen, Dennis Plenker, Matthias Scheffler, Sandra Ortiz-Cuaran
Targeted and Sanger sequencing results at the EGFR locus for P6 and P7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e81b48ee2be8da8f7783d22fac8ebd1
https://doi.org/10.1158/1078-0432.22460901
https://doi.org/10.1158/1078-0432.22460901
Autor:
Martin L. Sos, Roman K. Thomas, Jürgen Wolf, Reinhard Buettner, Martin Peifer, William Pao, Johannes Berg, Lukas C. Heukamp, Sascha Ansén, Peter Nuernberg, Johannes M. Heuckmann, Alexandra Florin, Christian Müller, Hongbin Ji, Janine Altmüller, Christian Becker, Carina Heydt, Helen Pasternack, Michaela A. Ihle, Jana Fassunke, Hans-Ulrich Schildhaus, Katharina König, Kerstin Albus, Rieke Fischer, Sebastian Michels, Marc Bos, Sabine Merkelbach-Bruse, Thorsten Persigehl, Christine M. Lovly, Lydia Meder, Lynnette Fernandez-Cuesta, Andreas H. Scheel, llona Dahmen, Dennis Plenker, Matthias Scheffler, Sandra Ortiz-Cuaran
Expression of KRASG12S mutant results in decreased sensitivity to AZD9291 and rociletinib in EGFR mutated cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa083fd2bc5cdd84d177fcf5a3f75e3
https://doi.org/10.1158/1078-0432.22460898.v1
https://doi.org/10.1158/1078-0432.22460898.v1