Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating CD8+ T cells

Autor: Riegel, Dania, Romero-Fernández, Elena, Simon, Malte, Adenugba, Akinbami Raphael, Singer, Katrin, Mayr, Roman, Weber, Florian, Kleemann, Mark, Imbusch, Charles D., Kreutz, Marina, Brors, Benedikt, Ugele, Ines, Werner, Jens M., Siska, Peter J., Schmidl, Christian

Publikováno v: In Molecular Cell 16 February 2023 83(4):622-636

Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF

Autor: Delacher, Michael, Imbusch, Charles D., Hotz-Wagenblatt, Agnes, Mallm, Jan-Philipp, Bauer, Katharina, Simon, Malte, Riegel, Dania, Rendeiro, André F., Bittner, Sebastian, Sanderink, Lieke, Pant, Asmita, Schmidleithner, Lisa, Braband, Kathrin L., Echtenachter, Bernd, Fischer, Alexander, Giunchiglia, Valentina, Hoffmann, Petra, Edinger, Matthias, Bock, Christoph, Rehli, Michael, Brors, Benedikt, Schmidl, Christian, Feuerer, Markus

Publikováno v: In Immunity 18 February 2020 52(2):295-312

Cancer-associated cells release citrate to support tumour metastatic progression

Autor: Drexler, Konstantin, Schmidt, Katharina M., Jordan, Katrin, Federlin, Marianne, Milenkovic, Vladimir M., Liebisch, Gerhard, Artati, Anna, Schmidl, Christian, Madej, Gregor, Tokarz, Janina, Cecil, Alexander, Jagla, Wolfgang, Haerteis, Silke, Aung, Thiha, Wagner, Christine, Kolodziejczyk, Maria, Heinke, Stefanie, Stanton, Evan H., Schwertner, Barbara, Riegel, Dania, Wetzel, Christian H., Buchalla, Wolfgang, Proescholdt, Martin, Klein, Christoph A., Berneburg, Mark, Schlitt, Hans J., Brabletz, Thomas, Ziegler, Christine, Parkinson, Eric K., Gaumann, Andreas, Geissler, Edward K., Adamski, Jerzy, Haferkamp, Sebastian, Mycielska, Maria E.

Publikováno v: Life Science Alliance

Cancer-associated stroma is recruited by cancer cells to synthesise and release citrate necessary to support metastatic progression of the disease.
Citrate is important for lipid synthesis and epigenetic regulation in addition to ATP production.

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Cancer-associated cells release citrate to support tumour metastatic progression.

Autor: Drexler K; Department of Dermatology, University Medical Centre, Regensburg, Germany., Schmidt KM; Department of Surgery, University Medical Center, Regensburg, Germany., Jordan K; Department of Surgery, University Medical Center, Regensburg, Germany., Federlin M; Department of Conservative Dentistry and Periodontology, University Medical Center, Regensburg, Germany., Milenkovic VM; Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany., Liebisch G; Institute of Clinical Chemistry and Laboratory Medicine, Regensburg University Hospital, Regensburg, Germany., Artati A; Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany., Schmidl C; Regensburg Center for Interventional Immunology, Regensburg, Germany., Madej G; Department of Structural Biology, Institute of Biophysics and Physical Biochemistry, University of Regensburg, Regensburg, Germany., Tokarz J; Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany., Cecil A; Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany., Jagla W; Institute of Pathology, Kaufbeuren-Ravensburg, Kaufbeuren, Germany., Haerteis S; Institute for Molecular and Cellular Anatomy, University of Regensburg, Regensburg, Germany., Aung T; Institute for Molecular and Cellular Anatomy, University of Regensburg, Regensburg, Germany.; Center of Plastic, Aesthetic, Hand and Reconstructive Surgery, University of Regensburg, Regensburg, Germany., Wagner C; Department of Surgery, University Medical Center, Regensburg, Germany., Kolodziejczyk M; Department of Surgery, University Medical Center, Regensburg, Germany., Heinke S; Department of Surgery, University Medical Center, Regensburg, Germany., Stanton EH; Department of Surgery, University Medical Center, Regensburg, Germany., Schwertner B; Department of Dermatology, University Medical Centre, Regensburg, Germany., Riegel D; Regensburg Center for Interventional Immunology, Regensburg, Germany., Wetzel CH; Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany., Buchalla W; Department of Conservative Dentistry and Periodontology, University Medical Center, Regensburg, Germany., Proescholdt M; Department of Neurosurgery, University Hospital Regensburg, Regensburg, Germany., Klein CA; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany., Berneburg M; Department of Dermatology, University Medical Centre, Regensburg, Germany., Schlitt HJ; Department of Surgery, University Medical Center, Regensburg, Germany., Brabletz T; Department of Experimental Medicine 1, Friedrich-Alexander-University Erlangen, Erlangen, Germany., Ziegler C; Department of Structural Biology, Institute of Biophysics and Physical Biochemistry, University of Regensburg, Regensburg, Germany., Parkinson EK; Centre for Immunobiology and Regenerative Medicine, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK., Gaumann A; Institute of Pathology, Kaufbeuren-Ravensburg, Kaufbeuren, Germany., Geissler EK; Department of Surgery, University Medical Center, Regensburg, Germany., Adamski J; Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.; Lehrstuhl für Experimentelle Genetik, Technische Universität München, Munich, Germany.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Haferkamp S; Department of Dermatology, University Medical Centre, Regensburg, Germany sebastian.haferkamp@ukr.de., Mycielska ME; Department of Surgery, University Medical Center, Regensburg, Germany maria.mycielska@ukr.de.

Publikováno v: Life science alliance [Life Sci Alliance] 2021 Mar 23; Vol. 4 (6). Date of Electronic Publication: 2021 Mar 23 (Print Publication: 2021).