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Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis.

Autor: Engesser J; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Khatri R; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg, Germany., Schaub DP; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg, Germany., Zhao Y; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg, Germany., Paust HJ; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sultana Z; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg, Germany., Asada N; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Riedel JH; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sivayoganathan V; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Peters A; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kaffke A; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Jauch-Speer SL; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Goldbeck-Strieder T; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Puelles VG; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Wenzel UO; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Steinmetz OM; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hoxha E; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Turner JE; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mittrücker HW; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute for Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Wiech T; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Pathology, Division of Nephropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Huber TB; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bonn S; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. s.bonn@uke.de.; Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg, Germany. s.bonn@uke.de.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. s.bonn@uke.de., Krebs CF; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. c.krebs@uke.de.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. c.krebs@uke.de.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. c.krebs@uke.de., Panzer U; Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. panzer@uke.de.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. panzer@uke.de.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. panzer@uke.de.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 19; Vol. 15 (1), pp. 8220. Date of Electronic Publication: 2024 Sep 19.

CD4 ⁺ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12.

Autor: Paust HJ; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Song N; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., De Feo D; Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland., Asada N; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Tuzlak S; Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland., Zhao Y; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg 20246, Germany., Riedel JH; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Hellmig M; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Sivayoganathan A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Peters A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Kaffke A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Borchers A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Wenzel UO; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Steinmetz OM; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Tiegs G; Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Meister E; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Mack M; Department of Nephrology, University Hospital Regensburg, Regensburg 93042, Germany., Kurts C; Institute of Molecular Medicine and Experimental Immunology, University Hospital Bonn, Bonn 53127, Germany., von Vietinghoff S; Nephrology Section, Medical Clinic 1, University Hospital Bonn, Bonn 53127, Germany., Lindenmeyer MT; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Hoxha E; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Stahl RAK; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Huber TB; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Bonn S; Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Meyer-Schwesinger C; Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Wiech T; Institute of Pathology, Division of Nephropathology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Turner JE; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Becher B; Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland., Krebs CF; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Panzer U; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Mar 15; Vol. 15 (687), pp. eadd6137. Date of Electronic Publication: 2023 Mar 15.

IL-17 Receptor C Signaling Controls CD4 ⁺ T H 17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases.

Autor: Schmidt T; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Luebbe J; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division of Translational Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kilian C; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division of Translational Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Riedel JH; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division of Translational Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hiekmann S; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division of Translational Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Asada N; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division of Translational Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ginsberg P; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division of Translational Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Robben L; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division of Translational Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Song N; Division of Translational Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of ICU, The First Affiliated Hospital of Harbin Medical University, Harbin, China., Kaffke A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division of Translational Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Peters A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division of Translational Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Borchers A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division of Translational Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Flavell RA; Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut.; Howard Hughes Medical Institute, Yale University, New Haven, Connecticut., Gagliani N; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department for General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institute and University Hospital, Stockholm, Sweden., Pelzcar P; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Huber S; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Huber TB; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Turner JE; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Paust HJ; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division of Translational Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Krebs CF; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division of Translational Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Panzer U; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division of Translational Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2021 Dec; Vol. 32 (12), pp. 3081-3098.

Tissue-specific therapy in immune-mediated kidney diseases: new ARGuments for targeting the IL-23/IL-17 axis.

Autor: Krebs CF; Division of Translational Immunology, III. Department of Medicine.; Hamburg Center for Translational Immunology (HCTI), and.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Turner JE; Hamburg Center for Translational Immunology (HCTI), and.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Riedel JH; Division of Translational Immunology, III. Department of Medicine.; Hamburg Center for Translational Immunology (HCTI), and.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Panzer U; Division of Translational Immunology, III. Department of Medicine.; Hamburg Center for Translational Immunology (HCTI), and.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2021 Jun 15; Vol. 131 (12).