An exploration of the methods to determine the protein‐specific synthesis and breakdown rates in vivo in humans

Autor: Simon Doessing, Grith Højfeldt, Kasper Dideriksen, Marcus Moberg, Rie Harboe Nielsen, Søren Reitelseder, Gerrit van Hall, Eva Blomstrand, Rasmus Bechshoeft, Lars Holm

Publikováno v: Physiological Reports, Vol 7, Iss 17, Pp n/a-n/a (2019)
Holm, L, Dideriksen, K, Nielsen, R H, Doessing, S, Bechshoeft, R L, Højfeldt, G, Moberg, M, Blomstrand, E, Reitelseder, S & van Hall, G 2019, ' An exploration of the methods to determine the protein-specific synthesis and breakdown rates in vivo in humans ', Physiological Reports, vol. 7, no. 17, e14143 . https://doi.org/10.14814/phy2.14143
Physiological Reports

The present study explores the methods to determine human in vivo protein‐specific myofibrillar and collagenous connective tissue protein fractional synthesis and breakdown rates. We found that in human myofibrillar proteins, the protein‐bound tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f90ffb30f1ba56833447920e6571a1f
https://doaj.org/article/fdf0890a15854be4b41c8c2dabcdb5b0

Tendon protein synthesis rate in classic Ehlers-Danlos patients can be stimulated with insulin-like growth factor-I

Autor: Lars Holm, Lars Remvig, Jacob Kildevang Jensen, Rie Harboe Nielsen, Michael Kjaer, Katja M. Heinemeier

Publikováno v: Journal of Applied Physiology. 117:694-698

The classic form of Ehlers-Danlos syndrome (cEDS) is an inherited connective tissue disorder, where mutations in type V collagen-encoding genes result in abnormal collagen fibrils. Thus the cEDS patients have pathological connective tissue morphology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a763cfeacca4aad3d77b50c7c5b4a6
https://doi.org/10.1152/japplphysiol.00157.2014

The single-biopsy approach in determining protein synthesis in human slow-turning-over tissue: use of flood-primed, continuous infusion of amino acid tracers

Autor: Søren Reitelseder, Lars Holm, Michael Kjaer, Kasper Dideriksen, Rie Harboe Nielsen, Jacob Bülow

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 306:E1330-E1339

Muscle protein synthesis (MPS) rate is determined conventionally by obtaining two or more tissue biopsies during a primed, continuous infusion of a stable isotopically labeled amino acid. The purpose of the present study was to test whether tracer pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9882d6080dc268936256e1f3d268851
https://doi.org/10.1152/ajpendo.00084.2014

Differential satellite cell density of type I and II fibres with lifelong endurance running in old men

Autor: Abigail L. Mackey, Anders Karlsen, Ulla Ramer Mikkelsen, Stig Peter Magnusson, Michael Kjaer, Rie Harboe Nielsen, Christian Couppé

Publikováno v: Acta Physiologica; Vol 210

Aim To investigate the influence of lifelong endurance running on the satellite cell pool of type I and type II fibres in healthy human skeletal muscle. Methods Muscle biopsies were collected from 15 healthy old trained men (O-Tr) who had been runnin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e010b0a1b03aceeabd5eb3ffa1578313

The influence of physical activity during youth on structural and functional properties of the Achilles tendon

Autor: Jytte Overgaard Larsen, Vuokko Kovanen, A Lenskjold, Michael Kjaer, Rie Harboe Nielsen, M. Kongsgaard, Per Aagaard, Stig Peter Magnusson

Publikováno v: Scandinavian Journal of Medicine & Science in Sports. 25:25-31

Achilles tendinopathy is a highly prevalent sports injury. Animal studies show a growth response in tendons in response to loading in the immature phase but not after puberty maturation. The aim of this investigation was to examine the structural and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b860f29d5980704c759184c99157b64
https://doi.org/10.1111/sms.12143