Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rie Hantani"'
Autor:
Wataru Asano, Rie Hantani, Toru Uhara, François Debaene, Akihiro Nomura, Keishi Yamaguchi, Tsuyoshi Adachi, Kazuki Otake, Kazuhito Harada, Yoshiji Hantani
Publikováno v:
SLAS Discovery, Vol 29, Iss 2, Pp 100125- (2024)
Protein-protein interactions (PPIs) play a crucial role in most biological processes and are important targets in the development of therapeutic agents. However, small molecule drug discovery that targets PPIs remains very challenging. Targeting hot
Externí odkaz:
https://doaj.org/article/51ffe6d8f0bb4c71b052080e3f45db04
Autor:
Kazuki Otake, Minoru Ubukata, Noboru Nagahashi, Naoki Ogawa, Yoshiji Hantani, Rie Hantani, Tsuyoshi Adachi, Akihiro Nomura, Keishi Yamaguchi, Mariko Maekawa, Hideaki Mamada, Takahisa Motomura, Motohide Sato, Kazuhito Harada
Publikováno v:
ACS Medicinal Chemistry Letters. 14:658-665
Autor:
Yoshiji Hantani, Kiyosei Iio, Rie Hantani, Kayo Umetani, Toshihiro Sato, Tracy Young, Katelyn Connell, Sam Kintz, Joshua Salafsky
Publikováno v:
FEBS Open Bio, Vol 8, Iss 9, Pp 1412-1423 (2018)
Many clinically approved protein kinase inhibitors stabilize an inactive conformation of their kinase target. Such inhibitors are generally highly selective compared to active conformation inhibitors, and consequently, general methods to identify inh
Externí odkaz:
https://doaj.org/article/8d0437040b1b4dbdb797c18f711baa16
Autor:
Kyoko Fukushima, Rie Hantani, Shiori Naruoka, Yukiyo Toyonaga, Yuji Hori, Koichi Aoyagi, Hiroshi Yamanaka, Susumu Miyazaki, Atsuo Tanimoto, Seiji Kawashita, Yoshiji Hantani
Publikováno v:
Chemical Biology & Drug Design. 98:914-929
The development of small molecule inhibitors of programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) has drawn research interest for the treatment of cancer. Recently, we reported the discovery of a novel dimeric core small molecule PD
Autor:
Rie Hantani, Kyoko Fukushima, Koichi Aoyagi, Yukiyo Toyonaga, Hiroshi Yamanaka, Yuji Hori, Seiji Kawashita, Shiori Naruoka, Yoshiji Hantani, Susumu Miyazaki, Atsuo Tanimoto
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2464-2467
The development of small molecule inhibitors of PD-1/PD-L1 is eagerly anticipated for treatment of cancer. We focused on the symmetry of the ternary complex structure of reported small molecule ligands and hPD-L1 homodimers, and designed partially- o
Autor:
Tracy A. Young, Toshihiro Sato, Sam Kintz, Kayo Umetani, Kiyosei Iio, Rie Hantani, Joshua Salafsky, Yoshiji Hantani, Katelyn Connell
Publikováno v:
FEBS Open Bio
Many clinically approved protein kinase inhibitors stabilize an inactive conformation of their kinase target. Such inhibitors are generally highly selective compared to active conformation inhibitors, and consequently, general methods to identify inh
Publikováno v:
SLAS discovery : advancing life sciences RD. 24(8)
Interleukin-2-inducible T-cell kinase (ITK) plays an important role in T-cell signaling and is considered a promising drug target. As the ATP binding sites of protein kinases are highly conserved, the design of selective kinase inhibitors remains a c
Publikováno v:
SLAS discovery : advancing life sciences RD. 24(5)
Atherogenesis has been recognized as a risk factor for lethal cardiovascular diseases. Plasma low-density lipoprotein levels are correlated to the occurrence of atherosclerosis, and their control is critical for both the prevention and treatment of t
Autor:
Kawashita, Seiji1 (AUTHOR) seiji.kawashita@jt.com, Aoyagi, Koichi1 (AUTHOR), Fukushima, Kyoko1 (AUTHOR), Hantani, Rie2 (AUTHOR), Naruoka, Shiori2 (AUTHOR), Tanimoto, Atsuo2 (AUTHOR), Hori, Yuji2 (AUTHOR), Toyonaga, Yukiyo2 (AUTHOR), Yamanaka, Hiroshi1 (AUTHOR), Miyazaki, Susumu1 (AUTHOR), Hantani, Yoshiji2 (AUTHOR) yoshiji.hantani@jt.com
Publikováno v:
Chemical Biology & Drug Design. Nov2021, Vol. 98 Issue 5, p914-929. 16p.
Autor:
Hantani, Yoshiji, Iio, Kiyosei, Hantani, Rie, Umetani, Kayo, Sato, Toshihiro, Young, Tracy, Connell, Katelyn, Kintz, Sam, Salafsky, Joshua
Publikováno v:
FEBS Open Bio; Sep2018, Vol. 8 Issue 9, p1412-1423, 12p