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Mitochondrial translation deficiency impairs NAD + ‐mediated lysosomal acidification

Autor: Dongchon Kang, Haruka Hirai, Daiki Setoyama, Takeshi Uchiumi, Takahiro Toshima, Rie Amamoto, Yura Do, Mikako Yagi

Publikováno v: The EMBO Journal. 40

Mitochondrial translation dysfunction is associated with neurodegenerative and cardiovascular diseases. Cells eliminate defective mitochondria by the lysosomal machinery via autophagy. The relationship between mitochondrial translation and lysosomal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b7d9187cc8ff8a28c599299cf4f5bc3
https://doi.org/10.15252/embj.2020105268

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Mitochondrial translation deficiency impairs NAD

Autor: Mikako, Yagi, Takahiro, Toshima, Rie, Amamoto, Yura, Do, Haruka, Hirai, Daiki, Setoyama, Dongchon, Kang, Takeshi, Uchiumi

Publikováno v: The EMBO Journal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e53cbf275dd1f4bad341c0bbf15995d
https://pubmed.ncbi.nlm.nih.gov/33528041

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Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration

Autor: Mikako Yagi, Dongchon Kang, Daiki Setoyama, Noriaki Sagata, Takeshi Uchiumi, Yuichi Matsushima, Rie Amamoto

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)

Mitochondrial dysfunction is a critical step in the pathogenesis of many neurodegenerative diseases. The p32/ C1qbp gene functions as an essential RNA and protein chaperone in mitochondrial translation, and is indispensable for embryonic development.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6058304ceb0a894de9c285c8023f24f
https://doi.org/10.1038/s41598-017-15414-5

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Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity

Autor: Takeshi Uchiumi, Yuichi Matsushima, Keisuke Monji, Rie Amamoto, Takashi Matsumoto, Daiki Setoyama, Dongchon Kang, Masatoshi Eto, Masaki Shiota, Mikako Yagi

Publikováno v: Oncogenesis
Oncogenesis, Vol 6, Iss 11, Pp 1-11 (2017)

Tumor heterogeneity can be traced back to a small subset of cancer stem cells (CSCs), which can be derived from a single stem cell and show chemoresistance. Recent studies showed that CSCs are sensitive to mitochondrial targeting antibiotics such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6621a966f99deaadf2dad3d5b854d0
https://pubmed.ncbi.nlm.nih.gov/29184058

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Cardiomyocyte-specific loss of mitochondrial p32/C1qbp causes cardiomyopathy and activates stress responses

Autor: Dongchon Kang, Toshiro Saito, Rie Amamoto, Mikako Yagi, Daiki Setoyama, Yuichi Matsushima, Takeshi Uchiumi

Publikováno v: Cardiovascular research. 113(10)

Aims Mitochondria are important organelles, dedicated to energy production. Mitochondrial p32/C1qbp, which functions as an RNA and protein chaperone, interacts with mitochondrial mRNA and is indispensable for mitochondrial function through its regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29527e5c18862a223b345e32280b25e5
https://pubmed.ncbi.nlm.nih.gov/28498888

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Serum depletion induced cancer stem cell-like phenotype due to nitric oxide synthesis in oncogenic HRas transformed cells

Autor: Mikako Yagi, Kazuhito Gotoh, Takashi Matsumoto, Keisuke Monji, Yuichi Matsushima, Takeshi Uchiumi, Donchon Kang, Daiki Setoyama, Rie Amamoto, Saki Hoshizawa

Publikováno v: Oncotarget

// Keisuke Monji 1 , Takeshi Uchiumi 1 , Saki Hoshizawa 1 , Mikako Yagi 1 , Takashi Matsumoto 1 , Daiki Setoyama 1 , Yuichi Matsushima 1 , Kazuhito Gotoh 1 , Rie Amamoto 1, 2 , Donchon Kang 1 1 Department of Clinical Chemistry and Laboratory Medicine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b4a6138c86489080340ef34648005b
https://pubmed.ncbi.nlm.nih.gov/27655692

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The Expression of Ubiquitous Mitochondrial Creatine Kinase Is Downregulated as Prostate Cancer Progression

Autor: Masaki Shiota, Dongchon Kang, Keisuke Monji, Rie Amamoto, Mikako Yagi, Takeshi Uchiumi, Akira Yokomizo, Yoshinao Oda, Seiji Naito, YooHyun Song

Publikováno v: Journal of Cancer

Background: Mitochondria play crucial roles in cell signaling events, interorganellar communication, aging, cell proliferation and apoptosis, and mitochondrial impairment has been shown to accelerate or modulate cancer progression. Ubiquitous mitocho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9a9cfd7ca31bddb3e7d3815337a167
https://pubmed.ncbi.nlm.nih.gov/26722360

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Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction

Autor: Jing Xian Fang, Haruyoshi Yamaza, Kazuaki Nonaka, Rie Amamoto, Takeshi Uchiumi, Mikako Yagi, Shinya Matsumoto, Dongchon Kang, Shinya Takazaki

Publikováno v: Bioscience Reports
Bioscience Reports, Vol 33, Iss 2, p e00021 (2013)

Some mutations of the DHODH (dihydro-orotate dehydrogenase) gene lead to postaxial acrofacial dysostosis or Miller syndrome. Only DHODH is localized at mitochondria among enzymes of the de novo pyrimidine biosynthesis pathway. Since the pyrimidine bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99052f7c972fc21759933f733a55203a
https://doi.org/10.1042/bsr20120097

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Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients

Autor: Haruyoshi Yamaza, Mikako Yagi, Takeshi Uchiumi, Toshiro Saito, Kazuaki Nonaka, Dongchon Kang, Tomotake Kanki, Jing Xian Fang, Shinya Matsumoto, Shinya Takazaki, Rie Amamoto

Publikováno v: Bioscience Reports, Vol 32, Iss 6 (2012)
Bioscience Reports

Miller syndrome is a recessive inherited disorder characterized by postaxial acrofacial dysostosis. It is caused by dysfunction of the DHODH (dihydroorotate dehydrogenase) gene, which encodes a key enzyme in the pyrimidine de novo biosynthesis pathwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044da3858a35bbc20d51613747c74711
http://www.bioscirep.org/bsr/032/0631/bsr0320631.htm

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Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomy

Autor: Tomohiro Samori, Mikako Yagi, Kentaro Kuroiwa, Masazumi Tsuneyoshi, Takeshi Uchiumi, Dongchon Kang, Shoji Tokunaga, Akira Yokomizo, Hisahide Hiura, Rie Amamoto, YooHyun Song, Seiji Kato, Seiji Naito, Yoshinao Oda

Publikováno v: Cancer science. 102(3)

Mitochondria are key organelles for ATP production and apoptosis. Therefore, impairment of mitochondria can modulate or accelerate cancer progression. p32, originally identified as a pre-mRNA splicing factor SF2/ASF-associated protein, is localized p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57518b267636028bf87924d7e6628a97
https://pubmed.ncbi.nlm.nih.gov/21205079

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