Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Rie, Matsushima"'
Autor:
Gen Kuroyanagi, Haruhiko Tokuda, Kazuhiko Fujita, Tetsu Kawabata, Go Sakai, Woo Kim, Tomoyuki Hioki, Junko Tachi, Rie Matsushima-Nishiwaki, Takanobu Otsuka, Hiroki Iida, Osamu Kozawa
Publikováno v:
BMC Musculoskeletal Disorders, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Heat shock protein (HSP) 90 functions as a molecular chaperone and is constitutively expressed and induced in response to stress in many cell types. We have previously demonstrated that transforming growth factor-β (TGF-β), the
Externí odkaz:
https://doaj.org/article/d7dab7483c244fb296d6568b40a34bef
Autor:
Hiroki Iida, Takashi Onuma, Daiki Nakashima, Daisuke Mizutani, Takamitsu Hori, Kyohei Ueda, Tomoyuki Hioki, Woo Kim, Yukiko Enomoto, Tomoaki Doi, Rie Matsushima-Nishiwaki, Shinobu Yamaguchi, Junko Tachi, Kumiko Tanabe, Shinji Ogura, Toru Iwama, Osamu Kozawa, Haruhiko Tokuda
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0279011 (2023)
Tramadol is a useful analgesic which acts as a serotonin and noradrenaline reuptake inhibitor in addition to μ-opioid receptor agonist. Cytoplasmic serotonin modulates the small GTPase activity through serotonylation, which is closely related to the
Externí odkaz:
https://doaj.org/article/639ba1726d7d435c904555b3e4f46a02
Autor:
Gen Kuroyanagi, Go Sakai, Takanobu Otsuka, Naohiro Yamamoto, Kazuhiko Fujita, Tetsu Kawabata, Rie Matsushima-Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-8 (2021)
Abstract Background Heat shock protein 22 (HSP22) belongs to class I of the small HSP family that displays ubiquitous expression in osteoblasts. We previously demonstrated that prostaglandin F2α (PGF2α), a potent bone remodeling factor, induces the
Externí odkaz:
https://doaj.org/article/aa50c6de43b44762b74f761572db8ea6
Autor:
Tomoaki Doi, Takamitsu Hori, Takashi Onuma, Daisuke Mizutani, Kyohei Ueda, Yukiko Enomoto, Rie Matsushima‐Nishiwaki, Kumiko Tanabe, Tomoyuki Hioki, Haruhiko Tokuda, Toru Iwama, Hiroki Iida, Osamu Kozawa, Shinji Ogura
Publikováno v:
Acute Medicine & Surgery, Vol 9, Iss 1, Pp n/a-n/a (2022)
Aim In acute medicine, we occasionally treat life‐threatening conditions such as sepsis and trauma, which cause severe thrombocytopenia. Serum thrombopoietin levels have been reported to increase under the condition of thrombocytopenia related to s
Externí odkaz:
https://doaj.org/article/002f25fff2e04eb99f07756a498bf1f4
Autor:
Gen Kuroyanagi, Junko Tachi, Kazuhiko Fujita, Tetsu Kawabata, Go Sakai, Daiki Nakashima, Woo Kim, Kumiko Tanabe, Rie Matsushima-Nishiwaki, Takanobu Otsuka, Hiroki Iida, Osamu Kozawa, Haruhiko Tokuda
Publikováno v:
PLoS ONE, Vol 17, Iss 12 (2022)
Interleukin-6 (IL-6) is a pro-inflammatory and bone-resorptive cytokine that also regulates bone formation. We previously showed that prostaglandin E1 (PGE1) induces the synthesis of IL-6 by activating p44/p42 mitogen-activated protein kinase (MAPK),
Externí odkaz:
https://doaj.org/article/87a922416b5041e3a5590c0733185f28
Autor:
Rie Matsushima-Nishiwaki, Noriko Yamada, Yuria Hattori, Yui Hosokawa, Junko Tachi, Takamitsu Hori, Osamu Kozawa
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
Selective estrogen receptor modulator (SERM) interacts with estrogen receptors and acts as both an agonist or an antagonist, depending on the target tissue. SERM is widely used as a safer hormone replacement therapeutic medicine for postmenopausal os
Externí odkaz:
https://doaj.org/article/7a06bf07ceef4b12aa67bcefb25eef31
Autor:
Kaido Kobayashi, Rie Matsushima-Nishiwaki, Noriko Yamada, Saori Migita, Tomoyuki Hioki, Daisuke Mizutani, Osamu Kozawa
Publikováno v:
Heliyon, Vol 6, Iss 9, Pp e05002- (2020)
Heat shock proteins (HSPs) are induced in response to extracellular stress and manage the quality of proteins as molecular chaperones. HSP70, a highly conserved HSP, has been reported to correlate with the proliferation and migration of human cancer
Externí odkaz:
https://doaj.org/article/c95b8fcb60b543ff8cc047881efa8b07
Autor:
Woo Kim, Kumiko Tanabe, Gen Kuroyanagi, Rie Matsushima-Nishiwaki, Kazuhiko Fujita, Tetsu Kawabata, Go Sakai, Junko Tachi, Tomoyuki Hioki, Daiki Nakashima, Shinobu Yamaguchi, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa, Hiroki Iida
Publikováno v:
Heliyon, Vol 6, Iss 8, Pp e04779- (2020)
Osteoprotegerin (OPG) synthesized by osteoblasts is currently considered a crucial regulator to suppress the formation and function of osteoclasts. We previously showed that the synthesis of OPG is stimulated by prostaglandin F2α (PGF2α) in the inv
Externí odkaz:
https://doaj.org/article/87d544ee505e40fa9018607e7ff1e5e8
Autor:
Kodai Uematsu, Yukiko Enomoto, Takashi Onuma, Masanori Tsujimoto, Tomoaki Doi, Rie Matsushima-Nishiwaki, Haruhiko Tokuda, Shinji Ogura, Hiroki Iida, Osamu Kozawa, Toru Iwama
Publikováno v:
Cellular Physiology and Biochemistry, Vol 49, Iss 4, Pp 1523-1538 (2018)
Background/Aims: Thrombin induces the activation of human platelets through protease-activated receptor (PAR) 1 and PAR4, and Rac, a member of the Rho family of small GTPases, is implicated in PAR activation. We previously reported that phosphorylate
Externí odkaz:
https://doaj.org/article/83136f285ed541e0bd927e4757da2f47
Publikováno v:
Biomedical Research. 43:211-221
Selective estrogen receptor modulator (SERM) binds to estrogen receptors (ERs) and acts as both an agonist or an antagonist, depending on the target tissue. Raloxifene and bazedoxifene as SERMs are currently used hormone replacement medicines for pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbea4a43125523ffc914af5b00680a3
https://doi.org/10.2220/biomedres.43.211
https://doi.org/10.2220/biomedres.43.211