Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features.

Autor: Robbe P; Department of Oncology, University of Oxford, Oxford, UK.; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Ridout KE; Department of Oncology, University of Oxford, Oxford, UK., Vavoulis DV; Department of Oncology, University of Oxford, Oxford, UK., Dréau H; Department of Oncology, University of Oxford, Oxford, UK., Kinnersley B; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK., Denny N; Department of Medicine, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Chubb D; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK., Appleby N; Department of Oncology, University of Oxford, Oxford, UK., Cutts A; Department of Oncology, University of Oxford, Oxford, UK., Cornish AJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK., Lopez-Pascua L; UK Health Security Agency, London, UK., Clifford R; Department of Haematology, University Hospital Limerick, Limerick, Ireland.; Limerick Digital Cancer Research Centre, School of Medicine,University of Limerick, Limerick, Ireland., Burns A; Department of Oncology, University of Oxford, Oxford, UK., Stamatopoulos B; Laboratory of Clinical Cell Therapy, Jules Bordet Institute, ULB Cancer Research Center (U-CRC)- Université Libre de Bruxelles (ULB), Brussels, Belgium., Cabes M; Oxford Molecular Diagnostics Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK., Alsolami R; Department of Medical Laboratory Technology, King Abdulaziz University, Jeddah, Saudi Arabia., Antoniou P; Illumina Cambridge Ltd., Cambridge, UK., Oates M; University of Liverpool, Liverpool, UK., Cavalieri D; Department of Haematology, CHU de Clermont-Ferrand, Clermont-Ferrand, France., Gibson J; Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Prabhu AV; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Schwessinger R; Department of Medicine, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Jennings D; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., James T; Illumina Cambridge Ltd., Cambridge, UK., Maheswari U; Illumina Cambridge Ltd., Cambridge, UK., Duran-Ferrer M; Biomedical Epigenomics Group, Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain., Carninci P; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Human Technopole, Milan, Italy., Knight SJL; Oxford University Clinical Academic Graduate School, University of Oxford Medical Sciences Division, University of Oxford, John Radcliffe Hospital, Oxford, UK., Månsson R; Center for Hematology and Regenerative Medicine Huddinge, Karolinska Institute, Stockholm, Sweden., Hughes J; Department of Medicine, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Davies J; Department of Medicine, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Ross M; Illumina Cambridge Ltd., Cambridge, UK., Bentley D; Illumina Cambridge Ltd., Cambridge, UK., Strefford JC; Cancer Genomics, Cancer Sciences, Faculty of Medicine, Group University of Southampton, Southampton, UK., Devereux S; King's College Hospital, NHS Foundation Trust, London, UK.; Kings College London, London, UK., Pettitt AR; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.; Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK., Hillmen P; St James's University Hospital, Leeds, UK., Caulfield MJ; Genomics England, London, UK.; William Harvey Research Institute, Queen Mary University of London, London, UK., Houlston RS; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK., Martín-Subero JI; Human Technopole, Milan, Italy.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Schuh A; Department of Oncology, University of Oxford, Oxford, UK. anna.schuh@oncology.ox.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2022 Nov; Vol. 54 (11), pp. 1675-1689. Date of Electronic Publication: 2022 Nov 04.

Correction: Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHV ^mut and IgHV ^unmut subgroups.

Autor: Burns A; Department of Molecular Haematology, Oxford Molecular Diagnostics Centre, John Radcliffe Hospital, Oxford, UK.; Department of Oncology, University of Oxford, Oxford, UK., Alsolami R; Department of Molecular Haematology, Oxford Molecular Diagnostics Centre, John Radcliffe Hospital, Oxford, UK.; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.; King Abdulaziz University, Faculty of Applied Medical Sciences, Jeddah, Saudi Arabia., Becq J; Illumina Cambridge Ltd, Saffron Walden, UK., Stamatopoulos B; Department of Molecular Haematology, Oxford Molecular Diagnostics Centre, John Radcliffe Hospital, Oxford, UK., Timbs A; Department of Molecular Haematology, Oxford Molecular Diagnostics Centre, John Radcliffe Hospital, Oxford, UK., Bruce D; Department of Oncology, University of Oxford, Oxford, UK.; Department of Haematology, Oxford University Hospitals NHS Trust, Oxford, UK., Robbe P; Department of Molecular Haematology, Oxford Molecular Diagnostics Centre, John Radcliffe Hospital, Oxford, UK.; Department of Oncology, University of Oxford, Oxford, UK., Vavoulis D; Department of Molecular Haematology, Oxford Molecular Diagnostics Centre, John Radcliffe Hospital, Oxford, UK.; Department of Oncology, University of Oxford, Oxford, UK., Clifford R; Department of Oncology, University of Oxford, Oxford, UK., Cabes M; Department of Molecular Haematology, Oxford Molecular Diagnostics Centre, John Radcliffe Hospital, Oxford, UK., Dreau H; Department of Molecular Haematology, Oxford Molecular Diagnostics Centre, John Radcliffe Hospital, Oxford, UK., Taylor J; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Knight SJL; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Mansson R; Center for Hematology and Regenerative Medicine Huddinge, Karolinska Institute, Stockholm, Sweden., Bentley D; Illumina Cambridge Ltd, Saffron Walden, UK., Beekman R; Biomedical Epigenomics Group, Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain., Martín-Subero JI; Biomedical Epigenomics Group, Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain., Campo E; Hematopathology Unit, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain., Houlston RS; Division of Molecular Pathology, The Institute of Cancer Research, London, UK., Ridout KE; Department of Molecular Haematology, Oxford Molecular Diagnostics Centre, John Radcliffe Hospital, Oxford, UK.; Department of Oncology, University of Oxford, Oxford, UK., Schuh A; Department of Molecular Haematology, Oxford Molecular Diagnostics Centre, John Radcliffe Hospital, Oxford, UK. anna.schuh@oncology.ox.ac.uk.; Department of Oncology, University of Oxford, Oxford, UK. anna.schuh@oncology.ox.ac.uk.; Department of Haematology, Oxford University Hospitals NHS Trust, Oxford, UK. anna.schuh@oncology.ox.ac.uk.

Publikováno v: Leukemia [Leukemia] 2019 Sep; Vol. 33 (9), pp. 2342.

Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHV ^mut and IgHV ^unmut subgroups.

Autor: Burns A, Alsolami R, Becq J, Stamatopoulos B, Timbs A, Bruce D, Robbe P, Vavoulis D, Clifford R, Cabes M, Dreau H, Taylor J, Knight SJL, Mansson R, Bentley D, Beekman R, Martín-Subero JI, Campo E, Houlston RS, Ridout KE, Schuh A

Publikováno v: Leukemia [Leukemia] 2018 Feb; Vol. 32 (2), pp. 573. Date of Electronic Publication: 2017 Nov 21.

Positive selection differs between protein secondary structure elements in Drosophila.

Autor: Ridout KE; Department of Plant Sciences, University of Oxford, Oxford, United Kingdom., Dixon CJ, Filatov DA

Publikováno v: Genome biology and evolution [Genome Biol Evol] 2010 Jul 12; Vol. 2, pp. 166-79. Date of Electronic Publication: 2010 Jul 12.

Realizing precision medicine in chronic lymphocytic leukemia: Remaining challenges and potential opportunities.

Autor: Stamatopoulos, Kostas, Pavlova, Sarka, Al‐Sawaf, Othman, Chatzikonstantinou, Thomas, Karamanidou, Christina, Gaidano, Gianluca, Cymbalista, Florence, Kater, Arnon P., Rawstron, Andy, Scarfò, Lydia, Ghia, Paolo, Rosenquist, Richard

Publikováno v: HemaSphere; Jul2024, Vol. 8 Issue 7, p1-12, 12p